Aliases for SDF2L1 Gene

Aliases for SDF2L1 Gene

  • Stromal Cell Derived Factor 2 Like 1 2 3 5
  • PWP1-Interacting Protein 8 2 3 4
  • Stromal Cell-Derived Factor 2-Like Protein 1 3 4
  • Dihydropyrimidinase-Like 2 2 3
  • SDF2-Like Protein 1 3 4
  • Stromal Cell-Derived Factor 2-Like 1 2
  • SDF2-Like 1 3

External Ids for SDF2L1 Gene

Previous GeneCards Identifiers for SDF2L1 Gene

  • GC22P018695
  • GC22P020320
  • GC22P020321
  • GC22P021996
  • GC22P004954
  • GC22P021741
  • GC22P021810
  • GC22P022111
  • GC22P022152
  • GC22P021827
  • GC22P021858
  • GC22P021874
  • GC22P021911
  • GC22P021946
  • GC22P021976
  • GC22P022020
  • GC22P022069

Summaries for SDF2L1 Gene

GeneCards Summary for SDF2L1 Gene

SDF2L1 (Stromal Cell Derived Factor 2 Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chaperone binding and misfolded protein binding. An important paralog of this gene is SDF2.

Additional gene information for SDF2L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SDF2L1 Gene

Genomics for SDF2L1 Gene

GeneHancer (GH) Regulatory Elements for SDF2L1 Gene

Promoters and enhancers for SDF2L1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SDF2L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SDF2L1 gene promoter:
  • aMEF-2
  • Brachyury
  • E47
  • GATA-1
  • MEF-2A
  • Pax-5
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • YY1

Genomic Locations for SDF2L1 Gene

Genomic Locations for SDF2L1 Gene
chr22:21,642,253-21,644,299
(GRCh38/hg38)
Size:
2,047 bases
Orientation:
Plus strand
chr22:21,996,542-21,998,588
(GRCh37/hg19)
Size:
2,047 bases
Orientation:
Plus strand

Genomic View for SDF2L1 Gene

Genes around SDF2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDF2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDF2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDF2L1 Gene

Proteins for SDF2L1 Gene

  • Protein details for SDF2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCN8-SDF2L_HUMAN
    Recommended name:
    Stromal cell-derived factor 2-like protein 1
    Protein Accession:
    Q9HCN8
    Secondary Accessions:
    • A2RUD3
    • Q9BRI5

    Protein attributes for SDF2L1 Gene

    Size:
    221 amino acids
    Molecular mass:
    23598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SDF2L1 Gene

Post-translational modifications for SDF2L1 Gene

  • Glycosylation at Ser211
  • Modification sites at PhosphoSitePlus

Other Protein References for SDF2L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDF2L1 Gene

Domains & Families for SDF2L1 Gene

Gene Families for SDF2L1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SDF2L1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SDF2L1 Gene

GenScript: Design optimal peptide antigens:
  • PWP1-interacting protein 8 (SDF2L_HUMAN)
genes like me logo Genes that share domains with SDF2L1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SDF2L1 Gene

Function for SDF2L1 Gene

Molecular function for SDF2L1 Gene

GENATLAS Biochemistry:
stromal cell-derived factor 2-like 1

Phenotypes From GWAS Catalog for SDF2L1 Gene

Gene Ontology (GO) - Molecular Function for SDF2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA 21873635
GO:0051087 chaperone binding IEA --
GO:0051117 ATPase binding IEA --
GO:0051787 misfolded protein binding IEA --
genes like me logo Genes that share ontologies with SDF2L1: view
genes like me logo Genes that share phenotypes with SDF2L1: view

Animal Model Products

CRISPR Products

miRNA for SDF2L1 Gene

miRTarBase miRNAs that target SDF2L1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDF2L1 Gene

Localization for SDF2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDF2L1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDF2L1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3

Gene Ontology (GO) - Cellular Components for SDF2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0034663 endoplasmic reticulum chaperone complex IEA --
genes like me logo Genes that share ontologies with SDF2L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SDF2L1 Gene

