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Aliases for SDR39U1 Gene

Aliases for SDR39U1 Gene

  • Short Chain Dehydrogenase/Reductase Family 39U Member 1 2 3 5
  • C14orf124 3 4
  • HCDI 3 4
  • Short-Chain Dehydrogenase/Reductase Family 39U Member 1 4
  • Chromosome 14 Open Reading Frame 124 2
  • Epimerase Family Protein SDR39U1 3
  • EC 1.1.1.- 4

External Ids for SDR39U1 Gene

Previous HGNC Symbols for SDR39U1 Gene

  • C14orf124

Previous GeneCards Identifiers for SDR39U1 Gene

  • GC14M023979
  • GC14M024908
  • GC14M005023

Summaries for SDR39U1 Gene

Entrez Gene Summary for SDR39U1 Gene

  • This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) superfamily, which includes both classical and extended types. The encoded protein represents an extended type, with similarity to epimerases. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for SDR39U1 Gene

SDR39U1 (Short Chain Dehydrogenase/Reductase Family 39U Member 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and coenzyme binding.

UniProtKB/Swiss-Prot for SDR39U1 Gene

  • Putative NADP-dependent oxidoreductase.

Additional gene information for SDR39U1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDR39U1 Gene

Genomics for SDR39U1 Gene

GeneHancer (GH) Regulatory Elements for SDR39U1 Gene

Promoters and enhancers for SDR39U1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I024441 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 589.6 +0.3 339 2.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 SDR39U1 GC14P024445 PIR37686 LOC101927045 MDP1 ENSG00000258744 CBLN3 KHNYN
GH14I024442 Enhancer 0.4 ENCODE dbSUPER 550.8 +1.9 1850 0.1 LOC101927045 GC14P024445 SDR39U1 PIR37686 CBLN3 KHNYN
GH14I024422 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 48.6 +15.2 15160 10.3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 NFYC CBLN3 KHNYN SDR39U1 NYNRIN MDP1 NGDN NFATC4 ENSG00000259321 TINF2 ADCY4
GH14I023953 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 40.6 +488.8 488801 2 HDGF SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 DHRS4 ACIN1 SDR39U1 NGDN RNA5SP383 RNF31 KHNYN TSSK4 DHRS4-AS1 PABPN1
GH14I024187 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 21.9 +254.6 254595 2.6 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 IPO4 NGDN RNA5SP383 KHNYN RNF31 NFATC4 LOC102724814 ENSG00000259321 SDR39U1 SLC22A17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SDR39U1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SDR39U1 gene promoter:

Genomic Locations for SDR39U1 Gene

Genomic Locations for SDR39U1 Gene
chr14:24,439,766-24,442,905
(GRCh38/hg38)
Size:
3,140 bases
Orientation:
Minus strand
chr14:24,908,972-24,912,111
(GRCh37/hg19)

Genomic View for SDR39U1 Gene

Genes around SDR39U1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDR39U1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDR39U1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDR39U1 Gene

Proteins for SDR39U1 Gene

  • Protein details for SDR39U1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRG7-D39U1_HUMAN
    Recommended name:
    Epimerase family protein SDR39U1
    Protein Accession:
    Q9NRG7
    Secondary Accessions:
    • Q6ZW71
    • Q9BVQ3

    Protein attributes for SDR39U1 Gene

    Size:
    319 amino acids
    Molecular mass:
    34748 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Despite its name, it shares more sequence similarity with the sugar epimerase family than with the short-chain dehydrogenases/reductases (SDR) family.

    Three dimensional structures from OCA and Proteopedia for SDR39U1 Gene

    Alternative splice isoforms for SDR39U1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDR39U1 Gene

Post-translational modifications for SDR39U1 Gene

No data available for DME Specific Peptides for SDR39U1 Gene

Domains & Families for SDR39U1 Gene

Gene Families for SDR39U1 Gene

Protein Domains for SDR39U1 Gene

Suggested Antigen Peptide Sequences for SDR39U1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRG7

UniProtKB/Swiss-Prot:

D39U1_HUMAN :
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
Family:
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
genes like me logo Genes that share domains with SDR39U1: view

Function for SDR39U1 Gene

Molecular function for SDR39U1 Gene

UniProtKB/Swiss-Prot Function:
Putative NADP-dependent oxidoreductase.

