Aliases for SDR16C5 Gene
External Ids for SDR16C5 Gene
Previous GeneCards Identifiers for SDR16C5 Gene
This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for SDR16C5 Gene
SDR16C5 (Short Chain Dehydrogenase/Reductase Family 16C Member 5) is a Protein Coding gene. Diseases associated with SDR16C5 include Siberian Tick Typhus and Psoriasis. Among its related pathways are Drug metabolism - cytochrome P450 and Signaling by Retinoic Acid. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and retinol dehydrogenase activity. An important paralog of this gene is RDH10.
UniProtKB/Swiss-Prot Summary for SDR16C5 Gene
Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH.