The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and ... See more...

Aliases for SDCBP Gene

Aliases for SDCBP Gene

  • Syndecan Binding Protein 2 3 5
  • Syntenin-1 2 3 4
  • MDA-9 2 3 4
  • SYCL 2 3 4
  • Pro-TGF-Alpha Cytoplasmic Domain-Interacting Protein 18 3 4
  • Syndecan-Binding Protein 1 3 4
  • Scaffold Protein Pbp1 3 4
  • TACIP18 3 4
  • MDA9 3 4
  • Melanoma Differentiation Associated Protein-9 3
  • Melanoma Differentiation-Associated Protein 9 4
  • Syndecan Binding Protein (Syntenin) 3
  • Syntenin 2
  • SDCBP 5
  • ST1 3

External Ids for SDCBP Gene

Previous GeneCards Identifiers for SDCBP Gene

  • GC08P059405
  • GC08P059188
  • GC08P059515
  • GC08P059628
  • GC08P054952

Summaries for SDCBP Gene

Entrez Gene Summary for SDCBP Gene

  • The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]

GeneCards Summary for SDCBP Gene

SDCBP (Syndecan Binding Protein) is a Protein Coding gene. Diseases associated with SDCBP include Neurofibromatosis, Type Ii and Pontiac Fever. Among its related pathways are EPH-Ephrin signaling and Syndecan-4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is SDCBP2.

UniProtKB/Swiss-Prot Summary for SDCBP Gene

  • Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

Gene Wiki entry for SDCBP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SDCBP Gene

Genomics for SDCBP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SDCBP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J058552 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 260.8 +2.4 2356 6.2 SP1 ZNF207 NCOR1 ZNF600 IKZF1 JUND ZNF580 POLR2A ATF3 BRCA1 SDCBP HSALNG0065565 MN298500 RF00017-6515 NSMAF
GH08J058396 Enhancer 1 FANTOM5 ENCODE dbSUPER 16.7 -155.7 -155666 2.4 CEBPA SPI1 MYC MAX HNF4A ZNF48 REST CEBPG L3MBTL2 SP1 lnc-UBXN2B-1 SDCBP UBXN2B lnc-CYP7A1-9 FAM110B
GH08J058593 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 10.9 +42.6 42621 4 NCOR1 JUND BCL11A CEBPB ZNF592 TRIM22 BHLHE40 MNT ARNT MAFF lnc-CYP7A1-6 SDCBP TRE-CTC5-1 RF00017-6515 NSMAF
GH08J058410 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 5.6 -141.0 -141023 2.6 BCLAF1 ZNF207 MYC POLR2A CEBPA YY1 MXD4 CTCF CEBPB SMAD5 UBXN2B lnc-CYP7A1-9 SDCBP MN298499 CYP7A1
GH08J058128 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 8.7 -423.4 -423423 3.8 CEBPA CEBPB FEZF1 TEAD3 ZNF843 NFE2 JUNB CEBPG TRIM28 HLF SDCBP RPL26P26 HSALNG0065549 FAM110B lnc-FAM110B-1 UBXN2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SDCBP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SDCBP

Top Transcription factor binding sites by QIAGEN in the SDCBP gene promoter:
  • aMEF-2
  • C/EBPalpha
  • MEF-2
  • MEF-2A
  • p53
  • Sox9

Genomic Locations for SDCBP Gene

Latest Assembly
chr8:58,552,924-58,582,860
(GRCh38/hg38)
Size:
29,937 bases
Orientation:
Plus strand

Previous Assembly
chr8:59,465,820-59,495,417
(GRCh37/hg19 by Entrez Gene)
Size:
29,598 bases
Orientation:
Plus strand

chr8:59,465,483-59,495,419
(GRCh37/hg19 by Ensembl)
Size:
29,937 bases
Orientation:
Plus strand

Genomic View for SDCBP Gene

Genes around SDCBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDCBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDCBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDCBP Gene

Proteins for SDCBP Gene

  • Protein details for SDCBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00560-SDCB1_HUMAN
    Recommended name:
    Syntenin-1
    Protein Accession:
    O00560
    Secondary Accessions:
    • B2R5Q7
    • B4DUH3
    • B7ZLN2
    • O00173
    • O43391
    • Q14CP2

    Protein attributes for SDCBP Gene

    Size:
    298 amino acids
    Molecular mass:
    32444 Da
    Quaternary structure:
    • Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA. Interacts with NFASC and PTPRJ (By similarity). Interacts with SDCBP2 (PubMed:11152476). Interacts with PDCD6IP (PubMed:22660413). Forms a complex with PDCD6IP and SDC2 (PubMed:22660413). Interacts (via C-terminus) with TGFBR1 (PubMed:25893292). Binds to FZD7; this interaction is increased by inositol trisphosphate (IP3) (PubMed:27386966). Interacts with SMO (By similarity).

