Aliases for SEC14L6 Gene

Aliases for SEC14L6 Gene

  • SEC14 Like Lipid Binding 6 2 3 5
  • Putative SEC14-Like Protein 6 3 4
  • SEC14-Like 6 2 3
  • SEC14-Like 6 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 6 2
  • SEC14L6 5

External Ids for SEC14L6 Gene

Previous GeneCards Identifiers for SEC14L6 Gene

  • GC22M030921

Summaries for SEC14L6 Gene

GeneCards Summary for SEC14L6 Gene

SEC14L6 (SEC14 Like Lipid Binding 6) is a Protein Coding gene. Diseases associated with SEC14L6 include Vitamin E, Familial Isolated Deficiency Of. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SEC14L4.

Additional gene information for SEC14L6 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEC14L6 Gene

Genomics for SEC14L6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SEC14L6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC14L6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SEC14L6

Genomic Locations for SEC14L6 Gene

Genomic Locations for SEC14L6 Gene
23,930 bases
Minus strand
23,884 bases
Minus strand

Genomic View for SEC14L6 Gene

Genes around SEC14L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L6 Gene

Proteins for SEC14L6 Gene

  • Protein details for SEC14L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative SEC14-like protein 6
    Protein Accession:

    Protein attributes for SEC14L6 Gene

    397 amino acids
    Molecular mass:
    45364 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEC14L6 Gene

Post-translational modifications for SEC14L6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEC14L6 Gene

Domains & Families for SEC14L6 Gene

Gene Families for SEC14L6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SEC14L6 Gene

Suggested Antigen Peptide Sequences for SEC14L6 Gene

GenScript: Design optimal peptide antigens:
  • Putative SEC14-like protein 6 (S14L6_HUMAN)
genes like me logo Genes that share domains with SEC14L6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SEC14L6 Gene

Function for SEC14L6 Gene

Phenotypes From GWAS Catalog for SEC14L6 Gene

Phenotypes for SEC14L6 Gene

genes like me logo Genes that share phenotypes with SEC14L6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC14L6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L6 Gene

Localization for SEC14L6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L6 gene
Compartment Confidence
cytosol 3
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SEC14L6 Gene

Pathways & Interactions for SEC14L6 Gene

PathCards logo

SuperPathways for SEC14L6 Gene

No Data Available

Interacting Proteins for SEC14L6 Gene

Gene Ontology (GO) - Biological Process for SEC14L6 Gene


No data available for Pathways by source and SIGNOR curated interactions for SEC14L6 Gene

Drugs & Compounds for SEC14L6 Gene

No Compound Related Data Available

Transcripts for SEC14L6 Gene

mRNA/cDNA for SEC14L6 Gene

3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC14L6

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L6 Gene

No ASD Table

Relevant External Links for SEC14L6 Gene

GeneLoc Exon Structure for

Expression for SEC14L6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEC14L6 Gene

mRNA differential expression in normal tissues according to GTEx for SEC14L6 Gene

This gene is overexpressed in Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for SEC14L6 Gene

This gene is overexpressed in Adipocyte (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEC14L6 Gene

Protein tissue co-expression partners for SEC14L6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SEC14L6

SOURCE GeneReport for Unigene cluster for SEC14L6 Gene:

genes like me logo Genes that share expression patterns with SEC14L6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC14L6 Gene

Orthologs for SEC14L6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC14L6 30 31
  • 98.24 (n)
(Bos Taurus)
Mammalia SEC14L6 30
  • 85.23 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 62 (a)
(Gallus gallus)
Aves -- 31
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 59 (a)
(Danio rerio)
Actinopterygii si:ch211-89f7.1 31
  • 57 (a)
FP016199.1 31
  • 51 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG13893 31
  • 28 (a)
(Caenorhabditis elegans)
Secernentea ctg-1 31
  • 26 (a)
F20G2.3 31
  • 24 (a)
ctg-2 31
  • 23 (a)
cgr-1 31
  • 21 (a)
F28H7.8 31
  • 21 (a)
H41C03.1 31
  • 21 (a)
R03A10.5 31
  • 20 (a)
F18A11.2 31
  • 17 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC14 31
  • 25 (a)
-- 31
  • 23 (a)
Species where no ortholog for SEC14L6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SEC14L6 Gene

Gene Tree for SEC14L6 (if available)
Gene Tree for SEC14L6 (if available)
Evolutionary constrained regions (ECRs) for SEC14L6: view image

Paralogs for SEC14L6 Gene

Paralogs for SEC14L6 Gene

(4) SIMAP similar genes for SEC14L6 Gene using alignment to 2 proteins:

  • S14L6_HUMAN
  • H7C077_HUMAN
genes like me logo Genes that share paralogs with SEC14L6: view

Variants for SEC14L6 Gene

Additional dbSNP identifiers (rs#s) for SEC14L6 Gene

Structural Variations from Database of Genomic Variants (DGV) for SEC14L6 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv966101 CNV duplication 23825009

Variation tolerance for SEC14L6 Gene

Gene Damage Index Score: 3.36; 53.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC14L6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SEC14L6 Gene

Disorders for SEC14L6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEC14L6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vitamin e, familial isolated deficiency of
  • ved
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SEC14L6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEC14L6 Gene

Publications for SEC14L6 Gene

  1. The lipid-binding SEC14 domain. (PMID: 17428729) Saito K … Mustelin T (Biochimica et biophysica acta 2007) 2 3
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4

Products for SEC14L6 Gene

Sources for SEC14L6 Gene