Aliases for SEC11C Gene

Aliases for SEC11C Gene

  • SEC11 Homolog C, Signal Peptidase Complex Subunit 2 3 5
  • Signal Peptidase Complex Catalytic Subunit SEC11C 3 4
  • Microsomal Signal Peptidase 21 KDa Subunit 3 4
  • Signal Peptidase Complex 21 2 3
  • SEC11-Like Protein 3 3 4
  • SPase 21 KDa Subunit 3 4
  • SEC11L3 3 4
  • SPCS4C 3 4
  • SPC21 3 4
  • SEC11 Homolog C (S. Cerevisiae) 2
  • SEC11-Like 3 (S. Cerevisiae) 2
  • SEC11 Homolog C 4
  • SEC11-Like 3 3
  • EC 4

External Ids for SEC11C Gene

Previous HGNC Symbols for SEC11C Gene

  • SEC11L3

Previous GeneCards Identifiers for SEC11C Gene

  • GC18P054960
  • GC18P056807
  • GC18P053515

Summaries for SEC11C Gene

GeneCards Summary for SEC11C Gene

SEC11C (SEC11 Homolog C, Signal Peptidase Complex Subunit) is a Protein Coding gene. Among its related pathways are Incretin synthesis, secretion, and inactivation and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include peptidase activity and serine-type peptidase activity. An important paralog of this gene is SEC11A.

UniProtKB/Swiss-Prot Summary for SEC11C Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Additional gene information for SEC11C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEC11C Gene

Genomics for SEC11C Gene

GeneHancer (GH) Regulatory Elements for SEC11C Gene

Promoters and enhancers for SEC11C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J059138 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 761.7 +1.4 1426 4.7 SP1 SIX5 FOXA1 RBPJ POLR2A USF2 NR2F6 CREB1 HCFC1 MIXL1 SEC11C NONHSAG023978.2 ZNF532 GRP MALT1 lnc-SEC11C-1
GH18J059123 Enhancer 0.7 Ensembl ENCODE 10.3 -15.9 -15912 1.3 SP7 POLR2A ZBTB48 FOS JUNB FOSL2 ZNF335 BATF JUND ZNF398 SEC11C HSALNG0121850
GH18J059155 Enhancer 0.6 Ensembl ENCODE 6.7 +15.4 15356 0.8 POLR2A FOS JUND GRP SEC11C lnc-SEC11C-1 NONHSAG023978.2
GH18J059147 Enhancer 0.2 Ensembl 10.9 +7.2 7235 0.2 SEC11C NONHSAG023978.2 lnc-SEC11C-1
GH18J059150 Enhancer 0.2 Ensembl 10.7 +10.4 10416 0.6 GRP SEC11C lnc-SEC11C-1 NONHSAG023978.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC11C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC11C gene promoter:
  • Egr-4
  • HSF1 (long)
  • HSF1short
  • HSF2
  • Pax-2
  • Pax-2a
  • Pax-4a
  • POU2F1
  • POU2F1a
  • SEF-1 (1)

Genomic Locations for SEC11C Gene

Genomic Locations for SEC11C Gene
18,972 bases
Plus strand
19,360 bases
Plus strand

Genomic View for SEC11C Gene

Genes around SEC11C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC11C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC11C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC11C Gene

Proteins for SEC11C Gene

  • Protein details for SEC11C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal peptidase complex catalytic subunit SEC11C
    Protein Accession:
    Secondary Accessions:
    • B2RAA3

    Protein attributes for SEC11C Gene

    192 amino acids
    Molecular mass:
    21542 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

neXtProt entry for SEC11C Gene

Post-translational modifications for SEC11C Gene

  • Ubiquitination at Lys98, Lys122, Lys126, and Lys139
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC11C Gene

No data available for DME Specific Peptides for SEC11C Gene

Domains & Families for SEC11C Gene

Gene Families for SEC11C Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SEC11C Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57851, highly similar to Microsomal signal peptidase 21 kDa subunit (EC 3.4.-.-) (B4DI03_HUMAN)
  • SPC21 (SC11C_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S26B family.
  • Belongs to the peptidase S26B family.
genes like me logo Genes that share domains with SEC11C: view

Function for SEC11C Gene

Molecular function for SEC11C Gene

UniProtKB/Swiss-Prot Function:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.; EC=;.

