Aliases for SDC1 Gene
External Ids for SDC1 Gene
Previous HGNC Symbols for SDC1 Gene
Previous GeneCards Identifiers for SDC1 Gene
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for SDC1 Gene
SDC1 (Syndecan 1) is a Protein Coding gene. Diseases associated with SDC1 include Monoclonal Gammopathy Of Uncertain Significance and Granulomatous Endometritis. Among its related pathways are Microglia Activation During Neuroinflammation: Overview and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding. An important paralog of this gene is SDC3.
UniProtKB/Swiss-Prot Summary for SDC1 Gene
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).