Aliases for SEC61G Gene
External Ids for SEC61G Gene
Previous GeneCards Identifiers for SEC61G Gene
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEC61G Gene
SEC61G (SEC61 Translocon Subunit Gamma) is a Protein Coding gene. Diseases associated with SEC61G include Danubian Endemic Familial Nephropathy and High Grade Ependymoma. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Phagosome. Gene Ontology (GO) annotations related to this gene include protein transporter activity and P-P-bond-hydrolysis-driven protein transmembrane transporter activity.
UniProtKB/Swiss-Prot Summary for SEC61G Gene
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER).