The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing ... See more...

Aliases for SDK1 Gene

Aliases for SDK1 Gene

  • Sidekick Cell Adhesion Molecule 1 2 3 5
  • Protein Sidekick-1 3 4
  • Sidekick Homolog 1, Cell Adhesion Molecule (Chicken) 2
  • Sidekick Homolog 1, Cell Adhesion Molecule 3
  • Sidekick Homolog 1 (Chicken) 2

External Ids for SDK1 Gene

Previous GeneCards Identifiers for SDK1 Gene

  • GC07P003695
  • GC07P003712
  • GC07P003085
  • GC07P003114

Summaries for SDK1 Gene

Entrez Gene Summary for SDK1 Gene

  • The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

GeneCards Summary for SDK1 Gene

SDK1 (Sidekick Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with SDK1 include Brachydactyly, Type A1, B and Brachydactyly, Type A1. An important paralog of this gene is SDK2.

UniProtKB/Swiss-Prot Summary for SDK1 Gene

  • Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.

Additional gene information for SDK1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SDK1 Gene

Genomics for SDK1 Gene

GeneHancer (GH) Regulatory Elements for SDK1 Gene

Promoters and enhancers for SDK1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J003300 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 519.6 +0.6 603 3.1 HNRNPK EP300 CTCF ZIC2 ZBTB26 MYC CHD1 CTBP1 SKI NFYB SDK1 ENSG00000236708 LOC105375132 L13304-031 L13715-024
GH07J004129 Promoter 0.6 EPDnew 500 +828.4 828414 0.1 RCOR1 GATA2 HNRNPL SDK1 ENSG00000283991 LOC105375131 piR-41306-239
GH07J003302 Enhancer 0.4 CraniofacialAtlas 500.7 -1.2 -1183 0.2 ZNF263 SP7 ZNF629 SREBF1 SDK1 ENSG00000236708 LOC105375132 piR-48759-280 L13304-031 L13715-024
GH07J003299 Enhancer 0.2 Ensembl 500.7 -1.6 -1551 0.2 SDK1 ENSG00000236708 LOC105375132 piR-48759-280 L13304-031 L13715-024
GH07J003267 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -32.8 -32848 1.6 ZSCAN5C TCF12 FOS ZNF639 POLR2A FOSL2 KLF8 SIN3A ZNF189 KLF17 SDK1 ENSG00000236708 hsa-miR-5096-074 FJ601684-415 LOC105375132 L13304-031 L13715-024
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SDK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SDK1

Top Transcription factor binding sites by QIAGEN in the SDK1 gene promoter:
  • E47
  • Hand1
  • Lmo2
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • POU6F1 (c2)
  • RORalpha2
  • TBP

Genomic Locations for SDK1 Gene

Genomic Locations for SDK1 Gene
967,749 bases
Plus strand
967,553 bases
Plus strand

Genomic View for SDK1 Gene

Genes around SDK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDK1 Gene

Proteins for SDK1 Gene

  • Protein details for SDK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein sidekick-1
    Protein Accession:
    Secondary Accessions:
    • Q8TEN9
    • Q8TEP5
    • Q96N44

    Protein attributes for SDK1 Gene

    2213 amino acids
    Molecular mass:
    242112 Da
    Quaternary structure:
    • Homodimer; mediates homophilic interactions to promote cell adhesion.
    • Dysregulation of this protein may play an important role in podocyte dysfunction in HIV-associated nephropathy.

    Alternative splice isoforms for SDK1 Gene


neXtProt entry for SDK1 Gene

Post-translational modifications for SDK1 Gene

  • Glycosylation at Asn271, Asn301, Asn550, Asn563, Asn572, Asn655, Asn679, Asn782, Asn821, Asn882, Asn1015, Asn1024, Asn1282, Asn1333, Asn1654, Asn1748, Asn1767, Asn1819, and Asn1893
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SDK1 Gene

Domains & Families for SDK1 Gene

Gene Families for SDK1 Gene

Protein Domains for SDK1 Gene

  • Immunoglobulin C-2 type

Suggested Antigen Peptide Sequences for SDK1 Gene

GenScript: Design optimal peptide antigens:
  • Protein sidekick-1 (SDK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Ig-like C2-type domains 1 and 2 mediate homophilic interactions.
  • Belongs to the sidekick family.
  • Ig-like C2-type domains 1 and 2 mediate homophilic interactions.
  • Belongs to the sidekick family.
genes like me logo Genes that share domains with SDK1: view

Function for SDK1 Gene

Molecular function for SDK1 Gene

UniProtKB/Swiss-Prot Function:
Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.

Phenotypes From GWAS Catalog for SDK1 Gene

Gene Ontology (GO) - Molecular Function for SDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with SDK1: view
genes like me logo Genes that share phenotypes with SDK1: view

Animal Models for SDK1 Gene

MGI Knock Outs for SDK1:
  • Sdk1 Sdk1<tm1.1(cre/ERT2)Jrs>

Animal Model Products

  • Taconic Biosciences Mouse Models for SDK1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SDK1 Gene

Localization for SDK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDK1 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDK1 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IBA,ISS --
genes like me logo Genes that share ontologies with SDK1: view

Pathways & Interactions for SDK1 Gene

PathCards logo

SuperPathways for SDK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA,ISS --
GO:0007416 synapse assembly IBA,ISS --
GO:0010842 retina layer formation IBA,ISS --
GO:0045216 cell-cell junction organization TAS --
genes like me logo Genes that share ontologies with SDK1: view

No data available for Pathways by source and SIGNOR curated interactions for SDK1 Gene

Drugs & Compounds for SDK1 Gene

No Compound Related Data Available

Transcripts for SDK1 Gene

mRNA/cDNA for SDK1 Gene

9 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a ·
SP1: - -
SP2: - - -
SP3: -

ExUns: 47b ^ 48
SP3: -

Relevant External Links for SDK1 Gene

GeneLoc Exon Structure for

Expression for SDK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SDK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDK1 Gene

This gene is overexpressed in Artery - Tibial (x4.7) and Pancreas (x4.4).

Protein differential expression in normal tissues from HIPED for SDK1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (29.6), Serum (12.4), Spleen (6.6), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SDK1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SDK1

SOURCE GeneReport for Unigene cluster for SDK1 Gene:


mRNA Expression by UniProt/SwissProt for SDK1 Gene:

Tissue specificity: Up-regulated in glomeruli in HIV-associated nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells (PubMed:15213259).

Evidence on tissue expression from TISSUES for SDK1 Gene

  • Nervous system(4.4)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with SDK1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDK1 Gene

Orthologs for SDK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SDK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SDK1 31 30
  • 98.78 (n)
(Canis familiaris)
Mammalia SDK1 31 30
  • 86.67 (n)
(Monodelphis domestica)
Mammalia SDK1 31
  • 86 (a)
(Mus musculus)
Mammalia Sdk1 17 31 30
  • 84.91 (n)
(Bos Taurus)
Mammalia SDK1 31 30
  • 84.66 (n)
(Rattus norvegicus)
Mammalia Sdk1 30
  • 84.24 (n)
(Ornithorhynchus anatinus)
Mammalia SDK1 31
  • 83 (a)
(Gallus gallus)
Aves SDK1 31 30
  • 76.73 (n)
(Anolis carolinensis)
Reptilia SDK1 31
  • 78 (a)
(Danio rerio)
Actinopterygii sdk1a 31 30
  • 68.25 (n)
sdk1b 31
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dscam4 31
  • 18 (a)
Dscam2 31
  • 18 (a)
Dscam3 31
  • 17 (a)
Dscam 31
  • 17 (a)
(Caenorhabditis elegans)
Secernentea rig-4 31
  • 26 (a)
Species where no ortholog for SDK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SDK1 Gene

Gene Tree for SDK1 (if available)
Gene Tree for SDK1 (if available)
Evolutionary constrained regions (ECRs) for SDK1: view image

Paralogs for SDK1 Gene

(7) SIMAP similar genes for SDK1 Gene using alignment to 3 proteins:

  • F8W6X9_HUMAN
  • H7C255_HUMAN Pseudogenes for SDK1 Gene

genes like me logo Genes that share paralogs with SDK1: view

Variants for SDK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SDK1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
716874 Benign: not provided 3,967,428(+) A/G MISSENSE_VARIANT
716875 Benign: not provided 4,077,065(+) G/A SYNONYMOUS_VARIANT
716938 Benign: not provided 4,077,044(+) C/T SYNONYMOUS_VARIANT
725338 Likely Benign: not provided 4,241,905(+) C/T SYNONYMOUS_VARIANT
770182 Benign: not provided 4,051,651(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SDK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SDK1 Gene

Variant ID Type Subtype PubMed ID
dgv1087n67 CNV gain 20364138
dgv1088n67 CNV gain 20364138
dgv1089n67 CNV loss 20364138
dgv11149n54 CNV gain+loss 21841781
dgv11150n54 CNV loss 21841781
dgv11151n54 CNV loss 21841781
dgv11152n54 CNV loss 21841781
dgv11153n54 CNV loss 21841781
dgv11154n54 CNV loss 21841781
dgv11155n54 CNV loss 21841781
dgv11156n54 CNV loss 21841781
dgv11157n54 CNV loss 21841781
dgv11158n54 CNV loss 21841781
dgv11159n54 CNV loss 21841781
dgv11160n54 CNV loss 21841781
dgv11161n54 CNV loss 21841781
dgv11162n54 CNV loss 21841781
dgv11163n54 CNV loss 21841781
dgv11164n54 CNV loss 21841781
dgv11165n54 CNV gain 21841781
dgv1180e199 CNV deletion 23128226
dgv1181e199 CNV deletion 23128226
dgv1243e214 CNV loss 21293372
dgv1244e214 CNV loss 21293372
dgv1245e214 CNV gain 21293372
dgv1860e212 CNV loss 25503493
dgv1861e212 CNV loss 25503493
dgv1862e212 CNV loss 25503493
dgv233n111 CNV duplication 26073780
dgv3477n106 CNV deletion 24896259
dgv3478n106 CNV deletion 24896259
dgv3479n106 CNV deletion 24896259
dgv3480n106 CNV deletion 24896259
dgv3742e59 CNV duplication 20981092
dgv6222n100 CNV loss 25217958
dgv6223n100 CNV loss 25217958
dgv6224n100 CNV loss 25217958
dgv6225n100 CNV loss 25217958
dgv6226n100 CNV loss 25217958
dgv6227n100 CNV loss 25217958
dgv6228n100 CNV gain 25217958
dgv6229n100 CNV loss 25217958
dgv6230n100 CNV loss 25217958
dgv6231n100 CNV gain 25217958
dgv6232n100 CNV gain 25217958
dgv797n27 CNV gain 19166990
esv1002214 CNV deletion 20482838
esv1005213 CNV loss 20482838
esv1006873 CNV insertion 20482838
esv1008693 CNV insertion 20482838
esv1201708 CNV deletion 17803354
esv1551786 CNV insertion 17803354
esv1559042 CNV deletion 17803354
esv1562452 CNV insertion 17803354
esv1730974 CNV insertion 17803354
esv1756780 CNV insertion 17803354
esv2004915 CNV deletion 18987734
esv2154358 CNV deletion 18987734
esv22195 CNV gain 19812545
esv22623 CNV loss 19812545
esv22966 CNV loss 19812545
esv2303183 CNV deletion 18987734
esv2320457 CNV deletion 18987734
esv2323495 CNV deletion 18987734
esv2430419 CNV deletion 19546169
esv25458 CNV loss 19812545
esv2567177 CNV deletion 19546169
esv2589929 CNV deletion 19546169
esv26074 CNV loss 19812545
esv26185 CNV gain 19812545
esv2652301 CNV deletion 19546169
esv2657323 CNV deletion 23128226
esv2662079 CNV deletion 23128226
esv2664910 CNV deletion 23128226
esv2666607 CNV deletion 23128226
esv2668470 CNV deletion 23128226
esv2674504 CNV deletion 23128226
esv2674935 CNV deletion 23128226
esv2675206 CNV deletion 23128226
esv2677474 CNV deletion 23128226
esv26943 CNV gain 19812545
esv27140 CNV loss 19812545
esv2733873 CNV deletion 23290073
esv2733874 CNV deletion 23290073
esv2733875 CNV deletion 23290073
esv2733876 CNV deletion 23290073
esv2733877 CNV deletion 23290073
esv2733878 CNV deletion 23290073
esv2733879 CNV deletion 23290073
esv2733880 CNV deletion 23290073
esv2733881 CNV deletion 23290073
esv2733882 CNV deletion 23290073
esv2733884 CNV deletion 23290073
esv2733885 CNV deletion 23290073
esv2733886 CNV deletion 23290073
esv2733887 CNV deletion 23290073
esv2733888 CNV deletion 23290073
esv2733889 CNV deletion 23290073
esv2733890 CNV deletion 23290073
esv2733891 CNV deletion 23290073
esv2733892 CNV deletion 23290073
esv2733893 CNV deletion 23290073
esv2733895 CNV deletion 23290073
esv2733896 CNV deletion 23290073
esv2733897 CNV deletion 23290073
esv2733898 CNV deletion 23290073
esv2733899 CNV deletion 23290073
esv2733900 CNV deletion 23290073
esv2742996 CNV deletion 23290073
esv2759500 CNV gain+loss 17122850
