The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008] See more...

Aliases for SEC22A Gene

Aliases for SEC22A Gene

  • SEC22 Homolog A, Vesicle Trafficking Protein 2 3 5
  • Vesicle-Trafficking Protein SEC22a 3 4
  • SEC22L2 3 4
  • SEC22 Vesicle Trafficking Protein Homolog A (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like 2 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein Homolog A 3
  • SEC22 Vesicle-Trafficking Protein Homolog A 4
  • SEC22 Vesicle Trafficking Protein-Like 2 3
  • SEC22 Vesicle-Trafficking Protein-Like 2 4

External Ids for SEC22A Gene

Previous HGNC Symbols for SEC22A Gene

  • SEC22L2

Previous GeneCards Identifiers for SEC22A Gene

  • GC03P119643
  • GC03P124404
  • GC03P122920
  • GC03P120295

Summaries for SEC22A Gene

Entrez Gene Summary for SEC22A Gene

  • The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]

GeneCards Summary for SEC22A Gene

SEC22A (SEC22 Homolog A, Vesicle Trafficking Protein) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include transporter activity and SNAP receptor activity. An important paralog of this gene is SEC22C.

UniProtKB/Swiss-Prot Summary for SEC22A Gene

  • May be involved in vesicle transport between the ER and the Golgi complex.

Gene Wiki entry for SEC22A Gene

Additional gene information for SEC22A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEC22A Gene

Genomics for SEC22A Gene

GeneHancer (GH) Regulatory Elements for SEC22A Gene

Promoters and enhancers for SEC22A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J123200 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 530.6 +0.1 128 2.3 ZNF217 EP300 SIN3A TCF12 NRF1 POLR2G SP1 PHF8 POLR2A CLOCK SEC22A HSALNG0028522 ENSG00000273454 PDIA5
GH03J123272 Enhancer 0.8 Ensembl ENCODE 40.7 +71.5 71474 2 ZNF300 JUND NFIC FOS NFE2 MAFK POLR2A NFIB JUN NFIA SEC22A ENSG00000273454 HSALNG0028522
GH03J122645 Enhancer 0.8 ENCODE 33.6 -555.2 -555209 1.5 ZNF354C ZNF623 ZNF510 ZNF266 IRF1 MEF2B NBN ZBTB11 ZNF426 ZNF213 IQCB1 GOLGB1 SEC22A ENSG00000272758 ENSG00000273454 PARP14 EIF4BP8 piR-48128
GH03J124032 Promoter/Enhancer 1.7 EPDnew ENCODE CraniofacialAtlas 14 +831.1 831127 2.6 EP300 CTCF ZFX ZIC2 ZBTB10 GABPA ZBTB26 SAP30 ZEB1 MXI1 KALRN HSALNG0028564 lnc-KALRN-3 SEC22A ROPN1 UMPS
GH03J122938 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14 -261.0 -261027 6.2 CTCF ZIC2 GABPA REST RAD21 MYC TRIM22 SMC3 MXI1 RBM25 SEC22A ENSG00000272758 SEMA5B HSPBAP1 piR-61945-360 lnc-PDIA5-1 lnc-HSPBAP1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC22A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SEC22A

Top Transcription factor binding sites by QIAGEN in the SEC22A gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • LCR-F1
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • TBP
  • TFIID

Genomic Locations for SEC22A Gene

Genomic Locations for SEC22A Gene
chr3:123,201,927-123,274,136
(GRCh38/hg38)
Size:
72,210 bases
Orientation:
Plus strand
chr3:122,920,774-122,992,983
(GRCh37/hg19)
Size:
72,210 bases
Orientation:
Plus strand

Genomic View for SEC22A Gene

Genes around SEC22A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22A Gene

Proteins for SEC22A Gene

  • Protein details for SEC22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IW7-SC22A_HUMAN
    Recommended name:
    Vesicle-trafficking protein SEC22a
    Protein Accession:
    Q96IW7
    Secondary Accessions:
    • B2RE26
    • Q9Y682

    Protein attributes for SEC22A Gene

    Size:
    307 amino acids
    Molecular mass:
    34948 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD43013.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for SEC22A Gene

Post-translational modifications for SEC22A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEC22A Gene

Domains & Families for SEC22A Gene

Gene Families for SEC22A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SEC22A Gene

Blocks:
  • Synaptobrevin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SEC22A Gene

GenScript: Design optimal peptide antigens:
  • SEC22 vesicle-trafficking protein-like 2 (SC22A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96IW7

UniProtKB/Swiss-Prot:

SC22A_HUMAN :
  • Belongs to the synaptobrevin family.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22A: view

Function for SEC22A Gene

Molecular function for SEC22A Gene

UniProtKB/Swiss-Prot Function:
May be involved in vesicle transport between the ER and the Golgi complex.

