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Aliases for SEC22B Gene

Aliases for SEC22B Gene

  • SEC22 Homolog B, Vesicle Trafficking Protein (Gene/Pseudogene) 2 3 5
  • ER-Golgi SNARE Of 24 KDa 3 4
  • SEC22L1 3 4
  • ERS-24 3 4
  • SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) (Gene/Pseudogene) 2
  • SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) 2
  • SEC22, Vesicle Trafficking Protein (S. Cerevisiae)-Like 1 2
  • SEC22 Vesicle Trafficking Protein-Like 1 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein Homolog B 3
  • SEC22 Vesicle-Trafficking Protein Homolog B 4
  • SEC22 Vesicle Trafficking Protein-Like 1 3
  • SEC22 Vesicle-Trafficking Protein-Like 1 4
  • Vesicle-Trafficking Protein SEC22b 3
  • ERS24 4

External Ids for SEC22B Gene

Previous HGNC Symbols for SEC22B Gene

  • SEC22L1

Previous GeneCards Identifiers for SEC22B Gene

  • GC01P143807
  • GC01P145096

Summaries for SEC22B Gene

Entrez Gene Summary for SEC22B Gene

  • The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]

GeneCards Summary for SEC22B Gene

SEC22B (SEC22 Homolog B, Vesicle Trafficking Protein (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include syntaxin binding. An important paralog of this gene is SEC22A.

UniProtKB/Swiss-Prot for SEC22B Gene

  • SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Gene Wiki entry for SEC22B Gene

Additional gene information for SEC22B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22B Gene

Genomics for SEC22B Gene

GeneHancer (GH) Regulatory Elements for SEC22B Gene

Promoters and enhancers for SEC22B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I120175 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.6 587 2.3 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 SEC22B GC01P120130
GH01I120178 Enhancer 0.7 Ensembl 7.4 -3.6 -3580 2.6 SP3 ZBTB6 TEAD4 ZSCAN4 DPF2 YY1 JUND PRDM10 CUX1 ZNF600 SEC22B LOC100996723
GH01I120141 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +32.8 32820 3.8 IKZF1 MLLT1 DPF2 IKZF2 SPI1 ZNF507 ZNF697 NOTCH2 GC01P120130 SEC22B
GH01I120136 Enhancer 0.6 Ensembl dbSUPER 0.3 +39.8 39821 0.6 RNF2 SCRT2 BMI1 GC01P120130 LOC105378940 SEC22B
GH01I120131 Enhancer 0.6 Ensembl dbSUPER 0.3 +44.5 44520 1.6 ZNF316 MAFG EMSY GC01P120130 LOC105378940 SEC22B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEC22B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC22B gene promoter:

Genomic Locations for SEC22B Gene

Genomic Locations for SEC22B Gene
25,624 bases
Minus strand

Genomic View for SEC22B Gene

Genes around SEC22B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22B Gene

Proteins for SEC22B Gene

  • Protein details for SEC22B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle-trafficking protein SEC22b
    Protein Accession:
    Secondary Accessions:
    • A8K1G0

    Protein attributes for SEC22B Gene

    215 amino acids
    Molecular mass:
    24593 Da
    Quaternary structure:
    • Interacts with STX17 (By similarity). Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex. Interacts with the COPII Sec23/24 complex composed of SEC23A and SEC24A; recruits SEC22B into COPII-coated vesicles to allow its transport from the endoplasmic reticulum to the Golgi (PubMed:17499046, PubMed:18843296).
    • Sequence=AL359758; Type=Erroneous termination; Positions=39; Note=Translated as Gln.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC22B Gene

neXtProt entry for SEC22B Gene

Post-translational modifications for SEC22B Gene

Other Protein References for SEC22B Gene

No data available for DME Specific Peptides for SEC22B Gene

Domains & Families for SEC22B Gene

Gene Families for SEC22B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SEC22B Gene

Suggested Antigen Peptide Sequences for SEC22B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptobrevin family.
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22B: view

Function for SEC22B Gene

Molecular function for SEC22B Gene

UniProtKB/Swiss-Prot Function:
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Gene Ontology (GO) - Molecular Function for SEC22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 15272311
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with SEC22B: view

Phenotypes for SEC22B Gene

genes like me logo Genes that share phenotypes with SEC22B: view

Animal Models for SEC22B Gene

MGI Knock Outs for SEC22B:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SEC22B Gene

Localization for SEC22B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22B Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250 UniProtKB:Q4KM74, ECO:0000269 PubMed:17081065}.

