Aliases for SEC11A Gene
External Ids for SEC11A Gene
Previous HGNC Symbols for SEC11A Gene
Previous GeneCards Identifiers for SEC11A Gene
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
GeneCards Summary for SEC11A Gene
SEC11A (SEC11 Homolog A, Signal Peptidase Complex Subunit) is a Protein Coding gene. Among its related pathways are Incretin synthesis, secretion, and inactivation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include peptidase activity and serine-type peptidase activity. An important paralog of this gene is SEC11C.
UniProtKB/Swiss-Prot Summary for SEC11A Gene
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.