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Aliases for SEC14L5 Gene

Aliases for SEC14L5 Gene

  • SEC14 Like Lipid Binding 5 2 3 5
  • SEC14-Like 5 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 5 2
  • SEC14-Like Protein 5 3
  • SEC14-Like 5 3
  • PRELID4B 3
  • KIAA0420 4

External Ids for SEC14L5 Gene

Previous GeneCards Identifiers for SEC14L5 Gene

  • GC16P004932
  • GC16P005008

Summaries for SEC14L5 Gene

GeneCards Summary for SEC14L5 Gene

SEC14L5 (SEC14 Like Lipid Binding 5) is a Protein Coding gene. Diseases associated with SEC14L5 include Post-Traumatic Stress Disorder. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SEC14L1.

Additional gene information for SEC14L5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L5 Gene

Genomics for SEC14L5 Gene

GeneHancer (GH) Regulatory Elements for SEC14L5 Gene

Promoters and enhancers for SEC14L5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I004957 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 557.3 -0.3 -321 1.5 PKNOX1 FOXA2 ZFP64 ZNF133 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143 SEC14L5 SEPT12 PPL GC16M004952
GH16I004956 Enhancer 1.4 Ensembl ENCODE dbSUPER 555.5 -1.9 -1862 0.9 HDGF FOXA2 MLX ARID4B SIN3A ZNF2 IRF4 ZNF48 SLC30A9 ZNF121 SEC14L5 GC16M004952 PPL
GH16I005001 Enhancer 0.6 dbSUPER 21.1 +45.4 45368 3.7 BCOR GATAD2A ZNF3 TEAD1 NR2F1 ZMYM3 CEBPG RARA TBX3 RCOR2 SEC14L5 NAGPA-AS1 GC16P004970
GH16I004110 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 4.6 -844.3 -844319 6.6 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF766 GLIS2 ZNF213 ATF7 RXRA ADCY9 PIR45258 GC16P004115 CREBBP SEC14L5 GC16M004100
GH16I004942 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.5 -13.9 -13944 4.4 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF500 ANKS3 GLYR1 SEPT12 SEC14L5 MGRN1 PPL GC16M004952 GC16P004899
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEC14L5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC14L5 gene promoter:

Genomic Locations for SEC14L5 Gene

Genomic Locations for SEC14L5 Gene
chr16:4,958,317-5,019,158
(GRCh38/hg38)
Size:
60,842 bases
Orientation:
Plus strand
chr16:5,008,318-5,069,159
(GRCh37/hg19)

Genomic View for SEC14L5 Gene

Genes around SEC14L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L5 Gene

Proteins for SEC14L5 Gene

  • Protein details for SEC14L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43304-S14L5_HUMAN
    Recommended name:
    SEC14-like protein 5
    Protein Accession:
    O43304

    Protein attributes for SEC14L5 Gene

    Size:
    696 amino acids
    Molecular mass:
    78942 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24850.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SEC14L5 Gene

Post-translational modifications for SEC14L5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC14L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEC14L5 Gene

Domains & Families for SEC14L5 Gene

Gene Families for SEC14L5 Gene

Suggested Antigen Peptide Sequences for SEC14L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SEC14L5: view

No data available for UniProtKB/Swiss-Prot for SEC14L5 Gene

Function for SEC14L5 Gene

Phenotypes From GWAS Catalog for SEC14L5 Gene

Phenotypes for SEC14L5 Gene

GenomeRNAi human phenotypes for SEC14L5:
genes like me logo Genes that share phenotypes with SEC14L5: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L5 Gene

Localization for SEC14L5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L5 gene
Compartment Confidence
cytosol 4
golgi apparatus 3
mitochondrion 2
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Golgi apparatus (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SEC14L5 Gene

Pathways & Interactions for SEC14L5 Gene

SuperPathways for SEC14L5 Gene

No Data Available

Interacting Proteins for SEC14L5 Gene

Gene Ontology (GO) - Biological Process for SEC14L5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SEC14L5 Gene

Drugs & Compounds for SEC14L5 Gene

No Compound Related Data Available

Transcripts for SEC14L5 Gene

mRNA/cDNA for SEC14L5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(242) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEC14L5 Gene

SEC14-like 5 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L5 Gene

No ASD Table

Relevant External Links for SEC14L5 Gene

GeneLoc Exon Structure for
SEC14L5
ECgene alternative splicing isoforms for
SEC14L5