Enzyme Numbers (IUBMB) for SDR39U1 Gene

Phenotypes From GWAS Catalog for SDR39U1 Gene

Gene Ontology (GO) - Molecular Function for SDR39U1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with SDR39U1: view
genes like me logo Genes that share phenotypes with SDR39U1: view

Animal Model Products

miRNA for SDR39U1 Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDR39U1 Gene

Localization for SDR39U1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDR39U1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SDR39U1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with SDR39U1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SDR39U1 Gene

Pathways & Interactions for SDR39U1 Gene

SuperPathways for SDR39U1 Gene

No Data Available

Interacting Proteins for SDR39U1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000382327%0d%0a9606.ENSP00000262507%0d%0a9606.ENSP00000319851%0d%0a
Selected Interacting proteins: Q9NRG7-D39U1_HUMAN ENSP00000382327 for SDR39U1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SDR39U1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SDR39U1: view

No data available for Pathways by source and SIGNOR curated interactions for SDR39U1 Gene

Drugs & Compounds for SDR39U1 Gene

No Compound Related Data Available

Transcripts for SDR39U1 Gene

Unigene Clusters for SDR39U1 Gene

Short chain dehydrogenase/reductase family 39U, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDR39U1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: -
SP10: - - - - - - - - -
SP11: - - -
SP12: - - -
SP13:
SP14: -

Relevant External Links for SDR39U1 Gene

GeneLoc Exon Structure for
SDR39U1
ECgene alternative splicing isoforms for
SDR39U1

Expression for SDR39U1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDR39U1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SDR39U1 Gene

This gene is overexpressed in Brain (14.3) and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SDR39U1 Gene



Protein tissue co-expression partners for SDR39U1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SDR39U1 Gene:

SDR39U1

SOURCE GeneReport for Unigene cluster for SDR39U1 Gene:

Hs.643552

mRNA Expression by UniProt/SwissProt for SDR39U1 Gene:

Q9NRG7-D39U1_HUMAN
Tissue specificity: Expressed in adrenal gland.

Evidence on tissue expression from TISSUES for SDR39U1 Gene

  • Nervous system(4.6)
  • Adrenal gland(4.3)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with SDR39U1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDR39U1 Gene

Orthologs for SDR39U1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SDR39U1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDR39U1 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia SDR39U1 33 34
  • 89.87 (n)
cow
(Bos Taurus)
Mammalia SDR39U1 33 34
  • 88.96 (n)
rat
(Rattus norvegicus)
Mammalia Sdr39u1 33
  • 86.06 (n)
mouse
(Mus musculus)
Mammalia Sdr39u1 33 16 34
  • 85.5 (n)
oppossum
(Monodelphis domestica)
Mammalia SDR39U1 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDR39U1 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdr39u1 33
  • 59.93 (n)
zebrafish
(Danio rerio)
Actinopterygii sdr39u1 33 34
  • 59.05 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000649 33
  • 53.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8768 33 34
  • 49.42 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SULA 33
  • 48.94 (n)
rice
(Oryza sativa)
Liliopsida Os02g0834700 33
  • 47.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5445 34
  • 47 (a)
OneToOne
Species where no ortholog for SDR39U1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDR39U1 Gene

ENSEMBL:
Gene Tree for SDR39U1 (if available)
TreeFam:
Gene Tree for SDR39U1 (if available)

Paralogs for SDR39U1 Gene

No data available for Paralogs for SDR39U1 Gene

Variants for SDR39U1 Gene

Sequence variations from dbSNP and Humsavar for SDR39U1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001158420 -- 24,443,539(-) C/T upstream_transcript_variant
rs1001346952 -- 24,439,385(-) C/T downstream_transcript_variant
rs1001776218 -- 24,439,794(-) A/G 3_prime_UTR_variant
rs1002455742 -- 24,443,269(-) T/C upstream_transcript_variant
rs1002558024 -- 24,441,206(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SDR39U1 Gene

Variant ID Type Subtype PubMed ID
nsv564061 CNV loss 21841781
nsv482171 CNV loss 20164927
dgv1854n100 CNV gain 25217958

Variation tolerance for SDR39U1 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SDR39U1 Gene

Human Gene Mutation Database (HGMD)
SDR39U1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDR39U1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDR39U1 Gene

Disorders for SDR39U1 Gene

Additional Disease Information for SDR39U1

No disorders were found for SDR39U1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDR39U1 Gene

Publications for SDR39U1 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58

Products for SDR39U1 Gene

Sources for SDR39U1 Gene

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