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Aliases for SEC22C Gene

Aliases for SEC22C Gene

  • SEC22 Homolog C, Vesicle Trafficking Protein 2 3 5
  • SEC22L3 3 4
  • SEC22 Vesicle Trafficking Protein Homolog C (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like 3 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like Protein C 3
  • SEC22 Vesicle Trafficking Protein Homolog C 3
  • SEC22 Vesicle-Trafficking Protein Homolog C 4
  • SEC22 Vesicle Trafficking Protein-Like 3 3
  • SEC22 Vesicle-Trafficking Protein-Like 3 4
  • Vesicle-Trafficking Protein SEC22c 3
  • Secretion Deficient 22C 3

External Ids for SEC22C Gene

Previous HGNC Symbols for SEC22C Gene

  • SEC22L3

Previous GeneCards Identifiers for SEC22C Gene

  • GC03M041894
  • GC03M042565

Summaries for SEC22C Gene

Entrez Gene Summary for SEC22C Gene

  • This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for SEC22C Gene

SEC22C (SEC22 Homolog C, Vesicle Trafficking Protein) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is SEC22A.

UniProtKB/Swiss-Prot for SEC22C Gene

  • May be involved in vesicle transport between the ER and the Golgi complex.

Additional gene information for SEC22C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22C Gene

Genomics for SEC22C Gene

GeneHancer (GH) Regulatory Elements for SEC22C Gene

Promoters and enhancers for SEC22C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I042599 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 591.8 -0.1 -55 3.8 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 NKTR SEC22C SNRK-AS1 LOC101928323 ZBTB47
GH03I042580 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 576.9 +19.0 18988 2.7 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SEC22C SS18L2 NKTR SNRK-AS1 ENSG00000271941
GH03I042594 Promoter 0.5 EPDnew 550.4 +6.2 6193 0.1 SEC22C CCDC13-AS1 CCDC13 NKTR SS18L2
GH03I042650 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 40.2 -52.7 -52748 6.4 HDGF PKNOX1 ARNT ZFP64 SIN3A DMAP1 POLR2B CBX5 FOS SP3 ZBTB47 LOC101928323 NKTR SEC22C SNRK-AS1 SS18L2 HHATL FAM198A
GH03I042589 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 41.5 +10.1 10114 2.5 HDGF PKNOX1 ATF1 IRF4 BRCA1 YY1 GTF3C2 POLR2B GLIS2 ZNF207 SS18L2 SEC22C NKTR CCDC13-AS1 CCDC13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEC22C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC22C gene promoter:

Genomic Locations for SEC22C Gene

Genomic Locations for SEC22C Gene
53,114 bases
Minus strand

Genomic View for SEC22C Gene

Genes around SEC22C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22C Gene

Proteins for SEC22C Gene

  • Protein details for SEC22C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle-trafficking protein SEC22c
    Protein Accession:
    Secondary Accessions:
    • O95152
    • Q68CX3
    • Q6UW18

    Protein attributes for SEC22C Gene

    303 amino acids
    Molecular mass:
    34269 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SEC22C Gene


neXtProt entry for SEC22C Gene

Post-translational modifications for SEC22C Gene

  • Ubiquitination at isoforms=297
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEC22C Gene

Domains & Families for SEC22C Gene

Gene Families for SEC22C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for SEC22C Gene

Suggested Antigen Peptide Sequences for SEC22C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptobrevin family.
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22C: view

Function for SEC22C Gene

Molecular function for SEC22C Gene

UniProtKB/Swiss-Prot Function:
May be involved in vesicle transport between the ER and the Golgi complex.

Phenotypes From GWAS Catalog for SEC22C Gene

Gene Ontology (GO) - Molecular Function for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SEC22C: view
genes like me logo Genes that share phenotypes with SEC22C: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC22C Gene

Localization for SEC22C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC22C gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9501016
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with SEC22C: view

Pathways & Interactions for SEC22C Gene

genes like me logo Genes that share pathways with SEC22C: view

Gene Ontology (GO) - Biological Process for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 NOT exocytosis IBA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS 9501016
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with SEC22C: view

No data available for SIGNOR curated interactions for SEC22C Gene

Drugs & Compounds for SEC22C Gene

No Compound Related Data Available

Transcripts for SEC22C Gene

Unigene Clusters for SEC22C Gene

SEC22 vesicle trafficking protein homolog C (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - - -

ExUns: 13 ^ 14 ^ 15
SP1: -
SP5: - -

Relevant External Links for SEC22C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC22C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC22C Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC22C Gene:


SOURCE GeneReport for Unigene cluster for SEC22C Gene:


mRNA Expression by UniProt/SwissProt for SEC22C Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SEC22C Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with SEC22C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC22C Gene

Orthologs for SEC22C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC22C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC22C 33 34
  • 99.56 (n)
(Canis familiaris)
Mammalia SEC22C 33 34
  • 91.2 (n)
(Bos Taurus)
Mammalia SEC22C 33 34
  • 90.32 (n)
(Mus musculus)
Mammalia Sec22c 33 16 34
  • 83.83 (n)
(Rattus norvegicus)
Mammalia LOC687022 33
  • 74.64 (n)
(Monodelphis domestica)
Mammalia SEC22C 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia SEC22C 34
  • 65 (a)
(Gallus gallus)
Aves SEC22C 33 34
  • 71.18 (n)
(Anolis carolinensis)
Reptilia SEC22C 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22c 33
  • 61.36 (n)
(Danio rerio)
Actinopterygii sec22c 33 34
  • 59.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sec22 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea sec-22 34
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for SEC22C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22C Gene

Gene Tree for SEC22C (if available)
Gene Tree for SEC22C (if available)

Paralogs for SEC22C Gene

Paralogs for SEC22C Gene

(1) SIMAP similar genes for SEC22C Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SEC22C: view

Variants for SEC22C Gene

Sequence variations from dbSNP and Humsavar for SEC22C Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000031355 -- 42,587,536(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000047793 -- 42,594,248(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000079707 -- 42,570,638(-) G/A intron_variant
rs1000115352 -- 42,589,997(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000183047 -- 42,591,523(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC22C Gene

Variant ID Type Subtype PubMed ID
esv2678489 CNV deletion 23128226
esv3596001 CNV loss 21293372
esv3596002 CNV loss 21293372

Variation tolerance for SEC22C Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC22C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC22C Gene

Disorders for SEC22C Gene

Additional Disease Information for SEC22C

No disorders were found for SEC22C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC22C Gene

Publications for SEC22C Gene

  1. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PMID: 9501016) Tang BL … Hong W (Biochemical and biophysical research communications 1998) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The number of the C-terminal transmembrane domains has the potency to specify subcellular localization of Sec22c. (PMID: 28414125) Yamamoto Y … Sakisaka T (Biochemical and biophysical research communications 2017) 3 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for SEC22C Gene

Sources for SEC22C Gene

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