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Aliases for SEC11A Gene

Aliases for SEC11A Gene

  • SEC11 Homolog A, Signal Peptidase Complex Subunit 2 3 5
  • Microsomal Signal Peptidase 18 KDa Subunit 3 4
  • Signal Peptidase Complex 18 2 3
  • SEC11-Like Protein 1 3 4
  • SPase 18 KDa Subunit 3 4
  • Endopeptidase SP18 3 4
  • SEC11L1 3 4
  • SPCS4A 3 4
  • SPC18 3 4
  • Signal Peptidase Complex Catalytic Subunit SEC11A 3
  • Signal Peptidase Complex (18kD) 3
  • SEC11 Homolog A (S. Cerevisiae) 2
  • SEC11-Like 1 (S. Cerevisiae) 2
  • SEC11 Homolog A 4
  • 1810012E07Rik 3
  • EC 3.4.21.89 4
  • Sid2895 3

External Ids for SEC11A Gene

Previous HGNC Symbols for SEC11A Gene

  • SEC11L1

Previous GeneCards Identifiers for SEC11A Gene

  • GC15M083015
  • GC15M085212

Summaries for SEC11A Gene

Entrez Gene Summary for SEC11A Gene

  • This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]

GeneCards Summary for SEC11A Gene

SEC11A (SEC11 Homolog A, Signal Peptidase Complex Subunit) is a Protein Coding gene. Among its related pathways are Incretin synthesis, secretion, and inactivation and Protein export. Gene Ontology (GO) annotations related to this gene include peptidase activity and serine-type peptidase activity. An important paralog of this gene is SEC11C.

UniProtKB/Swiss-Prot for SEC11A Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Additional gene information for SEC11A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC11A Gene

Genomics for SEC11A Gene

GeneHancer (GH) Regulatory Elements for SEC11A Gene

Promoters and enhancers for SEC11A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J084714 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 755 3.4 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF548 SP3 SEC11A SCAND2P WDR73 NMB GOLGA6L5P ZNF592 LINC00933 UBE2Q2P1 GOLGA6L4 CSPG4P12
GH15J084695 Promoter 0.5 EPDnew 662.7 +20.9 20909 0.1 SEC11A NMB WDR73 ALPK3 ZNF592 ENSG00000200991 ENSG00000259654
GH15J084816 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -104.7 -104692 9.6 HDGF FOXA2 ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF143 RXRA MXD4 WDR73 ZNF592 ALPK3 NMB GOLGA6L5P ENSG00000200991 SLC28A1 GOLGA6L3 SEC11A ENSG00000259683
GH15J084685 Enhancer 0.9 ENCODE dbSUPER 12.2 +31.1 31134 0.6 ZSCAN5A KLF1 ZBTB6 JUN ZNF384 FOSL1 FOSL2 FOS ZNF639 ZNF362 ENSG00000259654 NMB WDR73 SEC11A ALPK3 GC15M084670
GH15J084987 Enhancer 0.9 Ensembl ENCODE dbSUPER 10.5 -271.9 -271856 1.6 ZNF664 ZNF362 ZBTB48 EED EBF1 ETV6 SPI1 LOC101929479 SEC11A GOLGA6L3 ENSG00000259276 PDE8A GC15P085002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC11A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC11A gene promoter:
  • AP-1
  • STAT1beta
  • STAT1alpha
  • STAT1
  • PPAR-gamma1
  • PPAR-gamma2
  • Arnt
  • POU2F1a
  • POU2F1
  • c-Ets-1

Genomic Locations for SEC11A Gene

Genomic Locations for SEC11A Gene
chr15:84,669,537-84,716,716
(GRCh38/hg38)
Size:
47,180 bases
Orientation:
Minus strand
chr15:85,212,775-85,259,947
(GRCh37/hg19)
Size:
47,173 bases
Orientation:
Minus strand

Genomic View for SEC11A Gene

Genes around SEC11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC11A Gene

Proteins for SEC11A Gene

  • Protein details for SEC11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67812-SC11A_HUMAN
    Recommended name:
    Signal peptidase complex catalytic subunit SEC11A
    Protein Accession:
    P67812
    Secondary Accessions:
    • B2RAD7
    • B4DUL4
    • H0YK72
    • H0YK83
    • O75957
    • P21378
    • Q53FQ8

    Protein attributes for SEC11A Gene

    Size:
    179 amino acids
    Molecular mass:
    20625 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

    Alternative splice isoforms for SEC11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC11A Gene

Post-translational modifications for SEC11A Gene

  • Ubiquitination at isoforms=2, 3, 4127
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEC11A Gene

Domains & Families for SEC11A Gene

Gene Families for SEC11A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SEC11A Gene

Graphical View of Domain Structure for InterPro Entry

P67812

UniProtKB/Swiss-Prot:

SC11A_HUMAN :
  • Belongs to the peptidase S26B family.
Family:
  • Belongs to the peptidase S26B family.
genes like me logo Genes that share domains with SEC11A: view

Function for SEC11A Gene

Molecular function for SEC11A Gene

UniProtKB/Swiss-Prot Function:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Enzyme Numbers (IUBMB) for SEC11A Gene

Phenotypes From GWAS Catalog for SEC11A Gene

Gene Ontology (GO) - Molecular Function for SEC11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IBA,IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SEC11A: view
genes like me logo Genes that share phenotypes with SEC11A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEC11A

miRNA for SEC11A Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC11A Gene

Localization for SEC11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC11A Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC11A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEC11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005787 signal peptidase complex IEA,IBA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with SEC11A: view

Pathways & Interactions for SEC11A Gene

genes like me logo Genes that share pathways with SEC11A: view

Gene Ontology (GO) - Biological Process for SEC11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IEA,IBA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with SEC11A: view

No data available for SIGNOR curated interactions for SEC11A Gene

Drugs & Compounds for SEC11A Gene

No Compound Related Data Available

Transcripts for SEC11A Gene

Unigene Clusters for SEC11A Gene

SEC11 homolog A (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC11A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -

Relevant External Links for SEC11A Gene

GeneLoc Exon Structure for
SEC11A
ECgene alternative splicing isoforms for
SEC11A

Expression for SEC11A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC11A Gene

This gene is overexpressed in Nasal epithelium (33.8) and Tlymphocyte (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEC11A Gene



Protein tissue co-expression partners for SEC11A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC11A Gene:

SEC11A

SOURCE GeneReport for Unigene cluster for SEC11A Gene:

Hs.9534

Evidence on tissue expression from TISSUES for SEC11A Gene

  • Intestine(4.6)
  • Liver(4.4)
  • Muscle(4.4)
  • Stomach(4.4)
  • Nervous system(3.7)
  • Pancreas(2.1)
  • Thyroid gland(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with SEC11A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC11A Gene

Orthologs for SEC11A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC11A 34 33
  • 99.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SEC11A 34 33
  • 97.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SEC11A 34 33
  • 95.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sec11a 16 34 33
  • 90.88 (n)
rat
(Rattus norvegicus)
Mammalia Sec11a 33
  • 90.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SEC11A 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC11A 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC11A 34 33
  • 82.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC11A 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec11a 33
  • 78.77 (n)
MGC76332 33
zebrafish
(Danio rerio)
Actinopterygii sec11a 34 33
  • 80.45 (n)
OneToOne
Dr.7472 33
fruit fly
(Drosophila melanogaster)
Insecta twr 34
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54E10BR.5 34
  • 67 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC11 36 34
  • 46 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G52600 33
  • 62.47 (n)
rice
(Oryza sativa)
Liliopsida Os06g0273800 33
  • 63.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5539 34
  • 76 (a)
OneToMany
Species where no ortholog for SEC11A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC11A Gene

ENSEMBL:
Gene Tree for SEC11A (if available)
TreeFam:
Gene Tree for SEC11A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEC11A: view image

Paralogs for SEC11A Gene

Paralogs for SEC11A Gene

(4) SIMAP similar genes for SEC11A Gene using alignment to 8 proteins:

  • SC11A_HUMAN
  • B4DUL4_HUMAN
  • H0YK72_HUMAN
  • H0YK83_HUMAN
  • H0YKT4_HUMAN
  • H0YNA5_HUMAN
  • H0YNG3_HUMAN
  • H0YNX5_HUMAN

Pseudogenes.org Pseudogenes for SEC11A Gene

genes like me logo Genes that share paralogs with SEC11A: view

Variants for SEC11A Gene

Sequence variations from dbSNP and Humsavar for SEC11A Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000009632 -- 84,704,720(-) C/T intron_variant
rs1000082773 -- 84,697,235(-) A/C intron_variant
rs1000111383 -- 84,677,824(-) A/G intron_variant
rs1000135227 -- 84,690,205(-) T/C intron_variant
rs1000215557 -- 84,686,920(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC11A Gene

Variant ID Type Subtype PubMed ID
esv2672412 CNV deletion 23128226
esv2672879 CNV deletion 23128226
esv3637095 CNV gain 21293372
esv3637097 CNV gain 21293372
esv3637098 CNV loss 21293372
nsv1134478 CNV deletion 24896259
nsv428310 CNV gain+loss 18775914

Variation tolerance for SEC11A Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC11A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC11A Gene

Disorders for SEC11A Gene

Additional Disease Information for SEC11A

No disorders were found for SEC11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC11A Gene

Publications for SEC11A Gene

  1. Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer. (PMID: 23995782) Oue N … Yasui W (Oncogene 2014) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein. (PMID: 2188978) Shelness GS … Blobel G (The Journal of biological chemistry 1990) 2 3 58
  4. Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression. (PMID: 27859949) Hattori T … Yasui W (Cancer science 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SEC11A Gene

Sources for SEC11A Gene

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