Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008] See more...

Aliases for SEBOX Gene

Aliases for SEBOX Gene

  • SEBOX Homeobox 2 3 5
  • Skin-, Embryo-, Brain- And Oocyte-Specific Homeobox 3 4
  • Homeobox Protein SEBOX 3 4
  • Homeobox OG-9 3 4
  • OG9X 3 4
  • OG-9 3
  • OG9 3

External Ids for SEBOX Gene

Previous GeneCards Identifiers for SEBOX Gene

  • GC17M023716
  • GC17M026691
  • GC17M028367
  • GC17M028456
  • GC17M029278
  • GC17M029378
  • GC17M028537
  • GC17M028624
  • GC17M028709
  • GC17M028805
  • GC17M028910
  • GC17M029003
  • GC17M029104
  • GC17M029188

Summaries for SEBOX Gene

Entrez Gene Summary for SEBOX Gene

  • Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SEBOX Gene

SEBOX (SEBOX Homeobox) is a Protein Coding gene. An important paralog of this gene is PROP1.

UniProtKB/Swiss-Prot Summary for SEBOX Gene

  • Probable transcription factor involved in the control of specification of mesoderm and endoderm.

Additional gene information for SEBOX Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SEBOX Gene

Genomics for SEBOX Gene

GeneHancer (GH) Regulatory Elements for SEBOX Gene

Promoters and enhancers for SEBOX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J027950 Enhancer 0.6 FANTOM5 Ensembl ENCODE 14 +413.3 413332 2.2 ZNF623 SEBOX NOS2 piR-43105-268 LINC01992
GH17J028499 Enhancer 1.1 FANTOM5 Ensembl ENCODE 1.8 -135.7 -135718 2.5 RELA MAX POLR2A MLLT1 ZNF687 IKZF1 ZIC2 BACH1 SP2 EED ENSG00000264577 ENSG00000265205 ENSG00000265908 NUFIP2 ITM2BP1 UNC119 RPL23A SDF2 LOC101927018 PIGS
GH17J028391 Enhancer 0.3 FANTOM5 3.3 -26.6 -26558 0.2 L3MBTL2 SEBOX SARM1 FOXN1 FAM222B NONHSAG021298.2 lnc-VTN-1 ENSG00000279532
GH17J028777 Enhancer 0.7 FANTOM5 Ensembl 1.5 -412.8 -412757 2.8 ZNF362 ZNF316 NFE2 SCRT2 SCRT1 ARNT ZNF18 EMSY PROCA1 TRAF4 ABHD15 SEBOX piR-60051-041 RPL31P58 RF00017-2319 FAM222B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEBOX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEBOX gene promoter:
  • ATF
  • NF-kappaB
  • NRSF form 1
  • NRSF form 2
  • p300

Genomic Locations for SEBOX Gene

Genomic Locations for SEBOX Gene
chr17:28,364,268-28,365,244
(GRCh38/hg38)
Size:
977 bases
Orientation:
Minus strand
chr17:26,691,290-26,700,110
(GRCh37/hg19)
Size:
8,821 bases
Orientation:
Minus strand

Genomic View for SEBOX Gene

Genes around SEBOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEBOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEBOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEBOX Gene

Proteins for SEBOX Gene

  • Protein details for SEBOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB31-SEBOX_HUMAN
    Recommended name:
    Homeobox protein SEBOX
    Protein Accession:
    Q9HB31

    Protein attributes for SEBOX Gene

    Size:
    216 amino acids
    Molecular mass:
    22879 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG14458.1; Type=Frameshift; Positions=9; Evidence={ECO:0000305}; Sequence=EAW51081.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SEBOX Gene

Post-translational modifications for SEBOX Gene

No Post-translational modifications

Other Protein References for SEBOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEBOX Gene

Domains & Families for SEBOX Gene

Gene Families for SEBOX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SEBOX Gene

Suggested Antigen Peptide Sequences for SEBOX Gene

GenScript: Design optimal peptide antigens:
  • Skin-, embryo-, brain- and oocyte-specific homeobox (SEBOX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HB31

UniProtKB/Swiss-Prot:

SEBOX_HUMAN :
  • Belongs to the paired homeobox family.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with SEBOX: view

Function for SEBOX Gene

Molecular function for SEBOX Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in the control of specification of mesoderm and endoderm.