esv2759501 CNV loss 17122850
esv2761095 CNV loss 21179565
esv2762640 CNV loss 21179565
esv2764026 CNV gain+loss 21179565
esv2764033 CNV gain 21179565
esv28341 CNV loss 19812545
esv29028 CNV loss 19812545
esv29410 CNV gain 19812545
esv3281718 CNV deletion 24192839
esv3307918 CNV mobile element insertion 20981092
esv3310436 CNV novel sequence insertion 20981092
esv3335885 CNV insertion 20981092
esv3337658 CNV insertion 20981092
esv3374889 CNV insertion 20981092
esv3378432 CNV insertion 20981092
esv3402640 CNV insertion 20981092
esv3413426 CNV duplication 20981092
esv3445954 CNV duplication 20981092
esv3448434 CNV insertion 20981092
esv3449029 CNV insertion 20981092
esv3541068 CNV deletion 23714750
esv3541069 CNV deletion 23714750
esv3541070 CNV deletion 23714750
esv3541071 CNV deletion 23714750
esv3541072 CNV deletion 23714750
esv3541073 CNV deletion 23714750
esv3541074 CNV deletion 23714750
esv3541076 CNV deletion 23714750
esv3541079 CNV deletion 23714750
esv3571566 CNV loss 25503493
esv3571567 CNV loss 25503493
esv3571568 CNV loss 25503493
esv3571571 CNV loss 25503493
esv3571573 CNV loss 25503493
esv3571579 CNV loss 25503493
esv3571580 CNV loss 25503493
esv3576284 CNV gain 25503493
esv3611869 CNV gain 21293372
esv3611871 CNV loss 21293372
esv3611872 CNV gain 21293372
esv3611873 CNV loss 21293372
esv3611874 CNV loss 21293372
esv3611875 CNV loss 21293372
esv3611876 CNV loss 21293372
esv3611879 CNV gain 21293372
esv3611881 CNV loss 21293372
esv3611882 CNV gain 21293372
esv3611885 CNV gain 21293372
esv3611886 CNV loss 21293372
esv3611887 CNV gain 21293372
esv3611888 CNV gain 21293372
esv3611889 CNV loss 21293372
esv3611890 CNV loss 21293372
esv3611891 CNV loss 21293372
esv3611892 CNV gain 21293372
esv3611893 CNV loss 21293372
esv3611894 CNV gain 21293372
esv3611895 CNV loss 21293372
esv3611896 CNV loss 21293372
esv3611897 CNV loss 21293372
esv3611898 CNV loss 21293372
esv3611900 CNV loss 21293372
esv3611901 CNV loss 21293372
esv3611902 CNV gain 21293372
esv3611904 CNV loss 21293372
esv3611905 CNV loss 21293372
esv3611906 CNV gain 21293372
esv3611907 CNV loss 21293372
esv3611908 CNV loss 21293372
esv3611909 CNV gain 21293372
esv3611910 CNV loss 21293372
esv3611913 CNV loss 21293372
esv3891012 CNV loss 25118596
esv3891013 CNV loss 25118596
esv3891014 CNV gain 25118596
esv3891016 CNV loss 25118596
esv3891017 CNV loss 25118596
esv3891018 CNV loss 25118596
esv3891019 CNV loss 25118596
esv3891020 CNV gain 25118596
esv4375 CNV loss 18987735
esv989356 CNV insertion 20482838
nsv1015296 CNV loss 25217958
nsv1016930 CNV gain 25217958
nsv1018462 CNV loss 25217958
nsv1019190 CNV loss 25217958
nsv1019305 CNV gain 25217958
nsv1024445 CNV loss 25217958
nsv1025623 CNV loss 25217958
nsv1025850 CNV gain 25217958
nsv1026295 CNV loss 25217958
nsv1028585 CNV loss 25217958
nsv1029296 CNV gain 25217958
nsv1030157 CNV gain 25217958
nsv1030363 CNV loss 25217958
nsv1032892 CNV gain 25217958
nsv1033720 CNV loss 25217958
nsv1073629 CNV deletion 25765185
nsv1073630 CNV deletion 25765185
nsv1073680 CNV deletion 25765185
nsv1074063 CNV deletion 25765185
nsv1075003 CNV deletion 25765185
nsv1111333 CNV tandem duplication 24896259
nsv1112452 CNV deletion 24896259
nsv1112453 CNV deletion 24896259
nsv1124163 CNV deletion 24896259
nsv1133020 CNV deletion 24896259
nsv1137570 CNV deletion 24896259
nsv1140737 CNV deletion 24896259
nsv1140738 CNV deletion 24896259
nsv1140739 CNV deletion 24896259
nsv1141526 CNV duplication 24896259
nsv1147812 CNV deletion 26484159
nsv365802 CNV insertion 16902084
