Aliases for SEC23B Gene
External Ids for SEC23B Gene
Previous HGNC Symbols for SEC23B Gene
Previous GeneCards Identifiers for SEC23B Gene
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]
GeneCards Summary for SEC23B Gene
SEC23B (SEC23 Homolog B, COPII Coat Complex Component) is a Protein Coding gene. Diseases associated with SEC23B include Anemia, Congenital Dyserythropoietic, Type Ii and Cowden Syndrome 7. Among its related pathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Chks in Checkpoint Regulation. An important paralog of this gene is SEC23A.
UniProtKB/Swiss-Prot Summary for SEC23B Gene
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.