Aliases for SDHB Gene
- Succinate Dehydrogenase Complex Iron Sulfur Subunit B 2 3 5
- Iron-Sulfur Subunit Of Complex II 2 3 4
- Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial 3 4
- Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) 2 3
- SDH1 3 4
- SDH 3 4
- Succinate Dehydrogenase Complex Subunit B, Iron Sulfur (Ip) 2
External Ids for SDHB Gene
Previous HGNC Symbols for SDHB Gene
Previous GeneCards Identifiers for SDHB Gene
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for SDHB Gene
SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) is a Protein Coding gene. Diseases associated with SDHB include Paragangliomas 4 and Paraganglioma And Gastric Stromal Sarcoma. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 4 iron, 4 sulfur cluster binding.
UniProtKB/Swiss-Prot Summary for SDHB Gene
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).