nsv366234 CNV deletion 16902084
nsv366864 CNV deletion 16902084
nsv437530 CNV loss 16327808
nsv437980 CNV loss 16468122
nsv442025 CNV loss 18776908
nsv442026 CNV loss 18776908
nsv464264 CNV loss 19166990
nsv464268 CNV gain 19166990
nsv464269 CNV loss 19166990
nsv464270 CNV loss 19166990
nsv464271 CNV loss 19166990
nsv464273 CNV loss 19166990
nsv464279 CNV gain 19166990
nsv471260 CNV gain 18288195
nsv477126 CNV novel sequence insertion 20440878
nsv499704 CNV gain 21111241
nsv509187 CNV insertion 20534489
nsv510063 OTHER sequence alteration 20534489
nsv511943 CNV loss 21212237
nsv515665 CNV loss 19592680
nsv517001 CNV loss 19592680
nsv517279 CNV loss 19592680
nsv517675 CNV gain+loss 19592680
nsv518299 CNV loss 19592680
nsv518377 CNV loss 19592680
nsv518625 CNV loss 19592680
nsv519027 CNV loss 19592680
nsv519151 CNV loss 19592680
nsv519403 CNV loss 19592680
nsv520034 CNV loss 19592680
nsv521103 CNV gain 19592680
nsv523815 CNV gain 19592680
nsv524581 CNV loss 19592680
nsv525399 CNV loss 19592680
nsv527624 CNV gain 19592680
nsv528715 CNV loss 19592680
nsv5621 CNV insertion 18451855
nsv5622 CNV insertion 18451855
nsv5623 CNV deletion 18451855
nsv605880 CNV loss 21841781
nsv605887 CNV loss 21841781
nsv605889 CNV loss 21841781
nsv605890 CNV gain 21841781
nsv605892 CNV loss 21841781
nsv605893 CNV loss 21841781
nsv605894 CNV gain 21841781
nsv605897 CNV loss 21841781
nsv605899 CNV loss 21841781
nsv605900 CNV loss 21841781
nsv605901 CNV loss 21841781
nsv605902 CNV loss 21841781
nsv605903 CNV loss 21841781
nsv605904 CNV loss 21841781
nsv605907 CNV loss 21841781
nsv605908 CNV loss 21841781
nsv605909 CNV loss 21841781
nsv605924 CNV loss 21841781
nsv605928 CNV loss 21841781
nsv605934 CNV loss 21841781
nsv605935 CNV loss 21841781
nsv605936 CNV loss 21841781
nsv605939 CNV gain 21841781
nsv605944 CNV loss 21841781
nsv605947 CNV loss 21841781
nsv605948 CNV loss 21841781
nsv605950 CNV loss 21841781
nsv8031 CNV gain+loss 18304495
nsv8032 CNV gain 18304495
nsv818473 CNV gain 17921354
nsv818474 CNV loss 17921354
nsv819413 CNV gain 19587683
nsv820619 CNV deletion 20802225
nsv820996 CNV deletion 20802225
nsv821269 CNV deletion 20802225
nsv823988 CNV loss 20364138
nsv823989 CNV loss 20364138
nsv830888 CNV gain 17160897
nsv950795 CNV deletion 24416366
nsv950796 CNV deletion 24416366
nsv956974 CNV deletion 24416366
nsv956997 CNV deletion 24416366
nsv966747 CNV duplication 23825009
nsv981826 CNV duplication 23825009

Variation tolerance for SDK1 Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.09; 84.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SDK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDK1 Gene

Disorders for SDK1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SDK1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
brachydactyly, type a1, b
  • bda1b
brachydactyly, type a1
  • bda1
- elite association - COSMIC cancer census association via MalaCards
Search SDK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SDK1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SDK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDK1 Gene

Publications for SDK1 Gene

  1. Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. (PMID: 15213259) Kaufman L … Klotman PE (Journal of the American Society of Nephrology : JASN 2004) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41 54
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 41 54
  5. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 41 54

Products for SDK1 Gene

Sources for SDK1 Gene