Aliases for SCYL2 Gene
External Ids for SCYL2 Gene
Previous GeneCards Identifiers for SCYL2 Gene
The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for SCYL2 Gene
SCYL2 (SCY1 Like Pseudokinase 2) is a Protein Coding gene. Diseases associated with SCYL2 include Cataract 8, Multiple Types. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and binding.
UniProtKB/Swiss-Prot for SCYL2 Gene
Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.