The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein.... See more...

Aliases for SEC61G Gene

Aliases for SEC61G Gene

  • SEC61 Translocon Subunit Gamma 2 3 5
  • Protein Transport Protein Sec61 Subunit Gamma 3 4
  • Sec61 Gamma Subunit 2 3
  • SSS1 2 3
  • Protein Transport Protein SEC61 Gamma Subunit 3
  • SEC61 Translocon Gamma Subunit 3
  • SEC61G 5

External Ids for SEC61G Gene

Previous GeneCards Identifiers for SEC61G Gene

  • GC07M054284
  • GC07M054527
  • GC07M054561
  • GC07M054594
  • GC07M054787
  • GC07M054657

Summaries for SEC61G Gene

Entrez Gene Summary for SEC61G Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC61G Gene

SEC61G (SEC61 Translocon Subunit Gamma) is a Protein Coding gene. Diseases associated with SEC61G include Danubian Endemic Familial Nephropathy and High Grade Ependymoma. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Phagosome. Gene Ontology (GO) annotations related to this gene include protein transporter activity and P-P-bond-hydrolysis-driven protein transmembrane transporter activity.

UniProtKB/Swiss-Prot Summary for SEC61G Gene

  • Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER).

Gene Wiki entry for SEC61G Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEC61G Gene

Genomics for SEC61G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SEC61G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J054757 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 300.2 +1.4 1374 4 TBP SP1 MXD4 CEBPA MNT IKZF1 SMAD5 MBD2 POLR2A ELF1 SEC61G SEC61G-DT L13705-009 lnc-VOPP1-5 HE856050 VSTM2A
GH07J054761 Enhancer 0.2 Ensembl 250.7 -1.7 -1727 0.2 L13705-009 SEC61G SEC61G-DT piR-48373-023 EGFR
GH07J054773 Enhancer 0.8 ENCODE 49.9 -14.3 -14260 1.4 IKZF1 ZNF217 CTCF CEBPB REST MAX ZSCAN9 SMC3 RAD21 RFX5 piR-48373-023 SEC61G SEC61G-DT lnc-SEC61G-8 EGFR
GH07J054809 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 37.3 -51.3 -51349 2.7 CEBPB EP300 JUND ATF2 JUNB BHLHE40 POLR2A RUNX3 SEC61G SEC61G-DT piR-31936-044 piR-50968-120 lnc-SEC61G-1 EGFR
GH07J054704 Enhancer 0.6 Ensembl 45.9 +54.6 54644 1.5 MAFF EP300 RFX5 ZNF316 MAFK IKZF1 CREB1 FOSL2 RFX1 FOS SEC61G HSALNG0058140 ENSG00000288525 VSTM2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC61G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SEC61G

Top Transcription factor binding sites by QIAGEN in the SEC61G gene promoter:
  • c-Myc
  • Egr-2
  • Egr-4
  • Elk-1
  • Evi-1
  • IRF-1
  • Max
  • TBP
  • TFIID
  • XBP-1

Genomic Locations for SEC61G Gene

Latest Assembly
chr7:54,752,250-54,759,974
(GRCh38/hg38)
Size:
7,725 bases
Orientation:
Minus strand

Previous Assembly
chr7:54,819,946-54,826,904
(GRCh37/hg19 by Entrez Gene)
Size:
6,959 bases
Orientation:
Minus strand

chr7:54,819,943-54,827,667
(GRCh37/hg19 by Ensembl)
Size:
7,725 bases
Orientation:
Minus strand

Genomic View for SEC61G Gene

Genes around SEC61G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC61G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC61G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61G Gene

Proteins for SEC61G Gene

  • Protein details for SEC61G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60059-SC61G_HUMAN
    Recommended name:
    Protein transport protein Sec61 subunit gamma
    Protein Accession:
    P60059
    Secondary Accessions:
    • B2R4J0
    • P38384
    • Q6IB25

    Protein attributes for SEC61G Gene

    Size:
    68 amino acids
    Molecular mass:
    7741 Da
    Quaternary structure:
    • The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.
    • (Microbial infection) May interact with Zika virus strain Mr-766 non-structural protein 4A/NS4A (PubMed:30550790). May interact with Zika virus French Polynesia 10087PF/2013 non-structural protein 4A/NS4A (PubMed:30550790).
    • (Microbial infection) May interact with Dengue virus DENV2 16681 non-structural protein 4A/NS4A.

    Three dimensional structures from OCA and Proteopedia for SEC61G Gene

neXtProt entry for SEC61G Gene

Post-translational modifications for SEC61G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC61G Gene

No data available for DME Specific Peptides for SEC61G Gene

Domains & Families for SEC61G Gene

Gene Families for SEC61G Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SEC61G Gene

InterPro:
Blocks:
  • Protein secE/sec61-gamma protein
ProtoNet:

Suggested Antigen Peptide Sequences for SEC61G Gene

GenScript: Design optimal peptide antigens:
  • Protein transport protein Sec61 subunit gamma (SC61G_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P60059

UniProtKB/Swiss-Prot:

SC61G_HUMAN :
  • Belongs to the SecE/SEC61-gamma family.
Family:
  • Belongs to the SecE/SEC61-gamma family.
genes like me logo Genes that share domains with SEC61G: view

Function for SEC61G Gene

Molecular function for SEC61G Gene

UniProtKB/Swiss-Prot Function:
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER).