    Three dimensional structures from OCA and Proteopedia for SDCBP Gene

    Alternative splice isoforms for SDCBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDCBP Gene

Post-translational modifications for SDCBP Gene

No data available for DME Specific Peptides for SDCBP Gene

Domains & Families for SDCBP Gene

Gene Families for SDCBP Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SDCBP Gene

InterPro:
Blocks:
  • PDZ/DHR/GLGF domain

Suggested Antigen Peptide Sequences for SDCBP Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92571, highly similar to Homo sapiens syndecan binding protein (syntenin) (SDCBP), mRNA (B2R5Q7_HUMAN)
  • cDNA FLJ55055, moderately similar to Syntenin-1 (B4DHN5_HUMAN)
  • Syndecan-binding protein 1 (SDCB1_HUMAN)
genes like me logo Genes that share domains with SDCBP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SDCBP Gene

Function for SDCBP Gene

Molecular function for SDCBP Gene

UniProtKB/Swiss-Prot Function:
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma in melanoma cells.

Phenotypes From GWAS Catalog for SDCBP Gene

Gene Ontology (GO) - Molecular Function for SDCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005109 frizzled binding IPI 18256285
GO:0005137 interleukin-5 receptor binding IEA,ISS 11498591
GO:0005515 protein binding IEA,IPI 12842047
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 27386966
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with SDCBP: view
genes like me logo Genes that share phenotypes with SDCBP: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SDCBP

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDCBP Gene

Localization for SDCBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDCBP Gene

Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane. Peripheral membrane protein. Endoplasmic reticulum membrane. Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Secreted, extracellular exosome. Membrane raft. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966). {ECO:0000269 PubMed:11179419, ECO:0000269 PubMed:12643545, ECO:0000269 PubMed:17081065, ECO:0000269 PubMed:27386966}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDCBP gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
lysosome 4
mitochondrion 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SDCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 16502470
GO:0005634 nucleus NAS 11179419
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 18256285
genes like me logo Genes that share ontologies with SDCBP: view

Pathways & Interactions for SDCBP Gene

genes like me logo Genes that share pathways with SDCBP: view

SIGNOR curated interactions for SDCBP Gene

Activates:

Gene Ontology (GO) - Biological Process for SDCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002091 negative regulation of receptor internalization IMP 25893292
GO:0006612 protein targeting to membrane NAS 10230395
GO:0006930 substrate-dependent cell migration, cell extension NAS 12037664
GO:0007265 Ras protein signal transduction IEA --
GO:0007268 chemical synaptic transmission IEA,NAS 9883737
genes like me logo Genes that share ontologies with SDCBP: view

Drugs & Compounds for SDCBP Gene

(1) Drugs for SDCBP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SDCBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SDCBP: view

Transcripts for SDCBP Gene

mRNA/cDNA for SDCBP Gene

9 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SDCBP

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SDCBP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^ 10 ^ 11a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - -
SP11: - -
SP12:
SP13: -
SP14:

ExUns: 11b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SDCBP Gene

GeneLoc Exon Structure for
SDCBP

Expression for SDCBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SDCBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDCBP Gene

This gene is overexpressed in Whole Blood (x9.5).

Protein differential expression in normal tissues from HIPED for SDCBP Gene

This gene is overexpressed in Urine (13.7), Amniocyte (9.4), and Milk (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SDCBP Gene



Protein tissue co-expression partners for SDCBP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SDCBP

SOURCE GeneReport for Unigene cluster for SDCBP Gene:

Hs.200804

mRNA Expression by UniProt/SwissProt for SDCBP Gene:

O00560-SDCB1_HUMAN
Tissue specificity: Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.

