Aliases for SDSL Gene

Aliases for SDSL Gene

  • Serine Dehydratase Like 2 3 5
  • Serine Dehydratase-Like 2 3 4
  • L-Serine Dehydratase/L-Threonine Deaminase 3 4
  • L-Threonine Dehydratase 3 4
  • Serine Dehydratase 2 3 4
  • L-Serine Deaminase 3 4
  • SDS-RS1 2 3
  • SDH 2 3 4
  • CSDH 2 3
  • TDH 3 4
  • Serine Dehydratase Related Sequence 1 3
  • EC 4
  • EC 4
  • SDSL 5

External Ids for SDSL Gene

Previous GeneCards Identifiers for SDSL Gene

  • GC12P112273
  • GC12P112322
  • GC12P113860
  • GC12P110871

Summaries for SDSL Gene

GeneCards Summary for SDSL Gene

SDSL (Serine Dehydratase Like) is a Protein Coding gene. Diseases associated with SDSL include Subdural Empyema and Brain Compression. Among its related pathways are threonine degradation and Sulfur amino acid metabolism. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and L-threonine ammonia-lyase activity. An important paralog of this gene is SDS.

UniProtKB/Swiss-Prot Summary for SDSL Gene

Additional gene information for SDSL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SDSL Gene

Genomics for SDSL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SDSL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J113421 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 619.7 +0.2 205 2.4 PRDM10 ZNF629 REST LEF1 IKZF1 JUND LARP7 DDX20 PRDM1 ZIC2 SDSL HSALNG0094158 RBM19 PLBD2 SLC8B1 SDS
GH12J113420 Enhancer 0.3 FANTOM5 624.6 -1.6 -1619 0.1 FOXA1 SDSL HSALNG0094158 PLBD2 SLC8B1 SDS lnc-SDSL-1
GH12J113356 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 20.9 -63.7 -63659 4 SP1 HNRNPL PRDM10 ZNF629 TFE3 ZNF512 LEF1 IKZF1 ZNF692 RCOR2 PLBD2 SLC8B1 LOC105369989 lnc-SDS-1 RBM19 SDSL DDX54 RITA1 ENSG00000201208 RPL6
GH12J113270 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19.2 -150.2 -150227 2.3 CEBPG GATAD2A REST TFE3 IKZF1 JUND SP1 CEBPA CEBPB EGR1 SDSL RASAL1 RITA1 SLC8B1 RBM19 OAS2 OAS3 OAS1 PLBD2 SDS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SDSL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SDSL

Top Transcription factor binding sites by QIAGEN in the SDSL gene promoter:
  • ATF
  • ATF-2
  • c-Jun
  • ITF-2
  • MAZR
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta
  • TBP

Genomic Locations for SDSL Gene

Genomic Locations for SDSL Gene
16,013 bases
Plus strand
16,040 bases
Plus strand

Genomic View for SDSL Gene

Genes around SDSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDSL Gene

Proteins for SDSL Gene

  • Protein details for SDSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine dehydratase-like
    Protein Accession:

    Protein attributes for SDSL Gene

    329 amino acids
    Molecular mass:
    34674 Da
    Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SDSL Gene

neXtProt entry for SDSL Gene

Post-translational modifications for SDSL Gene

  • Ubiquitination at Lys227
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SDSL Gene

Domains & Families for SDSL Gene

Gene Families for SDSL Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SDSL Gene

  • Serine/threonine dehydratase, pyridoxal-phosphate attachment site
  • Pyridoxal-5'-phosphate-dependent enzyme, beta family

Suggested Antigen Peptide Sequences for SDSL Gene

GenScript: Design optimal peptide antigens:
  • Serine dehydratase 2 (SDSL_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serine/threonine dehydratase family.
  • Belongs to the serine/threonine dehydratase family.
genes like me logo Genes that share domains with SDSL: view

Function for SDSL Gene

Molecular function for SDSL Gene

UniProtKB/Swiss-Prot Function:
Has low serine dehydratase and threonine dehydratase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169, ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=; Evidence={ECO:0000269|PubMed:18342636};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-threonine = 2-oxobutanoate + NH4(+); Xref=Rhea:RHEA:22108, ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:57926; EC=; Evidence={ECO:0000269|PubMed:18342636};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 mM for serine; KM=7 mM for threonine;

Enzyme Numbers (IUBMB) for SDSL Gene

Phenotypes From GWAS Catalog for SDSL Gene

Gene Ontology (GO) - Molecular Function for SDSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003941 L-serine ammonia-lyase activity IBA --
GO:0004794 L-threonine ammonia-lyase activity IBA 21873635
GO:0016829 lyase activity IEA --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with SDSL: view
genes like me logo Genes that share phenotypes with SDSL: view