Pathways & Interactions for SDF2L1 Gene

PathCards logo

SuperPathways for SDF2L1 Gene

No Data Available

SIGNOR curated interactions for SDF2L1 Gene

Activates:

Gene Ontology (GO) - Biological Process for SDF2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IEA --
GO:0035269 protein O-linked mannosylation IBA 21873635
GO:0042981 regulation of apoptotic process IEA --
GO:0071218 cellular response to misfolded protein IEA --
GO:0071712 ER-associated misfolded protein catabolic process IEA --
genes like me logo Genes that share ontologies with SDF2L1: view

No data available for Pathways by source for SDF2L1 Gene

Drugs & Compounds for SDF2L1 Gene

No Compound Related Data Available

Transcripts for SDF2L1 Gene

mRNA/cDNA for SDF2L1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(144) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDF2L1 Gene

No ASD Table

Relevant External Links for SDF2L1 Gene

GeneLoc Exon Structure for
SDF2L1
ECgene alternative splicing isoforms for
SDF2L1

Expression for SDF2L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDF2L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDF2L1 Gene

This gene is overexpressed in Liver (x5.5).

Protein differential expression in normal tissues from HIPED for SDF2L1 Gene

This gene is overexpressed in Lavage (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SDF2L1 Gene



Protein tissue co-expression partners for SDF2L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SDF2L1 Gene:

SDF2L1

SOURCE GeneReport for Unigene cluster for SDF2L1 Gene:

Hs.303116

mRNA Expression by UniProt/SwissProt for SDF2L1 Gene:

Q9HCN8-SDF2L_HUMAN
Tissue specificity: Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen, prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle.

Evidence on tissue expression from TISSUES for SDF2L1 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SDF2L1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SDF2L1 Gene

Orthologs for SDF2L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SDF2L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDF2L1 33 32
  • 99.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SDF2L1 33 32
  • 90.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SDF2L1 33 32
  • 87.93 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdf2l1 32
  • 86.77 (n)
mouse
(Mus musculus)
Mammalia Sdf2l1 17 33 32
  • 85.37 (n)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130b 33
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDF2L1 33
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDF2L1 33 32
  • 72.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDF2L1 33
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732749 32
  • 65.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5458 32
zebrafish
(Danio rerio)
Actinopterygii sdf2l1 33 32
  • 65.28 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11999 33 34
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R12E2.13 33 34
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11079 33
  • 46 (a)
OneToMany
Species where no ortholog for SDF2L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDF2L1 Gene

ENSEMBL:
Gene Tree for SDF2L1 (if available)
TreeFam:
Gene Tree for SDF2L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SDF2L1: view image

Paralogs for SDF2L1 Gene

Paralogs for SDF2L1 Gene

(1) SIMAP similar genes for SDF2L1 Gene using alignment to 1 proteins:

  • SDF2L_HUMAN
genes like me logo Genes that share paralogs with SDF2L1: view

Variants for SDF2L1 Gene

Sequence variations from dbSNP and Humsavar for SDF2L1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000056378 -- 21,640,882(+) G/T upstream_transcript_variant
rs1001585621 -- 21,642,173(+) A/T upstream_transcript_variant
rs1001630409 -- 21,642,182(+) C/T upstream_transcript_variant
rs1001637826 -- 21,642,313(+) A/C 5_prime_UTR_variant
rs1001725339 -- 21,642,355(+) G/A/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SDF2L1 Gene

Variant ID Type Subtype PubMed ID
nsv516806 CNV loss 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for SDF2L1 Gene

Gene Damage Index Score: 2.91; 48.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SDF2L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDF2L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDF2L1 Gene

Disorders for SDF2L1 Gene

Additional Disease Information for SDF2L1

No disorders were found for SDF2L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDF2L1 Gene

Publications for SDF2L1 Gene

  1. Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family. (PMID: 11162531) Fukuda S … Kamiya K (Biochemical and biophysical research communications 2001) 2 3 4 23 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 56
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 56

Products for SDF2L1 Gene

Sources for SDF2L1 Gene