The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009] See more...

Aliases for SEC22B Gene

Aliases for SEC22B Gene

  • SEC22 Homolog B, Vesicle Trafficking Protein 2 3
  • ERS-24 2 3 4
  • SEC22 Homolog B, Vesicle Trafficking Protein (Gene/Pseudogene) 2 5
  • Vesicle-Trafficking Protein SEC22b 3 4
  • ER-Golgi SNARE Of 24 KDa 3 4
  • SEC22L1 3 4
  • SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) (Gene/Pseudogene) 2
  • SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) 2
  • SEC22, Vesicle Trafficking Protein (S. Cerevisiae)-Like 1 2
  • SEC22 Vesicle Trafficking Protein-Like 1 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein Homolog B 3
  • SEC22 Vesicle-Trafficking Protein Homolog B 4
  • SEC22 Vesicle Trafficking Protein-Like 1 3
  • SEC22 Vesicle-Trafficking Protein-Like 1 4
  • SEC22B 5
  • ERS24 4

External Ids for SEC22B Gene

Previous HGNC Symbols for SEC22B Gene

  • SEC22L1

Previous GeneCards Identifiers for SEC22B Gene

  • GC01P143807
  • GC01P145096

Summaries for SEC22B Gene

Entrez Gene Summary for SEC22B Gene

  • The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]

GeneCards Summary for SEC22B Gene

SEC22B (SEC22 Homolog B, Vesicle Trafficking Protein) is a Protein Coding gene. Diseases associated with SEC22B include Legionellosis and Legionnaire Disease. Among its related pathways are Antigen processing-Cross presentation and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include syntaxin binding. An important paralog of this gene is SEC22A.

UniProtKB/Swiss-Prot Summary for SEC22B Gene

  • SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Gene Wiki entry for SEC22B Gene

Additional gene information for SEC22B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEC22B Gene

Genomics for SEC22B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SEC22B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J120174 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 607.7 +0.9 919 3.2 SP1 HNRNPL GATAD2A TEAD4 PRDM10 REST ZNF629 SIX5 LEF1 IKZF1 SEC22B HSALNG0006534-001 NOTCH2
GH01J120340 Promoter 1.4 EPDnew Ensembl 600.1 -165.0 -164981 4.6 RNF2 TEAD4 PRDM10 ZNF629 RFX1 IKZF1 BACH1 LARP7 PRDM1 ZNF143 ENSG00000223804 LOC105378954 lnc-SEC22B-2 SEC22B LOC107985522 NBPF8
GH01J120149 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 0.4 +21.3 21320 12 POLR2A SUPT5H POLR2B HSALNG0006534-001 NOTCH2 NBPF7 NONHSAG002603.2 SEC22B
GH01J120141 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 0.3 +32.7 32680 3 IKZF2 ARID3A DPF2 RELB ARNT IKZF1 TBX21 MTA2 BHLHE40 MLLT1 ZNF697 NOTCH2 NONHSAG002603.2 RF00026-065 SEC22B
GH01J120131 Promoter/Enhancer 0.6 Ensembl dbSUPER 0.3 +44.4 44419 0.2 EMSY RF00026-065 LOC105378940 NONHSAG002603.2 NOTCH2 SEC22B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC22B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SEC22B

Top Transcription factor binding sites by QIAGEN in the SEC22B gene promoter:
  • aMEF-2
  • ATF6
  • Cart-1
  • Ik-2
  • MEF-2A
  • Pax-6
  • POU2F1
  • POU2F1a
  • TBP
  • ZID

Genomic Locations for SEC22B Gene

Genomic Locations for SEC22B Gene
chr1:120,150,898-120,176,520
(GRCh38/hg38)
Size:
25,623 bases
Orientation:
Minus strand
chr1:145,096,220-145,116,922
(GRCh37/hg19)
Size:
20,703 bases
Orientation:
Plus strand

Genomic View for SEC22B Gene

Genes around SEC22B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22B Gene

Proteins for SEC22B Gene

  • Protein details for SEC22B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75396-SC22B_HUMAN
    Recommended name:
    Vesicle-trafficking protein SEC22b
    Protein Accession:
    O75396
    Secondary Accessions:
    • A8K1G0

    Protein attributes for SEC22B Gene

    Size:
    215 amino acids
    Molecular mass:
    24593 Da
    Quaternary structure:
    • Interacts with STX17 (By similarity). Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex. Interacts with the COPII Sec23/24 complex composed of SEC23A and SEC24A; recruits SEC22B into COPII-coated vesicles to allow its transport from the endoplasmic reticulum to the Golgi (PubMed:17499046, PubMed:18843296).
    SequenceCaution:
    • Sequence=AL359758; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC22B Gene

neXtProt entry for SEC22B Gene

Post-translational modifications for SEC22B Gene

  • Ubiquitination at Lys38 and Lys169
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SC22B_HUMAN (1891)

Other Protein References for SEC22B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEC22B Gene

Domains & Families for SEC22B Gene

Gene Families for SEC22B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SEC22B Gene

InterPro:
Blocks:
  • Synaptobrevin
ProtoNet:

Suggested Antigen Peptide Sequences for SEC22B Gene

GenScript: Design optimal peptide antigens:
  • SEC22 vesicle-trafficking protein-like 1 (SC22B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75396

UniProtKB/Swiss-Prot:

SC22B_HUMAN :
  • Belongs to the synaptobrevin family.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22B: view

