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Aliases for SEBOX Gene

Aliases for SEBOX Gene

  • SEBOX Homeobox 2 3 5
  • Skin-, Embryo-, Brain- And Oocyte-Specific Homeobox 3 4
  • Homeobox OG-9 3 4
  • OG9X 3 4
  • Homeobox Protein SEBOX 3
  • OG-9 3
  • OG9 3

External Ids for SEBOX Gene

Previous GeneCards Identifiers for SEBOX Gene

  • GC17M023716
  • GC17M026691
  • GC17M028367
  • GC17M028456
  • GC17M028537
  • GC17M028624
  • GC17M028709
  • GC17M028805
  • GC17M028910

Summaries for SEBOX Gene

Entrez Gene Summary for SEBOX Gene

  • Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SEBOX Gene

SEBOX (SEBOX Homeobox) is a Protein Coding gene. An important paralog of this gene is PROP1.

UniProtKB/Swiss-Prot for SEBOX Gene

  • Probable transcription factor involved in the control of specification of mesoderm and endoderm.

Additional gene information for SEBOX Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEBOX Gene

Genomics for SEBOX Gene

GeneHancer (GH) Regulatory Elements for SEBOX Gene

Promoters and enhancers for SEBOX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I027950 Enhancer 0.5 FANTOM5 ENCODE 14 +413.3 413332 2.2 ZNF623 SEBOX NOS2 LINC01992 LYRM9 GC17M027891
GH17I028500 Enhancer 0.9 FANTOM5 ENCODE 1.8 -135.9 -135886 0.4 BACH1 MAX EBF1 ZIC2 RELA FOXK2 POLR2A ZNF207 ZNF687 NR2F1 UNC119 PIGS SPAG5-AS1 SGK494 SLC46A1 KIAA0100 FOXN1 SPAG5 SEBOX TMEM97
GH17I028391 Enhancer 0.4 FANTOM5 3.3 -26.6 -26558 0.2 L3MBTL2 SEBOX SARM1 FOXN1 FAM222B GC17M029117 ENSG00000279532
GH17I028777 Enhancer 0.3 FANTOM5 1.5 -412.7 -412658 0.3 ZNF362 SEBOX RPL31P58 ENSG00000265840 FAM222B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEBOX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEBOX gene promoter:

Genomic Locations for SEBOX Gene

Genomic Locations for SEBOX Gene
977 bases
Minus strand

Genomic View for SEBOX Gene

Genes around SEBOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEBOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEBOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEBOX Gene

Proteins for SEBOX Gene

  • Protein details for SEBOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein SEBOX
    Protein Accession:

    Protein attributes for SEBOX Gene

    216 amino acids
    Molecular mass:
    22879 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG14458.1; Type=Frameshift; Positions=9; Evidence={ECO:0000305}; Sequence=EAW51081.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SEBOX Gene

Post-translational modifications for SEBOX Gene

No Post-translational modifications

Other Protein References for SEBOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEBOX Gene

Domains & Families for SEBOX Gene

Gene Families for SEBOX Gene

Protein Domains for SEBOX Gene

Suggested Antigen Peptide Sequences for SEBOX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the paired homeobox family.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with SEBOX: view

Function for SEBOX Gene

Molecular function for SEBOX Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in the control of specification of mesoderm and endoderm.

Gene Ontology (GO) - Molecular Function for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with SEBOX: view

Phenotypes for SEBOX Gene

MGI mutant phenotypes for SEBOX:
inferred from 1 alleles
GenomeRNAi human phenotypes for SEBOX:
genes like me logo Genes that share phenotypes with SEBOX: view

Animal Models for SEBOX Gene

MGI Knock Outs for SEBOX:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SEBOX Gene

Localization for SEBOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEBOX Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEBOX gene
Compartment Confidence
extracellular 3
nucleus 3
lysosome 1

Gene Ontology (GO) - Cellular Components for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SEBOX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEBOX Gene

Pathways & Interactions for SEBOX Gene

SuperPathways for SEBOX Gene

No Data Available

Interacting Proteins for SEBOX Gene

Selected Interacting proteins: Q9HB31-SEBOX_HUMAN for SEBOX Gene via IID

Gene Ontology (GO) - Biological Process for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
GO:0009792 embryo development ending in birth or egg hatching IEA --
genes like me logo Genes that share ontologies with SEBOX: view

No data available for Pathways by source and SIGNOR curated interactions for SEBOX Gene

Drugs & Compounds for SEBOX Gene

No Compound Related Data Available

Transcripts for SEBOX Gene

mRNA/cDNA for SEBOX Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEBOX Gene

No ASD Table

Relevant External Links for SEBOX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEBOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEBOX Gene

mRNA expression in normal human tissues for SEBOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SEBOX Gene:


SOURCE GeneReport for Unigene cluster for SEBOX Gene:


Evidence on tissue expression from TISSUES for SEBOX Gene

  • Liver(4.8)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with SEBOX: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEBOX Gene

Orthologs for SEBOX Gene

This gene was present in the common ancestor of mammals.

Orthologs for SEBOX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEBOX 33
  • 97.96 (n)
(Canis familiaris)
Mammalia SEBOX 33
  • 83.95 (n)
(Bos Taurus)
Mammalia SEBOX 33
  • 82.3 (n)
(Mus musculus)
Mammalia Sebox 33 16
  • 75 (n)
(Rattus norvegicus)
Mammalia Sebox 33
  • 74.51 (n)
Species where no ortholog for SEBOX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEBOX Gene

Gene Tree for SEBOX (if available)
Gene Tree for SEBOX (if available)

Paralogs for SEBOX Gene

Paralogs for SEBOX Gene

(3) SIMAP similar genes for SEBOX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SEBOX: view

Variants for SEBOX Gene

Sequence variations from dbSNP and Humsavar for SEBOX Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000063356 -- 28,364,109(-) G/C downstream_transcript_variant
rs1000664298 -- 28,365,300(-) G/A/T upstream_transcript_variant
rs1000732250 -- 28,366,554(-) C/G upstream_transcript_variant
rs1001202406 -- 28,365,581(-) C/T upstream_transcript_variant
rs1001896316 -- 28,365,968(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SEBOX Gene

Variant ID Type Subtype PubMed ID
nsv1056839 CNV gain 25217958
nsv519388 CNV loss 19592680
nsv574653 CNV gain 21841781

Variation tolerance for SEBOX Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEBOX Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEBOX Gene

Disorders for SEBOX Gene

Additional Disease Information for SEBOX

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SEBOX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEBOX Gene

Publications for SEBOX Gene

  1. Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos. (PMID: 10922053) Cinquanta M … Nirenberg M (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. (PMID: 25080503) Kwan JS … Kung AW (Human molecular genetics 2014) 3 58
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L … McKnight A (Retrovirology 2011) 3 58
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 58

Products for SEBOX Gene

Sources for SEBOX Gene

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