Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
SEC14L3 (SEC14 Like Lipid Binding 3) is a Protein Coding gene. Diseases associated with SEC14L3 include Palindromic Rheumatism. Gene Ontology (GO) annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is SEC14L2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008289 | lipid binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0070062 | extracellular exosome | HDA | 23533145 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Vitamin E | Approved, Vet_approved | Nutra | Target, Carrier, carrier | 526,534 | ||
alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Target, Transporter, substrate | 0 | ||
Tocofersolan | Approved | Pharma | Transporter, substrate | 0 | ||
Tocopherol | Approved, Investigational | Pharma | Transporter, substrate | 9,535 | ||
alpha-Tocopherol succinate | Approved, Vet_approved | Nutra | Target | 0 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||
SP4: | - | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SEC14L3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SEC14L3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SEC14L3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Sec14l3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sec14l3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SEC14L3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SEC14L3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-89f7.1 31 |
|
ManyToMany | |
FP016199.1 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG13893 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | ctg-1 31 |
|
ManyToMany | |
ctg-2 31 |
|
ManyToMany | |||
cgr-1 31 |
|
ManyToMany | |||
H41C03.1 31 |
|
ManyToMany | |||
F28H7.8 31 |
|
ManyToMany | |||
F20G2.3 31 |
|
ManyToMany | |||
R03A10.5 31 |
|
ManyToMany | |||
F18A11.2 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC14 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2240345 | - | p.Asp335Glu | |||
rs2269961 | - | p.Arg214His | |||
rs35764129 | - | p.Arg364Cys | |||
rs4820853 | - | p.Ile103Thr |
Disorder | Aliases | PubMed IDs |
---|---|---|
palindromic rheumatism |
|
|