Aliases for SDE2 Gene
External Ids for SDE2 Gene
Previous HGNC Symbols for SDE2 Gene
Previous GeneCards Identifiers for SDE2 Gene
GeneCards Summary for SDE2 Gene
SDE2 (SDE2 Telomere Maintenance Homolog) is a Protein Coding gene. An important paralog of this gene is SF3A3.
UniProtKB/Swiss-Prot Summary for SDE2 Gene
Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression (PubMed:27906959).