Aliases for SEC14L5 Gene

Aliases for SEC14L5 Gene

  • SEC14 Like Lipid Binding 5 2 3 5
  • SEC14-Like Protein 5 3 4
  • PRELID4B 2 3
  • KIAA0420 2 4
  • SEC14-Like 5 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 5 2
  • SEC14-Like 5 3
  • SEC14L5 5

External Ids for SEC14L5 Gene

Previous GeneCards Identifiers for SEC14L5 Gene

  • GC16P004932
  • GC16P005008

Summaries for SEC14L5 Gene

GeneCards Summary for SEC14L5 Gene

SEC14L5 (SEC14 Like Lipid Binding 5) is a Protein Coding gene. Diseases associated with SEC14L5 include Spinocerebellar Ataxia, Autosomal Recessive 12 and Cardiomyopathy, Familial Restrictive, 3. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SEC14L1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEC14L5 Gene

Genomics for SEC14L5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SEC14L5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J004957 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 257.2 -0.3 -305 1.6 SP1 KLF9 ZNF10 YY1 MXD4 CTCF REST ZFP64 MNT SIN3A SEC14L5 HSALNG0109299 lnc-ALG1-4 lnc-NAGPA-2 ZNF500 SEPTIN12 PPL GLYR1
GH16J004934 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 250.4 -21.7 -21709 3.3 CEBPA ZNF10 ATF3 ZIC2 CHD4 YY1 MXD4 CEBPB ZNF341 ZFP64 PPL SEC14L5 SEPTIN12 ENSG00000267077 HSALNG0109297 LOC105371064 GLYR1
GH16J004956 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 255.4 -1.9 -1851 0.9 ZNF654 ZNF600 KLF9 CEBPA CHD4 MXD4 CTCF REST CEBPB KLF11 SEC14L5 lnc-NAGPA-2 RF00019-050 PPL GLYR1
GH16J005001 Enhancer 0.6 dbSUPER 21.1 +45.4 45379 3.7 ZMYM3 CEBPA RARA KDM1A TBX3 ZNF3 NR2F6 ZNF768 CEBPG ARID3A SEC14L5 L13713-082 NAGPA-AS1 ALG1 PPL
GH16J004668 Enhancer 1 Ensembl dbSUPER 10.4 -289.6 -289605 0.6 ZNF148 ZNF521 NBN PAX8 NKRF ESRRA ZNF146 ZNF571 YBX1 HLTF ZNF500 CREBBP MGRN1 ANKS3 ALG1 UBN1 EEF2KMT GLYR1 SEC14L5 MIR6769A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC14L5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SEC14L5

Top Transcription factor binding sites by QIAGEN in the SEC14L5 gene promoter:
  • ARP-1
  • MAZR
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for SEC14L5 Gene

Latest Assembly
60,852 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
60,828 bases
Plus strand

(GRCh37/hg19 by Ensembl)
60,842 bases
Plus strand

Genomic View for SEC14L5 Gene

Genes around SEC14L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L5 Gene

Proteins for SEC14L5 Gene

  • Protein details for SEC14L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SEC14-like protein 5
    Protein Accession:

    Protein attributes for SEC14L5 Gene

    696 amino acids
    Molecular mass:
    78942 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA24850.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SEC14L5 Gene

Post-translational modifications for SEC14L5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC14L5 Gene

No data available for DME Specific Peptides for SEC14L5 Gene

Domains & Families for SEC14L5 Gene

Gene Families for SEC14L5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SEC14L5 Gene

  • Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
  • Cellular retinaldehyde-binding protein signature
  • Cellular retinaldehyde-binding/triple function, N-terminal
  • MSF1-like conserved region

Suggested Antigen Peptide Sequences for SEC14L5 Gene

GenScript: Design optimal peptide antigens:
  • SEC14-like protein 5 (S14L5_HUMAN)
genes like me logo Genes that share domains with SEC14L5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SEC14L5 Gene

Function for SEC14L5 Gene

Phenotypes From GWAS Catalog for SEC14L5 Gene

Gene Ontology (GO) - Molecular Function for SEC14L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with SEC14L5: view

Phenotypes for SEC14L5 Gene

genes like me logo Genes that share phenotypes with SEC14L5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC14L5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L5 Gene

Localization for SEC14L5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L5 gene
Compartment Confidence
cytosol 4
mitochondrion 2
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Golgi apparatus (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SEC14L5 Gene

Pathways & Interactions for SEC14L5 Gene

PathCards logo

SuperPathways for SEC14L5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEC14L5 Gene


No data available for Pathways by source and SIGNOR curated interactions for SEC14L5 Gene

