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Aliases for SEC14L4 Gene

Aliases for SEC14L4 Gene

  • SEC14 Like Lipid Binding 4 2 3 5
  • Tocopherol-Associated Protein 3 2 3 4
  • TAP3 3 4
  • SEC14-Like 4 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 4 2
  • SEC14p-Like Protein TAP3 3
  • SEC14-Like Protein 4 3
  • SEC14-Like 4 3

External Ids for SEC14L4 Gene

Previous GeneCards Identifiers for SEC14L4 Gene

  • GC22M027579
  • GC22M029209
  • GC22M030884
  • GC22M013847

Summaries for SEC14L4 Gene

Entrez Gene Summary for SEC14L4 Gene

  • The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]

GeneCards Summary for SEC14L4 Gene

SEC14L4 (SEC14 Like Lipid Binding 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is SEC14L6.

UniProtKB/Swiss-Prot for SEC14L4 Gene

  • Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Additional gene information for SEC14L4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L4 Gene

Genomics for SEC14L4 Gene

GeneHancer (GH) Regulatory Elements for SEC14L4 Gene

Promoters and enhancers for SEC14L4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I030504 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 579.2 +0.4 424 1.5 FOXA2 MLX SIN3A DMAP1 ZNF48 RXRA SP5 NFYC ZHX2 MXD4 SEC14L4 SLC35E4 SDC4P
GH22I030234 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.6 +259.0 258981 24.6 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF416 ZNF143 FOS ZNF263 SP5 LIF LOC91370 TUG1 SF3A1 EWSR1 MORC2 PES1 RNF215 TBC1D10A ENSG00000272689
GH22I030278 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 7.5 +226.2 226194 1.1 RFX1 HLF ZMYM3 ZNF121 ZFHX2 POLR2A ZFP36 ZBTB17 EGR2 OSM LIF TBC1D10A SEC14L2 LIF-AS1 ENSG00000249590 SLC35E4 SEC14L4 CASTOR1 MTMR3
GH22I030223 Enhancer 1.3 Ensembl ENCODE dbSUPER 6.7 +279.3 279308 6.5 PKNOX1 FOXA2 GLI4 GLIS2 FOS TSHZ1 SMARCB1 KAT8 GLIS1 KDM1A PES1 MORC2 TUG1 ENSG00000272689 LIF SF3A1 TBC1D10A ENSG00000248751 SEC14L2 ENSG00000249590
GH22I030264 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 4.3 +238.7 238716 4.3 PKNOX1 ATF1 GLIS2 ZNF143 ATF7 RUNX3 CREM SMARCA5 CEBPB ELF1 OSM THOC5 SEC14L4 ENSG00000279699
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEC14L4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC14L4 gene promoter:

Genomic Locations for SEC14L4 Gene

Genomic Locations for SEC14L4 Gene
16,822 bases
Minus strand

Genomic View for SEC14L4 Gene

Genes around SEC14L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L4 Gene

Proteins for SEC14L4 Gene

  • Protein details for SEC14L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SEC14-like protein 4
    Protein Accession:
    Secondary Accessions:
    • A5D6W7
    • A6NCV4

    Protein attributes for SEC14L4 Gene

    406 amino acids
    Molecular mass:
    46644 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SEC14L4 Gene

    Alternative splice isoforms for SEC14L4 Gene


neXtProt entry for SEC14L4 Gene

Post-translational modifications for SEC14L4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SEC14L4 Gene

Domains & Families for SEC14L4 Gene

Gene Families for SEC14L4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SEC14L4: view

No data available for UniProtKB/Swiss-Prot for SEC14L4 Gene

Function for SEC14L4 Gene

Molecular function for SEC14L4 Gene

UniProtKB/Swiss-Prot Function:
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Phenotypes From GWAS Catalog for SEC14L4 Gene

Gene Ontology (GO) - Molecular Function for SEC14L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with SEC14L4: view
genes like me logo Genes that share phenotypes with SEC14L4: view

