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The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
SEC14L4 (SEC14 Like Lipid Binding 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is SEC14L6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008289 | lipid binding | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Vitamin E | Approved, Vet_approved | Nutra | Target | 549,557 | ||
Tocofersolan | Approved | Pharma | Transporter, substrate | 0 | ||
Tocopherol | Approved, Investigational | Pharma | Transporter, substrate | 558 | ||
alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Transporter, substrate | 0 | ||
Squalene | Vet_approved | Pharma | 0 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||
SP2: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SEC14L4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SEC14L4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SEC14L4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Sec14l4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sec14l4 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-89f7.1 31 |
|
ManyToMany | |
FP016199.1 31 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005701 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG13893 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | ctg-1 31 |
|
ManyToMany | |
ctg-2 31 |
|
ManyToMany | |||
H41C03.1 31 |
|
ManyToMany | |||
F20G2.3 31 |
|
ManyToMany | |||
cgr-1 31 |
|
ManyToMany | |||
F18A11.2 31 |
|
ManyToMany | |||
R03A10.5 31 |
|
ManyToMany | |||
F28H7.8 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC14 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17738527 | - |
p.Glu211Lys |
|||
rs17738540 | - |
p.Val200Met |
|||
rs9606739 | - |
p.Arg124Gly |
|||
rs9608956 | - |
p.Ser3Gly |
No disorders were found for SEC14L4 Gene.