Drugs & Compounds for SEC14L5 Gene

No Compound Related Data Available

Transcripts for SEC14L5 Gene

mRNA/cDNA for SEC14L5 Gene

2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC14L5

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L5 Gene

No ASD Table

Relevant External Links for SEC14L5 Gene

GeneLoc Exon Structure for

Expression for SEC14L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEC14L5 Gene

mRNA differential expression in normal tissues according to GTEx for SEC14L5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x5.2), Brain - Putamen (basal ganglia) (x4.9), and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for SEC14L5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.8) and Adipocyte (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEC14L5 Gene

Protein tissue co-expression partners for SEC14L5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SEC14L5

SOURCE GeneReport for Unigene cluster for SEC14L5 Gene:


Evidence on tissue expression from TISSUES for SEC14L5 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with SEC14L5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC14L5 Gene

Orthologs for SEC14L5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC14L5 29 30
  • 96.79 (n)
(Canis familiaris)
Mammalia SEC14L5 29 30
  • 89.3 (n)
(Bos Taurus)
Mammalia SEC14L5 29 30
  • 88.26 (n)
(Mus musculus)
Mammalia Sec14l5 29 16 30
  • 84.45 (n)
(Rattus norvegicus)
Mammalia Sec14l5 29
  • 84.2 (n)
(Monodelphis domestica)
Mammalia SEC14L5 30
  • 78 (a)
(Gallus gallus)
Aves SEC14L5 29 30
  • 74.95 (n)
(Anolis carolinensis)
Reptilia SEC14L5 30
  • 66 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sec14l1 29
  • 72.79 (n)
(Danio rerio)
Actinopterygii si:dkey-237i9.1 30
  • 65 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta retm 29 30
  • 57.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RETM_ANOGA 29
  • 54.69 (n)
(Caenorhabditis elegans)
Secernentea T23G5.2 30
  • 45 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKL091C 29
  • 39.34 (n)
SEC14 30
  • 28 (a)
-- 30
  • 25 (a)
-- 32
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10399 30
  • 53 (a)
Species where no ortholog for SEC14L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SEC14L5 Gene

Gene Tree for SEC14L5 (if available)
Gene Tree for SEC14L5 (if available)
Evolutionary constrained regions (ECRs) for SEC14L5: view image
Alliance of Genome Resources:
Additional Orthologs for SEC14L5

Paralogs for SEC14L5 Gene

Paralogs for SEC14L5 Gene

(6) SIMAP similar genes for SEC14L5 Gene using alignment to 2 proteins:

  • S14L5_HUMAN
genes like me logo Genes that share paralogs with SEC14L5: view

Variants for SEC14L5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SEC14L5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SEC14L5 Gene

Variant ID Type Subtype PubMed ID
esv2422516 CNV deletion 17116639
esv25186 CNV gain 19812545
esv2750431 CNV deletion 23290073
esv2750432 CNV deletion 23290073
esv2760069 CNV gain+loss 17122850
esv2761893 CNV loss 21179565
esv34300 CNV gain 17911159
esv3637713 CNV gain 21293372
esv3637714 CNV gain 21293372
esv3892762 CNV gain 25118596
esv3892763 CNV loss 25118596
nsv1038475 CNV gain 25217958
nsv1039432 CNV loss 25217958
nsv1039730 CNV loss 25217958
nsv1042612 CNV loss 25217958
nsv1046986 CNV gain 25217958
nsv1131222 CNV deletion 24896259
nsv428318 CNV gain 18775914
nsv457360 CNV loss 19166990
nsv528586 CNV gain 19592680
nsv571303 CNV loss 21841781
nsv817715 CNV gain 17921354
nsv9339 CNV loss 18304495

Variation tolerance for SEC14L5 Gene

Residual Variation Intolerance Score: 5.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC14L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SEC14L5 Gene

Disorders for SEC14L5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SEC14L5 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SEC14L5

genes like me logo Genes that share disorders with SEC14L5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEC14L5 Gene

Publications for SEC14L5 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  2. The lipid-binding SEC14 domain. (PMID: 17428729) Saito K … Mustelin T (Biochimica et biophysica acta 2007) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3. (PMID: 27926873) Jozwik KM … Carroll JS (Cell reports 2016) 3
  5. Prediction of Possible Biomarkers and Novel Pathways Conferring Risk to Post-Traumatic Stress Disorder. (PMID: 27997584) Chitrala KN … Nagarkatti M (PloS one 2016) 3

Products for SEC14L5 Gene

  • Biorbyt antibodies for SEC14L5

Sources for SEC14L5 Gene