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Aliases for SEC14L3 Gene

Aliases for SEC14L3 Gene

  • SEC14 Like Lipid Binding 3 2 3 5
  • Tocopherol-Associated Protein 2 2 3 4
  • TAP2 3 4
  • SEC14-Like 3 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 3 2
  • SEC14p-Like Protein TAP2 3
  • SEC14-Like Protein 3 3
  • SEC14-Like 3 3

External Ids for SEC14L3 Gene

Previous GeneCards Identifiers for SEC14L3 Gene

  • GC22U990252
  • GC22M027553
  • GC22M029180
  • GC22M029179
  • GC22M030843
  • GC22M013816

Summaries for SEC14L3 Gene

Entrez Gene Summary for SEC14L3 Gene

  • The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for SEC14L3 Gene

SEC14L3 (SEC14 Like Lipid Binding 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is SEC14L2.

UniProtKB/Swiss-Prot for SEC14L3 Gene

  • Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Additional gene information for SEC14L3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L3 Gene

Genomics for SEC14L3 Gene

GeneHancer (GH) Regulatory Elements for SEC14L3 Gene

Promoters and enhancers for SEC14L3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I030473 Enhancer 0.2 ENCODE 550.8 -1.5 -1460 0.2 ENSG00000181123 SEC14L3 SEC14L4 SEC14L2 ENSG00000249590 TBC1D10A ENSG00000248751
GH22I030415 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.2 +50.6 50610 11.6 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 RNF215 ENSG00000272689 ENSG00000273350 MTFP1 RNU6-564P TUG1 SF3A1 TBC1D10A SEC14L3 PES1
GH22I030322 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.1 +145.1 145129 8 HDGF PKNOX1 ARID4B SIN3A YY1 GLIS2 ZNF213 ATF7 RUNX3 SP3 TBC1D10A RNF215 CCDC157 CASTOR1 SEC14L3 TUG1 SF3A1 ENSG00000248751 SEC14L2 ENSG00000249590
GH22I030444 Enhancer 1.2 Ensembl ENCODE dbSUPER 33.2 +26.5 26517 1.6 ZNF76 SIN3A RAD21 YY1 ZNF335 EGR1 ZNF143 FOS ETV6 BCLAF1 SEC14L3 TUG1 TBC1D10A PATZ1 SF3A1 PES1 ENSG00000181123 SEC14L2 ENSG00000249590 LIF
GH22I030434 Enhancer 1.2 Ensembl ENCODE dbSUPER 21 +36.6 36558 2.3 ATF1 FOXA2 ZBTB40 RARA ETS1 ZNF335 E2F8 ATF7 ETV6 THAP11 GC22P030436 SEC14L3 SEC14L2 ENSG00000249590 CASTOR1 SMTN LOC105372990 PIR31582
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEC14L3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC14L3 gene promoter:

Genomic Locations for SEC14L3 Gene

Genomic Locations for SEC14L3 Gene
24,091 bases
Minus strand

Genomic View for SEC14L3 Gene

Genes around SEC14L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L3 Gene

Proteins for SEC14L3 Gene

  • Protein details for SEC14L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SEC14-like protein 3
    Protein Accession:
    Secondary Accessions:
    • E7EN74
    • E9PE57
    • Q495V8
    • Q495W0
    • Q495W1

    Protein attributes for SEC14L3 Gene

    400 amino acids
    Molecular mass:
    46048 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SEC14L3 Gene

    Alternative splice isoforms for SEC14L3 Gene


neXtProt entry for SEC14L3 Gene

Post-translational modifications for SEC14L3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SEC14L3 Gene

Domains & Families for SEC14L3 Gene

Gene Families for SEC14L3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SEC14L3: view

No data available for UniProtKB/Swiss-Prot for SEC14L3 Gene

Function for SEC14L3 Gene

Molecular function for SEC14L3 Gene

UniProtKB/Swiss-Prot Function:
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Phenotypes From GWAS Catalog for SEC14L3 Gene

Gene Ontology (GO) - Molecular Function for SEC14L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with SEC14L3: view
genes like me logo Genes that share phenotypes with SEC14L3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L3 Gene

