Aliases for SDHAF4 Gene
External Ids for SDHAF4 Gene
Previous HGNC Symbols for SDHAF4 Gene
GeneCards Summary for SDHAF4 Gene
SDHAF4 (Succinate Dehydrogenase Complex Assembly Factor 4) is a Protein Coding gene.
UniProtKB/Swiss-Prot Summary for SDHAF4 Gene
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity).