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The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]
SEC22A (SEC22 Homolog A, Vesicle Trafficking Protein) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include transporter activity and SNAP receptor activity. An important paralog of this gene is SEC22C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005215 | transporter activity | TAS | 8621431 |
GO:0005515 | protein binding | IPI | 21516116 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS,IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport to the Golgi and subsequent modification | ||
2 | Vesicle-mediated transport | ||
3 | Metabolism of proteins | ||
4 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006888 | ER to Golgi vesicle-mediated transport | IEA | -- |
GO:0015031 | protein transport | IEA | -- |
GO:0016192 | vesicle-mediated transport | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP10: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SEC22A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SEC22A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SEC22A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Sec22a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sec22a 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SEC22A 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SEC22A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SEC22A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SEC22A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sec22l2 30 |
|
||
Str.10293 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | sec22a 30 31 |
|
OneToOne | |
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Sec22 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | sec-22 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC22 31 33 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv297n21 | CNV | loss | 19592680 |
esv275521 | CNV | gain+loss | 21479260 |
nsv1003681 | CNV | gain | 25217958 |
nsv1013747 | CNV | loss | 25217958 |
nsv1127990 | CNV | deletion | 24896259 |
nsv3976 | CNV | insertion | 18451855 |
nsv524614 | CNV | loss | 19592680 |
No disorders were found for SEC22A Gene.