The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has no... See more...

Aliases for SEC14L3 Gene

Aliases for SEC14L3 Gene

  • SEC14 Like Lipid Binding 3 2 3 5
  • Tocopherol-Associated Protein 2 2 3 4
  • TAP2 2 3 4
  • SEC14-Like Protein 3 3 4
  • SEC14-Like 3 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 3 2
  • SEC14p-Like Protein TAP2 3
  • SEC14-Like 3 3
  • SEC14L3 5

External Ids for SEC14L3 Gene

Previous GeneCards Identifiers for SEC14L3 Gene

  • GC22U990252
  • GC22M027553
  • GC22M029180
  • GC22M029179
  • GC22M030843
  • GC22M013816

Summaries for SEC14L3 Gene

Entrez Gene Summary for SEC14L3 Gene

  • The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for SEC14L3 Gene

SEC14L3 (SEC14 Like Lipid Binding 3) is a Protein Coding gene. Diseases associated with SEC14L3 include Palindromic Rheumatism. Gene Ontology (GO) annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is SEC14L2.

UniProtKB/Swiss-Prot Summary for SEC14L3 Gene

  • Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Additional gene information for SEC14L3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEC14L3 Gene

Genomics for SEC14L3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SEC14L3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC14L3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SEC14L3

Top Transcription factor binding sites by QIAGEN in the SEC14L3 gene promoter:
  • AML1a
  • C/EBPalpha
  • HEN1
  • NF-1
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • RelA

Genomic Locations for SEC14L3 Gene

Genomic Locations for SEC14L3 Gene
chr22:30,447,661-30,472,017
(GRCh38/hg38)
Size:
24,357 bases
Orientation:
Minus strand
chr22:30,843,946-30,868,036
(GRCh37/hg19)
Size:
24,091 bases
Orientation:
Minus strand

Genomic View for SEC14L3 Gene

Genes around SEC14L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L3 Gene

Proteins for SEC14L3 Gene

  • Protein details for SEC14L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDX4-S14L3_HUMAN
    Recommended name:
    SEC14-like protein 3
    Protein Accession:
    Q9UDX4
    Secondary Accessions:
    • E7EN74
    • E9PE57
    • Q495V8
    • Q495W0
    • Q495W1

    Protein attributes for SEC14L3 Gene

    Size:
    400 amino acids
    Molecular mass:
    46048 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SEC14L3 Gene

    Alternative splice isoforms for SEC14L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC14L3 Gene

Post-translational modifications for SEC14L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEC14L3 Gene

Domains & Families for SEC14L3 Gene

Gene Families for SEC14L3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SEC14L3 Gene

InterPro:
Blocks:
  • Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
  • Cellular retinaldehyde-binding protein signature
  • Cellular retinaldehyde-binding/triple function, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for SEC14L3 Gene

GenScript: Design optimal peptide antigens:
  • SEC14L3 protein (Q495V9_HUMAN)
  • SEC14L3 protein (Q495W0_HUMAN)
  • SEC14L3 protein (Q495W1_HUMAN)
  • SEC14-like 3 (S. cerevisiae) (Q6ISB2_HUMAN)
  • Tocopherol-associated protein 2 (S14L3_HUMAN)
genes like me logo Genes that share domains with SEC14L3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SEC14L3 Gene

Function for SEC14L3 Gene

Molecular function for SEC14L3 Gene

UniProtKB/Swiss-Prot Function:
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Phenotypes From GWAS Catalog for SEC14L3 Gene

Gene Ontology (GO) - Molecular Function for SEC14L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with SEC14L3: view
genes like me logo Genes that share phenotypes with SEC14L3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEC14L3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC14L3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L3 Gene

Localization for SEC14L3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L3 gene
Compartment Confidence
extracellular 4
cytosol 3
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC14L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with SEC14L3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SEC14L3 Gene

Pathways & Interactions for SEC14L3 Gene

PathCards logo

SuperPathways for SEC14L3 Gene

No Data Available

Interacting Proteins for SEC14L3 Gene

Gene Ontology (GO) - Biological Process for SEC14L3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SEC14L3 Gene

