Aliases for SEC61A1 Gene
External Ids for SEC61A1 Gene
Previous GeneCards Identifiers for SEC61A1 Gene
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEC61A1 Gene
SEC61A1 (SEC61 Translocon Subunit Alpha 1) is a Protein Coding gene. Diseases associated with SEC61A1 include Tubulointerstitial Kidney Disease, Autosomal Dominant, 5 and Primary Agammaglobulinemia. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Phagosome. Gene Ontology (GO) annotations related to this gene include ribosome binding. An important paralog of this gene is SEC61A2.
UniProtKB/Swiss-Prot Summary for SEC61A1 Gene
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).