Phenotypes From GWAS Catalog for SEBOX Gene

Gene Ontology (GO) - Molecular Function for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with SEBOX: view
genes like me logo Genes that share phenotypes with SEBOX: view

Animal Models for SEBOX Gene

MGI Knock Outs for SEBOX:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SEBOX Gene

Localization for SEBOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEBOX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEBOX gene
Compartment Confidence
nucleus 3
extracellular 2
lysosome 0

Gene Ontology (GO) - Cellular Components for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SEBOX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEBOX Gene

Pathways & Interactions for SEBOX Gene

PathCards logo

SuperPathways for SEBOX Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
GO:0009792 embryo development ending in birth or egg hatching IEA --
GO:0030154 cell differentiation IEA --
GO:0048477 oogenesis IEA --
genes like me logo Genes that share ontologies with SEBOX: view

No data available for Pathways by source and SIGNOR curated interactions for SEBOX Gene

Drugs & Compounds for SEBOX Gene

No Compound Related Data Available

Transcripts for SEBOX Gene

mRNA/cDNA for SEBOX Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEBOX Gene

No ASD Table

Relevant External Links for SEBOX Gene

GeneLoc Exon Structure for
SEBOX
ECgene alternative splicing isoforms for
SEBOX

Expression for SEBOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEBOX Gene

mRNA expression in normal human tissues for SEBOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SEBOX Gene:

SEBOX

SOURCE GeneReport for Unigene cluster for SEBOX Gene:

Hs.728714

Evidence on tissue expression from TISSUES for SEBOX Gene

  • Liver(4.8)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with SEBOX: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEBOX Gene

Orthologs for SEBOX Gene

This gene was present in the common ancestor of mammals.

Orthologs for SEBOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEBOX 32
  • 97.96 (n)
dog
(Canis familiaris)
Mammalia SEBOX 32
  • 83.95 (n)
cow
(Bos Taurus)
Mammalia SEBOX 32
  • 82.3 (n)
mouse
(Mus musculus)
Mammalia Sebox 17 32
  • 75 (n)
rat
(Rattus norvegicus)
Mammalia Sebox 32
  • 74.51 (n)
Species where no ortholog for SEBOX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEBOX Gene

ENSEMBL:
Gene Tree for SEBOX (if available)
TreeFam:
Gene Tree for SEBOX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEBOX: view image

Paralogs for SEBOX Gene

(3) SIMAP similar genes for SEBOX Gene using alignment to 1 proteins:

  • SEBOX_HUMAN
genes like me logo Genes that share paralogs with SEBOX: view

Variants for SEBOX Gene

Sequence variations from dbSNP and Humsavar for SEBOX Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000063356 -- 28,364,109(-) G/C downstream_transcript_variant
rs1000664298 -- 28,365,300(-) G/A/T upstream_transcript_variant
rs1000732250 -- 28,366,554(-) C/G upstream_transcript_variant
rs1001202406 -- 28,365,581(-) C/T upstream_transcript_variant
rs1001896316 -- 28,365,968(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SEBOX Gene

Variant ID Type Subtype PubMed ID
nsv1056839 CNV gain 25217958
nsv519388 CNV loss 19592680
nsv574653 CNV gain 21841781

Variation tolerance for SEBOX Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEBOX Gene

Human Gene Mutation Database (HGMD)
SEBOX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEBOX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEBOX Gene

Disorders for SEBOX Gene

Additional Disease Information for SEBOX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SEBOX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEBOX Gene

Publications for SEBOX Gene

  1. Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos. (PMID: 10922053) Cinquanta M … Nirenberg M (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 56
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  3. Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. (PMID: 25080503) Kwan JS … Kung AW (Human molecular genetics 2014) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L … McKnight A (Retrovirology 2011) 3 56

Products for SEBOX Gene

Sources for SEBOX Gene