Phenotypes From GWAS Catalog for SEC61G Gene

Gene Ontology (GO) - Molecular Function for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008320 protein transmembrane transporter activity ISS --
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SEC61G: view
genes like me logo Genes that share phenotypes with SEC61G: view

miRNA for SEC61G Gene

miRTarBase miRNAs that target SEC61G

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC61G

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC61G Gene

Localization for SEC61G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61G Gene

Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC61G gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 22375059
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC61G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEC61G Gene

Pathways & Interactions for SEC61G Gene

genes like me logo Genes that share pathways with SEC61G: view

Pathways by source for SEC61G Gene

3 GeneGo (Thomson Reuters) pathways for SEC61G Gene
  • Immune response Antigen presentation by MHC class I
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR
1 Qiagen pathway for SEC61G Gene
  • Cholera Infection

Gene Ontology (GO) - Biological Process for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0031204 posttranslational protein targeting to membrane, translocation IBA 21873635
GO:0045047 protein targeting to ER ISS --
genes like me logo Genes that share ontologies with SEC61G: view

No data available for SIGNOR curated interactions for SEC61G Gene

Drugs & Compounds for SEC61G Gene

No Compound Related Data Available

Transcripts for SEC61G Gene

mRNA/cDNA for SEC61G Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC61G

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61G Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for SEC61G Gene

GeneLoc Exon Structure for
SEC61G

Expression for SEC61G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEC61G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC61G Gene

This gene is overexpressed in Bone (16.0) and Hair follicle (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEC61G Gene



Protein tissue co-expression partners for SEC61G Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SEC61G

SOURCE GeneReport for Unigene cluster for SEC61G Gene:

Hs.488282

Evidence on tissue expression from TISSUES for SEC61G Gene

  • Nervous system(4.5)
  • Skin(4.5)
  • Blood(4.4)
  • Lung(4.4)
  • Kidney(2.4)
  • Intestine(2.3)
  • Thyroid gland(2.3)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with SEC61G: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC61G Gene

Orthologs for SEC61G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SEC61G 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SEC61G 31
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SEC61G 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SEC61G 30 31
  • 96.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SEC61G 30 31
  • 96.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia LOC102637269 30
  • 92.65 (n)
Sec61g 17 31
  • 68 (a)
OneToOne
Gm11575 17
Gm12881 17
Gm4184 17
Rat
(Rattus norvegicus)
Mammalia LOC499136 30
  • 88.89 (n)
Chicken
(Gallus gallus)
Aves SEC61G 30 31
  • 88.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SEC61G 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sec61g 30
  • 82.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia sec61g-A 30
Zebrafish
(Danio rerio)
Actinopterygii sec61g 30 31
  • 82.35 (n)
OneToOne
hmzehn1231 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10075 30
Fruit Fly
(Drosophila melanogaster)
Insecta Sec61gamma 31
  • 81 (a)
OneToMany
CG8860 30 31
  • 70.15 (n)
OneToMany
CG13426 31
  • 35 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea emo-1 30 31
  • 74.51 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSS1 31
  • 38 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G24920 30
  • 65.69 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0178400 30
  • 59.31 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3850 31
  • 87 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.15317 30
Species where no ortholog for SEC61G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SEC61G Gene

ENSEMBL:
Gene Tree for SEC61G (if available)
TreeFam:
Gene Tree for SEC61G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEC61G: view image

Paralogs for SEC61G Gene

No data available for Paralogs for SEC61G Gene

Variants for SEC61G Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SEC61G Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SEC61G Gene

Variant ID Type Subtype PubMed ID
esv2734425 CNV deletion 23290073
esv2761332 CNV gain 21179565
nsv1024361 CNV gain 25217958
nsv1030676 CNV gain 25217958
nsv607029 CNV gain 21841781

Variation tolerance for SEC61G Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC61G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC61G

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SEC61G Gene

Disorders for SEC61G Gene

MalaCards: The human disease database

(3) MalaCards diseases for SEC61G Gene - From: COP

Disorder Aliases PubMed IDs
danubian endemic familial nephropathy
  • defn
high grade ependymoma
  • ependymal neoplasm
pediatric ependymoma
  • childhood ependymoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SEC61G

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SEC61G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEC61G Gene

Publications for SEC61G Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4
  3. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PMID: 10212142) Greenfield JJ … High S (Journal of cell science 1999) 2 3
  4. Evolutionary conservation of components of the protein translocation complex. (PMID: 8107851) Hartmann E … Rapoport TA (Nature 1994) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for SEC61G Gene

Sources for SEC61G Gene