Function for SEC22B Gene

Molecular function for SEC22B Gene

UniProtKB/Swiss-Prot Function:
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Phenotypes From GWAS Catalog for SEC22B Gene

Gene Ontology (GO) - Molecular Function for SEC22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA 21873635
GO:0005515 protein binding IPI 15272311
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with SEC22B: view
genes like me logo Genes that share phenotypes with SEC22B: view

Animal Models for SEC22B Gene

MGI Knock Outs for SEC22B:
  • Sec22b Sec22b<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC22B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SEC22B Gene

Localization for SEC22B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22B Gene

Endoplasmic reticulum membrane. Single-pass type IV membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250 UniProtKB:Q4KM74, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC22B gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 2
endosome 2
cytosol 2
lysosome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SEC22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA,TAS --
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with SEC22B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEC22B Gene

Pathways & Interactions for SEC22B Gene

genes like me logo Genes that share pathways with SEC22B: view

Pathways by source for SEC22B Gene

Gene Ontology (GO) - Biological Process for SEC22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA,TAS --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with SEC22B: view

No data available for SIGNOR curated interactions for SEC22B Gene

Drugs & Compounds for SEC22B Gene

No Compound Related Data Available

Transcripts for SEC22B Gene

mRNA/cDNA for SEC22B Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC22B

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22B Gene

No ASD Table

Relevant External Links for SEC22B Gene

GeneLoc Exon Structure for
SEC22B

Expression for SEC22B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEC22B Gene

Protein differential expression in normal tissues from HIPED for SEC22B Gene

This gene is overexpressed in Bone (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEC22B Gene



Protein tissue co-expression partners for SEC22B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SEC22B

SOURCE GeneReport for Unigene cluster for SEC22B Gene:

Hs.632438

Evidence on tissue expression from TISSUES for SEC22B Gene

  • Blood(4.3)
  • Liver(4.3)
  • Nervous system(4.3)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with SEC22B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC22B Gene

Orthologs for SEC22B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC22B Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia LOC475816 30
  • 94.42 (n)
Cow
(Bos Taurus)
Mammalia LOC614775 30
  • 93.05 (n)
Mouse
(Mus musculus)
Mammalia Sec22b 30 17
  • 93.02 (n)
Rat
(Rattus norvegicus)
Mammalia Sec22b 30
  • 91.63 (n)
Chicken
(Gallus gallus)
Aves SEC22B 30
  • 83.26 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sec22b 30
  • 80 (n)
Sec22l1-prov 30
Zebrafish
(Danio rerio)
Actinopterygii sec22bb 30
  • 76.59 (n)
sec22l1b 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9851 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012717 30
  • 60.61 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Sec22 30
  • 57.66 (n)
Worm
(Caenorhabditis elegans)
Secernentea sec-22 30
  • 52.07 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR267W 30
  • 51.46 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 30
  • 51.05 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20251g 30
  • 48.31 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons SEC22 30
  • 54.11 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0791500 30
  • 53.23 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec22 30
  • 48.8 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU06708 30
  • 46.93 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.12748 30
Species where no ortholog for SEC22B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SEC22B Gene

ENSEMBL:
Gene Tree for SEC22B (if available)
TreeFam:
Gene Tree for SEC22B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEC22B: view image

Paralogs for SEC22B Gene

(1) SIMAP similar genes for SEC22B Gene using alignment to 6 proteins:

  • SC22B_HUMAN
  • I1VE16_HUMAN
  • I1VE17_HUMAN
  • I1VE18_HUMAN
  • I1VE19_HUMAN
  • I1VE20_HUMAN

Pseudogenes.org Pseudogenes for SEC22B Gene

genes like me logo Genes that share paralogs with SEC22B: view

Variants for SEC22B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SEC22B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2590131 - p.Cys130Arg
rs2596331 - p.Asp71Tyr
rs2655551 - p.Arg108Gln
rs2655557 - p.His190Arg
rs2794053 - p.Thr82Lys

Additional dbSNP identifiers (rs#s) for SEC22B Gene

Structural Variations from Database of Genomic Variants (DGV) for SEC22B Gene

Variant ID Type Subtype PubMed ID
dgv178n106 CNV deletion 24896259
dgv7e180 CNV deletion 20482838
esv2229660 CNV deletion 18987734
esv2548575 CNV deletion 19546169
esv2849791 CNV deletion 24192839
esv3540345 CNV deletion 23714750
esv5594 CNV loss 19470904
nsv1078169 CNV deletion 25765185
nsv161167 CNV deletion 16902084
nsv511713 CNV loss 21212237
nsv524681 CNV gain 19592680
nsv957355 CNV deletion 24416366

Additional Variant Information for SEC22B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC22B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SEC22B Gene

Disorders for SEC22B Gene

MalaCards: The human disease database

(8) MalaCards diseases for SEC22B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
legionellosis
  • pontiac fever
legionnaire disease
  • legionnaire disease, susceptibility to
adult pineal parenchymal tumor
  • adult pineal parenchymal neoplasm
adult pineoblastoma
pontiac fever
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SEC22B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEC22B Gene

Publications for SEC22B Gene

  1. The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope. (PMID: 17499046) Mancias JD … Goldberg J (Molecular cell 2007) 3 4
  2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4
  3. Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. (PMID: 16354670) Okumura AJ … Wada I (The Journal of biological chemistry 2006) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SEC22B Gene

  • Signalway Proteins for SEC22B

Sources for SEC22B Gene