Animal Model Products

miRNA for SEC14L4 Gene

miRTarBase miRNAs that target SEC14L4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L4 Gene

Localization for SEC14L4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L4 gene
Compartment Confidence
cytosol 3
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SEC14L4 Gene

Pathways & Interactions for SEC14L4 Gene

SuperPathways for SEC14L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEC14L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SEC14L4: view

No data available for Pathways by source and SIGNOR curated interactions for SEC14L4 Gene

Drugs & Compounds for SEC14L4 Gene

(2) Drugs for SEC14L4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 434,438
Squalene Vet_approved Pharma 0
genes like me logo Genes that share compounds with SEC14L4: view

Transcripts for SEC14L4 Gene

Unigene Clusters for SEC14L4 Gene

SEC14-like 4 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: -

Relevant External Links for SEC14L4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC14L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC14L4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEC14L4 Gene

This gene is overexpressed in Liver (x29.4), Testis (x7.3), and Lung (x4.2).

Protein differential expression in normal tissues from HIPED for SEC14L4 Gene

This gene is overexpressed in Liver (20.7), Testis (16.5), Gallbladder (9.9), Ovary (9.2), and Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC14L4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC14L4 Gene:


SOURCE GeneReport for Unigene cluster for SEC14L4 Gene:


Evidence on tissue expression from TISSUES for SEC14L4 Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with SEC14L4: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC14L4 Gene

Orthologs for SEC14L4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC14L4 33 34
  • 98.93 (n)
(Canis familiaris)
Mammalia SEC14L4 33 34
  • 86.78 (n)
(Bos Taurus)
Mammalia SEC14L4 33 34
  • 86.28 (n)
(Mus musculus)
Mammalia Sec14l4 33 16 34
  • 85.32 (n)
(Rattus norvegicus)
Mammalia Sec14l4 33
  • 83.42 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
(Gallus gallus)
Aves -- 34
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
(Danio rerio)
Actinopterygii si:ch211-89f7.1 34
  • 59 (a)
FP016199.1 34
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005701 33
  • 52.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13893 33 34
  • 49.16 (n)
(Caenorhabditis elegans)
Secernentea ctg-1 34
  • 28 (a)
ctg-2 34
  • 24 (a)
H41C03.1 34
  • 23 (a)
cgr-1 34
  • 22 (a)
F20G2.3 34
  • 22 (a)
F18A11.2 34
  • 20 (a)
F28H7.8 34
  • 19 (a)
R03A10.5 34
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC14 34
  • 27 (a)
-- 34
  • 26 (a)
Species where no ortholog for SEC14L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SEC14L4 Gene

Gene Tree for SEC14L4 (if available)
Gene Tree for SEC14L4 (if available)

Paralogs for SEC14L4 Gene

Paralogs for SEC14L4 Gene

(7) SIMAP similar genes for SEC14L4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SEC14L4: view

Variants for SEC14L4 Gene

Sequence variations from dbSNP and Humsavar for SEC14L4 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000181202 -- 30,498,207(-) C/T intron_variant
rs1000451676 -- 30,498,402(-) G/A intron_variant
rs1000457619 -- 30,494,494(-) A/C intron_variant
rs1000475263 -- 30,501,290(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000487328 -- 30,494,772(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC14L4 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv955507 CNV deletion 24416366

Variation tolerance for SEC14L4 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.84; 97.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC14L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L4 Gene

Disorders for SEC14L4 Gene

Additional Disease Information for SEC14L4

No disorders were found for SEC14L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC14L4 Gene

Publications for SEC14L4 Gene

  1. Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. (PMID: 12757856) Kempná P … Azzi A (Free radical biology & medicine 2003) 2 3 4 58
  2. Alternative splicing and gene polymorphism of the human TAP3/SEC14L4 gene. (PMID: 20012369) Kempna P … Zingg JM (Molecular biology reports 2010) 2 3 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 58

Products for SEC14L4 Gene

Sources for SEC14L4 Gene

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