Gene Ontology (GO) - Cellular Components for SEC22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with SEC22B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SEC22B Gene

Pathways & Interactions for SEC22B Gene

genes like me logo Genes that share pathways with SEC22B: view

Gene Ontology (GO) - Biological Process for SEC22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006810 transport IEA --
GO:0006887 NOT exocytosis IBA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
genes like me logo Genes that share ontologies with SEC22B: view

No data available for SIGNOR curated interactions for SEC22B Gene

Drugs & Compounds for SEC22B Gene

No Compound Related Data Available

Transcripts for SEC22B Gene

mRNA/cDNA for SEC22B Gene

Unigene Clusters for SEC22B Gene

SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22B Gene

No ASD Table

Relevant External Links for SEC22B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC22B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC22B Gene

Protein differential expression in normal tissues from HIPED for SEC22B Gene

This gene is overexpressed in Bone (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEC22B Gene

Protein tissue co-expression partners for SEC22B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC22B Gene:


SOURCE GeneReport for Unigene cluster for SEC22B Gene:

genes like me logo Genes that share expression patterns with SEC22B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC22B Gene

Orthologs for SEC22B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC22B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC475816 33
  • 94.42 (n)
(Bos Taurus)
Mammalia LOC614775 33
  • 93.05 (n)
(Mus musculus)
Mammalia Sec22b 33 16
  • 93.02 (n)
(Rattus norvegicus)
Mammalia Sec22b 33
  • 91.63 (n)
(Gallus gallus)
Aves SEC22B 33
  • 83.26 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22b 33
  • 80 (n)
Sec22l1-prov 33
(Danio rerio)
Actinopterygii LOC100535340 33
  • 76.59 (n)
sec22l1b 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9851 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012717 33
  • 60.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sec22 33
  • 57.66 (n)
(Caenorhabditis elegans)
Secernentea sec-22 33
  • 52.07 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR267W 33
  • 51.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 33
  • 51.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20251g 33
  • 48.31 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC22 33
  • 54.11 (n)
(Oryza sativa)
Liliopsida Os03g0791500 33
  • 53.23 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec22 33
  • 48.8 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06708 33
  • 46.93 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12748 33
Species where no ortholog for SEC22B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22B Gene

Gene Tree for SEC22B (if available)
Gene Tree for SEC22B (if available)

Paralogs for SEC22B Gene

Paralogs for SEC22B Gene

(1) SIMAP similar genes for SEC22B Gene using alignment to 6 proteins: Pseudogenes for SEC22B Gene

genes like me logo Genes that share paralogs with SEC22B: view

Variants for SEC22B Gene

Sequence variations from dbSNP and Humsavar for SEC22B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1048141 -- 120,156,120(-) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1048143 -- 120,156,112(-) G/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs10797289 -- 120,153,694(-) G/A/C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs111256146 -- 120,178,255(-) C/A upstream_transcript_variant
rs111388320 -- 120,178,175(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC22B Gene

Variant ID Type Subtype PubMed ID
nsv957355 CNV deletion 24416366
nsv524681 CNV gain 19592680
nsv511713 CNV loss 21212237
nsv161167 CNV deletion 16902084
nsv1078169 CNV deletion 25765185
esv5594 CNV loss 19470904
esv3540345 CNV deletion 23714750
esv2849791 CNV deletion 24192839
esv2548575 CNV deletion 19546169
esv2229660 CNV deletion 18987734
dgv7e180 CNV deletion 20482838
dgv178n106 CNV deletion 24896259

Additional Variant Information for SEC22B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SEC22B Gene

Disorders for SEC22B Gene

Additional Disease Information for SEC22B

No disorders were found for SEC22B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC22B Gene

Publications for SEC22B Gene

  1. The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope. (PMID: 17499046) Mancias JD … Goldberg J (Molecular cell 2007) 3 4 58
  2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4 58
  3. Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. (PMID: 16354670) Okumura AJ … Wada I (The Journal of biological chemistry 2006) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SEC22B Gene

Sources for SEC22B Gene

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