Animal Models for SDSL Gene

MGI Knock Outs for SDSL:
  • Sdsl Sdsl<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for SDSL Gene

miRTarBase miRNAs that target SDSL

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SDSL

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SDSL Gene

Localization for SDSL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDSL gene
Compartment Confidence
cytosol 5
plasma membrane 2
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SDSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SDSL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SDSL Gene

Pathways & Interactions for SDSL Gene

genes like me logo Genes that share pathways with SDSL: view

Gene Ontology (GO) - Biological Process for SDSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process IEA --
GO:0006565 L-serine catabolic process IBA --
GO:0006566 threonine metabolic process IBA 21873635
GO:0006567 threonine catabolic process IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SDSL: view

No data available for SIGNOR curated interactions for SDSL Gene

Drugs & Compounds for SDSL Gene

(6) Drugs for SDSL Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxal Phosphate Approved, Investigational Nutra Target, cofactor 16
Ammonia Approved Pharma 0
Pyruvic acid Approved, Investigational Nutra 0
Threonine Approved Nutra 35
2-Ketobutyric acid Experimental Pharma 0
genes like me logo Genes that share compounds with SDSL: view

Transcripts for SDSL Gene

mRNA/cDNA for SDSL Gene

3 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SDSL

Alternative Splicing Database (ASD) splice patterns (SP) for SDSL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP6: -

Relevant External Links for SDSL Gene

GeneLoc Exon Structure for

Expression for SDSL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SDSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDSL Gene

This gene is overexpressed in Liver (x11.6).

Protein differential expression in normal tissues from HIPED for SDSL Gene

This gene is overexpressed in Liver (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SDSL Gene

Protein tissue co-expression partners for SDSL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SDSL

SOURCE GeneReport for Unigene cluster for SDSL Gene:


Evidence on tissue expression from TISSUES for SDSL Gene

  • Liver(4.4)
  • Lung(4.3)
  • Nervous system(2.7)
  • Skin(2.4)
  • Muscle(2.3)
  • Blood(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with SDSL: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDSL Gene

Orthologs for SDSL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDSL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SDSL 30 31
  • 99.19 (n)
(Bos Taurus)
Mammalia SDSL 30 31
  • 84.65 (n)
(Canis familiaris)
Mammalia SDSL 30 31
  • 84.45 (n)
(Rattus norvegicus)
Mammalia Sdsl 30
  • 81.19 (n)
(Mus musculus)
Mammalia Sdsl 30 17 31
  • 81.14 (n)
(Monodelphis domestica)
Mammalia SDSL 31
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SDSL 31
  • 61 (a)
(Gallus gallus)
Aves SDSL 30 31
  • 69.93 (n)
(Anolis carolinensis)
Reptilia SDSL 31
  • 64 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sdsl 30
  • 63.85 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68790 30
(Danio rerio)
Actinopterygii LOC563642 30
  • 58.84 (n)
  • 54 (a)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5154 30
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHA1 30 31 33
  • 44.3 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00440g 30
  • 42.65 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
Species where no ortholog for SDSL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SDSL Gene

Gene Tree for SDSL (if available)
Gene Tree for SDSL (if available)
Evolutionary constrained regions (ECRs) for SDSL: view image

Paralogs for SDSL Gene

Paralogs for SDSL Gene

(1) SIMAP similar genes for SDSL Gene using alignment to 5 proteins:

  • F8VZ97_HUMAN
genes like me logo Genes that share paralogs with SDSL: view

Variants for SDSL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SDSL Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
788888 Likely Benign: not provided 113,436,762(+) GC/G FRAMESHIFT_VARIANT
rs200347609 Not Provided: not provided 113,434,139(+) G/A NONSENSE

Additional dbSNP identifiers (rs#s) for SDSL Gene

Structural Variations from Database of Genomic Variants (DGV) for SDSL Gene

Variant ID Type Subtype PubMed ID
esv3630792 CNV gain 21293372
esv3892265 CNV gain 25118596
nsv1118505 CNV duplication 24896259
nsv519540 CNV gain+loss 19592680

Variation tolerance for SDSL Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SDSL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDSL Gene

Disorders for SDSL Gene

MalaCards: The human disease database

(17) MalaCards diseases for SDSL Gene - From: DISEASES

Disorder Aliases PubMed IDs
subdural empyema
  • subdural abscess
brain compression
  • compression of brain
intracranial hypotension
superior semicircular canal dehiscence
  • canal dehiscence syndrome
suppression amblyopia
  • strabismic amblyopia
- elite association - COSMIC cancer census association via MalaCards
Search SDSL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SDSL

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SDSL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDSL Gene

Publications for SDSL Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  2. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PMID: 18342636) Yamada T … Takusagawa F (Biochimica et biophysica acta 2008) 3 4
  3. Enzymatic and biochemical properties of a novel human serine dehydratase isoform. (PMID: 16580895) Ogawa H … Kobayashi M (Biochimica et biophysica acta 2006) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for SDSL Gene

Sources for SDSL Gene