Evidence on tissue expression from TISSUES for SDCBP Gene

  • Nervous system(5)
  • Blood(4.9)
  • Liver(4.8)
  • Intestine(4.6)
  • Skin(4.4)
  • Lung(4.2)
  • Kidney(4)
  • Stomach(3.2)
  • Pancreas(3.2)
  • Spleen(2.9)
  • Lymph node(2.8)
  • Heart(2.7)
  • Bone marrow(2.7)
  • Muscle(2.6)
  • Adrenal gland(2.4)
  • Eye(2.4)
  • Thyroid gland(2.4)
  • Bone(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with SDCBP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SDCBP Gene

Orthologs for SDCBP Gene

This gene was present in the common ancestor of animals.

Orthologs for SDCBP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SDCBP 29 30
  • 99.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 95 (a)
OneToMany
SDCBP 29
  • 93.06 (n)
-- 30
  • 92 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Sdcbp 29 16 30
  • 87.25 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sdcbp 29
  • 86.35 (n)
Cow
(Bos Taurus)
Mammalia SDCBP 29 30
  • 86.24 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SDCBP 30
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SDCBP 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SDCBP 29 30
  • 80.27 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SDCBP 30
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sdcbp 29
  • 74.58 (n)
Str.6014 29
African clawed frog
(Xenopus laevis)
Amphibia sdcbp-prov 29
Zebrafish
(Danio rerio)
Actinopterygii sdcbp 29 30
  • 64.05 (n)
OneToOne
Dr.1778 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009569 29
  • 53.27 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6469 30
  • 56 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5544 29
Species where no ortholog for SDCBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SDCBP Gene

ENSEMBL:
Gene Tree for SDCBP (if available)
TreeFam:
Gene Tree for SDCBP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SDCBP: view image
Alliance of Genome Resources:
Additional Orthologs for SDCBP

Paralogs for SDCBP Gene

Paralogs for SDCBP Gene

(1) SIMAP similar genes for SDCBP Gene using alignment to 4 proteins:

  • SDCB1_HUMAN
  • B4DHN5_HUMAN
  • E9PBU7_HUMAN
  • G5EA09_HUMAN

Pseudogenes.org Pseudogenes for SDCBP Gene

genes like me logo Genes that share paralogs with SDCBP: view

Variants for SDCBP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SDCBP Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs1127509 -- p.Asn69Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SDCBP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SDCBP Gene

Variant ID Type Subtype PubMed ID
esv3307770 CNV mobile element insertion 20981092
esv3346499 CNV insertion 20981092
esv3617340 CNV gain 21293372
esv3891402 CNV gain 25118596
nsv1031537 CNV gain 25217958
nsv1075140 CNV deletion 25765185
nsv397168 CNV deletion 16902084
nsv831325 CNV gain 17160897
nsv981944 CNV duplication 23825009

Variation tolerance for SDCBP Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SDCBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDCBP
Leiden Open Variation Database (LOVD)
SDCBP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDCBP Gene

Disorders for SDCBP Gene

MalaCards: The human disease database

(7) MalaCards diseases for SDCBP Gene - From: COP and GCD

Disorder Aliases PubMed IDs
neurofibromatosis, type ii
  • nf2
pontiac fever
melanoma
  • malignant melanoma
deafness, autosomal dominant 33
  • dfna33
brain glioma
  • lower grade glioma
- elite association - COSMIC cancer census association via MalaCards
Search SDCBP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SDCBP

genes like me logo Genes that share disorders with SDCBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDCBP Gene

Publications for SDCBP Gene

  1. The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography. (PMID: 15081807) Kang BS … Derewenda ZS (Journal of molecular biology 2004) 3 4 22
  2. PDZ tandem of human syntenin: crystal structure and functional properties. (PMID: 12679023) Kang BS … Derewenda ZS (Structure (London, England : 1993) 2003) 3 4 22
  3. Schwannomin isoform-1 interacts with syntenin via PDZ domains. (PMID: 11432873) Jannatipour M … Rouleau GA (The Journal of biological chemistry 2001) 3 4 22
  4. Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments. (PMID: 11179419) Zimmermann P … David G (Molecular biology of the cell 2001) 3 4 22
  5. Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. (PMID: 11498591) Geijsen N … Coffer PJ (Science (New York, N.Y.) 2001) 3 4 22

Products for SDCBP Gene

Sources for SDCBP Gene