Expression for SEC14L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC14L5 Gene

mRNA differential expression in normal tissues according to GTEx for SEC14L5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x5.2), Brain - Putamen (basal ganglia) (x4.9), and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for SEC14L5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.8) and Adipocyte (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEC14L5 Gene



Protein tissue co-expression partners for SEC14L5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC14L5 Gene:

SEC14L5

SOURCE GeneReport for Unigene cluster for SEC14L5 Gene:

Hs.512856
genes like me logo Genes that share expression patterns with SEC14L5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC14L5 Gene

Orthologs for SEC14L5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC14L5 33 34
  • 96.79 (n)
dog
(Canis familiaris)
Mammalia SEC14L5 33 34
  • 89.3 (n)
cow
(Bos Taurus)
Mammalia SEC14L5 33 34
  • 88.26 (n)
mouse
(Mus musculus)
Mammalia Sec14l5 33 16 34
  • 84.45 (n)
rat
(Rattus norvegicus)
Mammalia Sec14l5 33
  • 84.2 (n)
oppossum
(Monodelphis domestica)
Mammalia SEC14L5 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC14L5 33 34
  • 74.95 (n)
lizard
(Anolis carolinensis)
Reptilia SEC14L5 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec14l1 33
  • 72.79 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-237i9.1 34
  • 65 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta retm 33 34
  • 57.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RETM_ANOGA 33
  • 54.69 (n)
worm
(Caenorhabditis elegans)
Secernentea T23G5.2 34
  • 45 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKL091C 33
  • 39.34 (n)
SEC14 34
  • 28 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10399 34
  • 53 (a)
OneToMany
Species where no ortholog for SEC14L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC14L5 Gene

ENSEMBL:
Gene Tree for SEC14L5 (if available)
TreeFam:
Gene Tree for SEC14L5 (if available)

Paralogs for SEC14L5 Gene

Paralogs for SEC14L5 Gene

(6) SIMAP similar genes for SEC14L5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SEC14L5: view

Variants for SEC14L5 Gene

Sequence variations from dbSNP and Humsavar for SEC14L5 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000013590 -- 5,013,709(+) C/G intron_variant
rs1000032997 -- 4,987,901(+) G/A intron_variant
rs1000074618 -- 4,983,592(+) T/C intron_variant
rs1000111049 -- 5,012,420(+) A/G intron_variant
rs1000137407 -- 4,958,335(+) G/C/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC14L5 Gene

Variant ID Type Subtype PubMed ID
esv2422516 CNV deletion 17116639
esv25186 CNV gain 19812545
esv2750431 CNV deletion 23290073
esv2750432 CNV deletion 23290073
esv2760069 CNV gain+loss 17122850
esv2761893 CNV loss 21179565
esv34300 CNV gain 17911159
esv3637713 CNV gain 21293372
esv3637714 CNV gain 21293372
esv3892762 CNV gain 25118596
esv3892763 CNV loss 25118596
nsv1038475 CNV gain 25217958
nsv1039432 CNV loss 25217958
nsv1039730 CNV loss 25217958
nsv1042612 CNV loss 25217958
nsv1046986 CNV gain 25217958
nsv1131222 CNV deletion 24896259
nsv428318 CNV gain 18775914
nsv457360 CNV loss 19166990
nsv528586 CNV gain 19592680
nsv571303 CNV loss 21841781
nsv817715 CNV gain 17921354
nsv9339 CNV loss 18304495

Variation tolerance for SEC14L5 Gene

Residual Variation Intolerance Score: 5.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC14L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC14L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L5 Gene

Disorders for SEC14L5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEC14L5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
post-traumatic stress disorder
  • traumatic neurosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SEC14L5

genes like me logo Genes that share disorders with SEC14L5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEC14L5 Gene

Publications for SEC14L5 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. The lipid-binding SEC14 domain. (PMID: 17428729) Saito K … Mustelin T (Biochimica et biophysica acta 2007) 2 3 58
  3. Prediction of Possible Biomarkers and Novel Pathways Conferring Risk to Post-Traumatic Stress Disorder. (PMID: 27997584) Chitrala KN … Nagarkatti M (PloS one 2016) 3 58
  4. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx JJ … Ophoff RA (Molecular psychiatry 2014) 3 58
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 4 58

Products for SEC14L5 Gene

Sources for SEC14L5 Gene

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