Enzyme Numbers (IUBMB) for SEC11C Gene

Phenotypes From GWAS Catalog for SEC11C Gene

Gene Ontology (GO) - Molecular Function for SEC11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IBA,IEA 21873635
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SEC11C: view
genes like me logo Genes that share phenotypes with SEC11C: view

Animal Models for SEC11C Gene

MGI Knock Outs for SEC11C:
  • Sec11c Sec11c<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for SEC11C

CRISPR Products

miRNA for SEC11C Gene

miRTarBase miRNAs that target SEC11C

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEC11C Gene

Localization for SEC11C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC11C Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC11C gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 2
cytosol 2
mitochondrion 1
golgi apparatus 1
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEC11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005787 signal peptidase complex IBA,IEA 21873635
GO:0005789 endoplasmic reticulum membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with SEC11C: view

Pathways & Interactions for SEC11C Gene

genes like me logo Genes that share pathways with SEC11C: view

Gene Ontology (GO) - Biological Process for SEC11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IBA,IEA 21873635
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with SEC11C: view

No data available for SIGNOR curated interactions for SEC11C Gene

Drugs & Compounds for SEC11C Gene

No Compound Related Data Available

Transcripts for SEC11C Gene

mRNA/cDNA for SEC11C Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC11C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -

Relevant External Links for SEC11C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC11C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC11C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC11C Gene

This gene is overexpressed in Nasal epithelium (42.3) and Salivary gland (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEC11C Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC11C Gene:


SOURCE GeneReport for Unigene cluster for SEC11C Gene:


Evidence on tissue expression from TISSUES for SEC11C Gene

  • Pancreas(4.7)
  • Nervous system(4.6)
  • Liver(2.6)
  • Lung(2.4)
  • Spleen(2.1)
  • Kidney(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SEC11C: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC11C Gene

Orthologs for SEC11C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC11C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC11C 33
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia SEC11C 33
  • 94 (a)
(Canis familiaris)
Mammalia SEC11C 33 32
  • 93.06 (n)
(Mus musculus)
Mammalia Sec11c 17 33 32
  • 92.19 (n)
(Bos Taurus)
Mammalia SEC11C 33 32
  • 92.01 (n)
(Rattus norvegicus)
Mammalia Sec11c 32
  • 91.15 (n)
(Monodelphis domestica)
Mammalia SEC11C 33
  • 84 (a)
(Gallus gallus)
Aves SEC11C 33 32
  • 85.69 (n)
(Anolis carolinensis)
Reptilia SEC11C 33
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec11c 32
  • 79.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta twr 33 32
  • 67.43 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003069 32
  • 66.08 (n)
(Caenorhabditis elegans)
Secernentea Y54E10BR.5 33
  • 68 (a)
CELE_Y54E10BR.5 32
  • 63.43 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18261g 32
  • 54.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC11 33 32
  • 52.73 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR158W 32
  • 50.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15710 32
  • 61.74 (n)
(Hordeum vulgare)
Liliopsida Hv.2895 32
(Triticum aestivum)
Liliopsida Ta.6431 32
(Oryza sativa)
Liliopsida Os.10990 32
(Zea mays)
Liliopsida Zm.1761 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5539 33
  • 78 (a)
Cin.133 32
bread mold
(Neurospora crassa)
Ascomycetes NCU04519 32
  • 56.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec11 32
  • 51.68 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.133 32
Species where no ortholog for SEC11C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • zebrafish (Danio rerio)

Evolution for SEC11C Gene

Gene Tree for SEC11C (if available)
Gene Tree for SEC11C (if available)
Evolutionary constrained regions (ECRs) for SEC11C: view image

Paralogs for SEC11C Gene

Paralogs for SEC11C Gene

(4) SIMAP similar genes for SEC11C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SEC11C: view

Variants for SEC11C Gene

Sequence variations from dbSNP and Humsavar for SEC11C Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000206906 -- 59,144,801(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000297906 -- 59,150,744(+) T/C intron_variant
rs1000393005 -- 59,150,474(+) C/G intron_variant
rs1000429786 -- 59,158,944(+) A/G downstream_transcript_variant
rs1000459211 -- 59,157,841(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC11C Gene

Variant ID Type Subtype PubMed ID
esv3304149 CNV mobile element insertion 20981092
esv3402573 CNV insertion 20981092

Variation tolerance for SEC11C Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC11C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC11C Gene

Disorders for SEC11C Gene

Additional Disease Information for SEC11C

No disorders were found for SEC11C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC11C Gene

Publications for SEC11C Gene

  1. Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer. (PMID: 23995782) Oue N … Yasui W (Oncogene 2014) 2 3 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein. (PMID: 2188978) Shelness GS … Blobel G (The Journal of biological chemistry 1990) 2 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56

Products for SEC11C Gene

Sources for SEC11C Gene