Drugs & Compounds for SEC14L3 Gene

(6) Drugs for SEC14L3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target, Carrier, carrier 526,534
alpha-Tocopherol acetate Approved, Vet_approved Nutra Target, Transporter, substrate 0
Tocofersolan Approved Pharma Transporter, substrate 0
Tocopherol Approved, Investigational Pharma Transporter, substrate 9,535
alpha-Tocopherol succinate Approved, Vet_approved Nutra Target 0
genes like me logo Genes that share compounds with SEC14L3: view

Transcripts for SEC14L3 Gene

mRNA/cDNA for SEC14L3 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC14L3

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3: - -
SP4: - - -

Relevant External Links for SEC14L3 Gene

GeneLoc Exon Structure for
SEC14L3

Expression for SEC14L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEC14L3 Gene

mRNA differential expression in normal tissues according to GTEx for SEC14L3 Gene

This gene is overexpressed in Liver (x26.9), Lung (x6.2), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for SEC14L3 Gene

This gene is overexpressed in Heart (39.6), Brain (12.5), Gallbladder (8.9), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEC14L3 Gene



Protein tissue co-expression partners for SEC14L3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SEC14L3

SOURCE GeneReport for Unigene cluster for SEC14L3 Gene:

Hs.505601
genes like me logo Genes that share expression patterns with SEC14L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC14L3 Gene

Orthologs for SEC14L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SEC14L3 30 31
  • 99.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SEC14L3 30 31
  • 91.42 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SEC14L3 30 31
  • 91.25 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sec14l3 30 17 31
  • 90.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sec14l3 30
  • 90.25 (n)
Oppossum
(Monodelphis domestica)
Mammalia SEC14L3 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SEC14L3 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 59 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 68 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-89f7.1 31
  • 67 (a)
ManyToMany
FP016199.1 31
  • 55 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG13893 31
  • 29 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ctg-1 31
  • 27 (a)
ManyToMany
ctg-2 31
  • 24 (a)
ManyToMany
cgr-1 31
  • 23 (a)
ManyToMany
H41C03.1 31
  • 23 (a)
ManyToMany
F28H7.8 31
  • 22 (a)
ManyToMany
F20G2.3 31
  • 20 (a)
ManyToMany
R03A10.5 31
  • 20 (a)
ManyToMany
F18A11.2 31
  • 19 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC14 31
  • 27 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
Species where no ortholog for SEC14L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SEC14L3 Gene

ENSEMBL:
Gene Tree for SEC14L3 (if available)
TreeFam:
Gene Tree for SEC14L3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEC14L3: view image

Paralogs for SEC14L3 Gene

Paralogs for SEC14L3 Gene

genes like me logo Genes that share paralogs with SEC14L3: view

Variants for SEC14L3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SEC14L3 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs2240345 - p.Asp335Glu
rs2269961 - p.Arg214His
rs35764129 - p.Arg364Cys
rs4820853 - p.Ile103Thr

Additional dbSNP identifiers (rs#s) for SEC14L3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SEC14L3 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv588886 CNV loss 21841781
nsv829171 CNV loss 20364138

Variation tolerance for SEC14L3 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.92; 98.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC14L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC14L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L3 Gene

Disorders for SEC14L3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEC14L3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
palindromic rheumatism
  • hench's syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SEC14L3

genes like me logo Genes that share disorders with SEC14L3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEC14L3 Gene

Publications for SEC14L3 Gene

  1. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. (PMID: 15040456) Ye X … Mao Y (Molecular biology reports 2004) 2 3 23 26
  2. Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. (PMID: 12757856) Kempná P … Azzi A (Free radical biology & medicine 2003) 2 3 4
  3. The lipid-binding SEC14 domain. (PMID: 17428729) Saito K … Mustelin T (Biochimica et biophysica acta 2007) 2 3
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for SEC14L3 Gene

  • Biorbyt antibodies for SEC14L3

Sources for SEC14L3 Gene