Localization for SEC14L3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L3 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEC14L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with SEC14L3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SEC14L3 Gene

Pathways & Interactions for SEC14L3 Gene

SuperPathways for SEC14L3 Gene

No Data Available

Interacting Proteins for SEC14L3 Gene

Gene Ontology (GO) - Biological Process for SEC14L3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SEC14L3 Gene

Drugs & Compounds for SEC14L3 Gene

(2) Drugs for SEC14L3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 434,438
Squalene Vet_approved Pharma 0
genes like me logo Genes that share compounds with SEC14L3: view

Transcripts for SEC14L3 Gene

Unigene Clusters for SEC14L3 Gene

SEC14-like 3 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3: - -
SP4: - - -

Relevant External Links for SEC14L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC14L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC14L3 Gene

mRNA differential expression in normal tissues according to GTEx for SEC14L3 Gene

This gene is overexpressed in Liver (x26.9), Lung (x6.2), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for SEC14L3 Gene

This gene is overexpressed in Heart (39.6), Brain (12.5), Gallbladder (8.9), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEC14L3 Gene

Protein tissue co-expression partners for SEC14L3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC14L3 Gene:


SOURCE GeneReport for Unigene cluster for SEC14L3 Gene:

genes like me logo Genes that share expression patterns with SEC14L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC14L3 Gene

Orthologs for SEC14L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC14L3 33 34
  • 99.25 (n)
(Bos Taurus)
Mammalia SEC14L3 33 34
  • 91.42 (n)
(Canis familiaris)
Mammalia SEC14L3 33 34
  • 91.25 (n)
(Mus musculus)
Mammalia Sec14l3 33 16 34
  • 90.58 (n)
(Rattus norvegicus)
Mammalia Sec14l3 33
  • 90.25 (n)
(Monodelphis domestica)
Mammalia SEC14L3 34
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SEC14L3 34
  • 84 (a)
(Gallus gallus)
Aves -- 34
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
(Danio rerio)
Actinopterygii si:ch211-89f7.1 34
  • 67 (a)
FP016199.1 34
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13893 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea ctg-1 34
  • 27 (a)
ctg-2 34
  • 24 (a)
cgr-1 34
  • 23 (a)
H41C03.1 34
  • 23 (a)
F28H7.8 34
  • 22 (a)
F20G2.3 34
  • 20 (a)
R03A10.5 34
  • 20 (a)
F18A11.2 34
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC14 34
  • 27 (a)
-- 34
  • 25 (a)
Species where no ortholog for SEC14L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SEC14L3 Gene

Gene Tree for SEC14L3 (if available)
Gene Tree for SEC14L3 (if available)

Paralogs for SEC14L3 Gene

Paralogs for SEC14L3 Gene

genes like me logo Genes that share paralogs with SEC14L3: view

Variants for SEC14L3 Gene

Sequence variations from dbSNP and Humsavar for SEC14L3 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000098988 -- 30,471,545(-) G/C intron_variant
rs1000264399 -- 30,465,619(-) A/G intron_variant
rs1000298700 -- 30,470,048(-) C/G 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000370524 -- 30,458,063(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000398569 -- 30,459,076(-) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC14L3 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv588886 CNV loss 21841781
nsv829171 CNV loss 20364138

Variation tolerance for SEC14L3 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.92; 98.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC14L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L3 Gene

Disorders for SEC14L3 Gene

Additional Disease Information for SEC14L3

No disorders were found for SEC14L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC14L3 Gene

Publications for SEC14L3 Gene

  1. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. (PMID: 15040456) Ye X … Mao Y (Molecular biology reports 2004) 2 3 22 25 58
  2. Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. (PMID: 12757856) Kempná P … Azzi A (Free radical biology & medicine 2003) 2 3 4 58
  3. The lipid-binding SEC14 domain. (PMID: 17428729) Saito K … Mustelin T (Biochimica et biophysica acta 2007) 2 3 58
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SEC14L3 Gene

Sources for SEC14L3 Gene

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