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Aliases for SEC16B Gene

Aliases for SEC16B Gene

  • SEC16 Homolog B, Endoplasmic Reticulum Export Factor 2 3 5
  • Leucine Zipper Transcription Regulator 2 2 3 4
  • Regucalcin Gene Promoter Region-Related Protein P117 3 4
  • Regucalcin Gene Promotor Region Related Protein 2 3
  • RGPR-P117 3 4
  • SEC16S 3 4
  • LZTR2 3 4
  • RGPR 3 4
  • Protein Transport Protein Sec16B 3
  • SEC16 Homolog B (S. Cerevisiae) 2
  • Protein SEC16 Homolog B 3
  • SEC16 Homolog B 4
  • PGPR-P117 3
  • KIAA1928 4

External Ids for SEC16B Gene

Previous HGNC Symbols for SEC16B Gene

  • LZTR2

Previous GeneCards Identifiers for SEC16B Gene

  • GC01M176166
  • GC01M177896
  • GC01M149125

Summaries for SEC16B Gene

Entrez Gene Summary for SEC16B Gene

  • SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SEC16B Gene

SEC16B (SEC16 Homolog B, Endoplasmic Reticulum Export Factor) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. An important paralog of this gene is SEC16A.

UniProtKB/Swiss-Prot for SEC16B Gene

  • Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization.

Gene Wiki entry for SEC16B Gene

Additional gene information for SEC16B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC16B Gene

Genomics for SEC16B Gene

GeneHancer (GH) Regulatory Elements for SEC16B Gene

Promoters and enhancers for SEC16B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I177968 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 564 +14.6 14623 3.1 ELF3 FOXA2 DMAP1 ZNF48 RAD21 YY1 RXRA ZHX2 ELF1 REST SEC16B CRYZL2P GC01M177906 CRYZL2P-SEC16B
GH01I177983 Enhancer 1 Ensembl ENCODE 550.8 +0.3 265 1.8 ATF1 ARNT ZNF76 SIN3A ZBTB40 YY1 ETS1 ZNF335 ZSCAN5C ZNF350 SEC16B CRYZL2P-SEC16B GC01M177906
GH01I178055 Enhancer 1.1 Ensembl ENCODE 11.8 -72.8 -72751 4.1 HDGF FOXA2 ARID4B DMAP1 IRF4 ZNF48 YY1 ZNF143 ATF7 DEK RASAL2 RASAL2-AS1 SEC16B CRYZL2P CRYZL2P-SEC16B GC01M178037
GH01I177974 Enhancer 0.5 ENCODE 9.8 +8.4 8444 1.8 ZFHX2 JUND FOSL2 ZIC2 EGR2 SEC16B CRYZL2P-SEC16B GC01M177906
GH01I177873 Enhancer 0.6 ENCODE 4.5 +110.8 110771 1 NFIB KLF17 ZIC2 ZNF335 HIC1 CTBP1 GATA3 POLR2A GLIS1 FOS SEC16B GC01P177888 LINC01741
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEC16B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC16B gene promoter:

Genomic Locations for SEC16B Gene

Genomic Locations for SEC16B Gene
60,348 bases
Minus strand

Genomic View for SEC16B Gene

Genes around SEC16B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC16B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC16B Gene

Proteins for SEC16B Gene

  • Protein details for SEC16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein transport protein Sec16B
    Protein Accession:
    Secondary Accessions:
    • A3EYF1
    • Q5HYF6
    • Q8N7D6
    • Q96GX6

    Protein attributes for SEC16B Gene

    1060 amino acids
    Molecular mass:
    116604 Da
    Quaternary structure:
    • SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

    Alternative splice isoforms for SEC16B Gene


neXtProt entry for SEC16B Gene

Post-translational modifications for SEC16B Gene

No Post-translational modifications

Other Protein References for SEC16B Gene

No data available for DME Specific Peptides for SEC16B Gene

Domains & Families for SEC16B Gene

Gene Families for SEC16B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SEC16B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC16 family.
  • Belongs to the SEC16 family.
genes like me logo Genes that share domains with SEC16B: view

Function for SEC16B Gene

Molecular function for SEC16B Gene

UniProtKB/Swiss-Prot Function:
Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization.