Phenotypes From GWAS Catalog for SEC22A Gene

Gene Ontology (GO) - Molecular Function for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 8621431
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with SEC22A: view
genes like me logo Genes that share phenotypes with SEC22A: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC22A Gene

Localization for SEC22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC22A gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC22A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEC22A Gene

Pathways & Interactions for SEC22A Gene

genes like me logo Genes that share pathways with SEC22A: view

Gene Ontology (GO) - Biological Process for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with SEC22A: view

No data available for SIGNOR curated interactions for SEC22A Gene

Drugs & Compounds for SEC22A Gene

No Compound Related Data Available

Transcripts for SEC22A Gene

mRNA/cDNA for SEC22A Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - -
SP7:
SP8: - -
SP9: -
SP10: -

Relevant External Links for SEC22A Gene

GeneLoc Exon Structure for
SEC22A

Expression for SEC22A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEC22A Gene

Protein differential expression in normal tissues from HIPED for SEC22A Gene

This gene is overexpressed in Islet of Langerhans (21.1) and Testis (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEC22A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SEC22A

SOURCE GeneReport for Unigene cluster for SEC22A Gene:

Hs.477361

Evidence on tissue expression from TISSUES for SEC22A Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with SEC22A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC22A Gene

Orthologs for SEC22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC22A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC22A 31 30
  • 99.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SEC22A 31 30
  • 95.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SEC22A 31 30
  • 95.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sec22a 17 31 30
  • 93.38 (n)
rat
(Rattus norvegicus)
Mammalia Sec22a 30
  • 92.73 (n)
oppossum
(Monodelphis domestica)
Mammalia SEC22A 31
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC22A 31
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC22A 31 30
  • 81.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC22A 31
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22l2 30
  • 66.45 (n)
Str.10293 30
zebrafish
(Danio rerio)
Actinopterygii sec22a 31 30
  • 68.21 (n)
OneToOne
-- 30
fruit fly
(Drosophila melanogaster)
Insecta Sec22 31
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-22 31
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 33 31
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 31 (a)
OneToMany
Species where no ortholog for SEC22A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22A Gene

ENSEMBL:
Gene Tree for SEC22A (if available)
TreeFam:
Gene Tree for SEC22A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEC22A: view image

Paralogs for SEC22A Gene

(2) SIMAP similar genes for SEC22A Gene using alignment to 8 proteins:

  • SC22A_HUMAN
  • C9J463_HUMAN
  • C9JDJ8_HUMAN
  • C9JNZ0_HUMAN
  • C9JR77_HUMAN
  • C9JRY4_HUMAN
  • C9JZ27_HUMAN
  • F8WAU7_HUMAN
genes like me logo Genes that share paralogs with SEC22A: view

Variants for SEC22A Gene

Additional dbSNP identifiers (rs#s) for SEC22A Gene

Structural Variations from Database of Genomic Variants (DGV) for SEC22A Gene

Variant ID Type Subtype PubMed ID
dgv297n21 CNV loss 19592680
esv275521 CNV gain+loss 21479260
nsv1003681 CNV gain 25217958
nsv1013747 CNV loss 25217958
nsv1127990 CNV deletion 24896259
nsv3976 CNV insertion 18451855
nsv524614 CNV loss 19592680

Variation tolerance for SEC22A Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC22A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC22A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SEC22A Gene

Disorders for SEC22A Gene

Additional Disease Information for SEC22A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SEC22A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC22A Gene

Publications for SEC22A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 54
  5. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PMID: 9501016) Tang BL … Hong W (Biochemical and biophysical research communications 1998) 2 3 54

Products for SEC22A Gene

Sources for SEC22A Gene