Aliases for SDCCAG8 Gene
External Ids for SDCCAG8 Gene
Previous GeneCards Identifiers for SDCCAG8 Gene
This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]
GeneCards Summary for SDCCAG8 Gene
SDCCAG8 (Serologically Defined Colon Cancer Antigen 8) is a Protein Coding gene. Diseases associated with SDCCAG8 include Bardet-Biedl Syndrome 16 and Senior-Loken Syndrome 7. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic.
UniProtKB/Swiss-Prot Summary for SDCCAG8 Gene
Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062).