Phenotypes From GWAS Catalog for SEC16B Gene

genes like me logo Genes that share phenotypes with SEC16B: view

Animal Models for SEC16B Gene

MGI Knock Outs for SEC16B:

Animal Model Products

CRISPR Products

miRNA for SEC16B Gene

miRTarBase miRNAs that target SEC16B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEC16B Gene

Localization for SEC16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC16B Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC16B gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
nucleus 3
golgi apparatus 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Endoplasmic reticulum (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEC16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SEC16B: view

Pathways & Interactions for SEC16B Gene

genes like me logo Genes that share pathways with SEC16B: view

SIGNOR curated interactions for SEC16B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SEC16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007029 endoplasmic reticulum organization IDA 21768384
GO:0007031 peroxisome organization IDA 21768384
GO:0010628 positive regulation of gene expression IMP 21768384
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SEC16B: view

Drugs & Compounds for SEC16B Gene

No Compound Related Data Available

Transcripts for SEC16B Gene

Unigene Clusters for SEC16B Gene

SEC16 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC16B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - - - - - - - - - -
SP2: -
SP4: -
SP5: -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: -

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b · 39c · 39d ^ 40
SP1: - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for SEC16B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC16B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC16B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEC16B Gene

This gene is overexpressed in Liver (x14.1).

Protein differential expression in normal tissues from HIPED for SEC16B Gene

This gene is overexpressed in Liver (42.3), Fetal Liver (16.4), and Pancreas (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEC16B Gene

Protein tissue co-expression partners for SEC16B Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC16B Gene:


SOURCE GeneReport for Unigene cluster for SEC16B Gene:


mRNA Expression by UniProt/SwissProt for SEC16B Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SEC16B Gene

  • Liver(4.4)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with SEC16B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC16B Gene

Orthologs for SEC16B Gene

This gene was present in the common ancestor of animals.

Orthologs for SEC16B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC16B 33
  • 97.79 (n)
(Bos Taurus)
Mammalia SEC16B 33 34
  • 83.48 (n)
(Canis familiaris)
Mammalia SEC16B 33 34
  • 82.98 (n)
(Mus musculus)
Mammalia Sec16b 33 16 34
  • 79.93 (n)
(Rattus norvegicus)
Mammalia Sec16b 33
  • 79.58 (n)
(Monodelphis domestica)
Mammalia SEC16B 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia SEC16B 34
  • 52 (a)
(Gallus gallus)
Aves SEC16B 33 34
  • 61.08 (n)
(Anolis carolinensis)
Reptilia SEC16B 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec16b 33
  • 54.57 (n)
(Danio rerio)
Actinopterygii SEC16B 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sec16 34
  • 10 (a)
(Caenorhabditis elegans)
Secernentea sec-16 34
  • 15 (a)
F13B9.1 34
  • 11 (a)
Species where no ortholog for SEC16B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC16B Gene

Gene Tree for SEC16B (if available)
Gene Tree for SEC16B (if available)

Paralogs for SEC16B Gene

Paralogs for SEC16B Gene

(2) SIMAP similar genes for SEC16B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SEC16B: view

Variants for SEC16B Gene

Sequence variations from dbSNP and Humsavar for SEC16B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000036655 -- 177,956,511(-) C/G intron_variant
rs1000053515 -- 177,938,717(-) T/C intron_variant
rs1000059214 -- 177,963,052(-) G/T intron_variant
rs1000110784 -- 177,950,610(-) A/G intron_variant
rs1000172781 -- 177,934,671(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC16B Gene

Variant ID Type Subtype PubMed ID
nsv548253 CNV loss 21841781
nsv548252 CNV gain 21841781
nsv1010839 CNV loss 25217958
esv2719829 CNV deletion 23290073
esv2663986 CNV deletion 23128226

Variation tolerance for SEC16B Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.53; 95.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC16B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC16B Gene

Disorders for SEC16B Gene

Additional Disease Information for SEC16B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SEC16B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC16B Gene

Publications for SEC16B Gene

  1. Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. (PMID: 11605020) Misawa H … Yamaguchi M (International journal of molecular medicine 2001) 2 3 4 22 58
  2. Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization. (PMID: 17192411) Bhattacharyya D … Glick BS (Molecular biology of the cell 2007) 2 3 4 58
  3. Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells. (PMID: 21768384) Yonekawa S … Tani K (Proceedings of the National Academy of Sciences of the United States of America 2011) 2 3 58
  4. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PMID: 20215397) Ng MC … Ma RC (The Journal of clinical endocrinology and metabolism 2010) 3 44 58
  5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 44 58

Products for SEC16B Gene

Sources for SEC16B Gene

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