Aliases for SCYGR8 Gene

Aliases for SCYGR8 Gene

  • Small Cysteine And Glycine Repeat Containing 8 2 3 5
  • Keratin Associated Protein 28-8 2 3
  • KRTAP28-8 3 4
  • Small Cysteine And Glycine Repeat-Containing Protein 8 4
  • Keratin-Associated Protein 28-8 4

External Ids for SCYGR8 Gene

Summaries for SCYGR8 Gene

GeneCards Summary for SCYGR8 Gene

SCYGR8 (Small Cysteine And Glycine Repeat Containing 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for SCYGR8 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for SCYGR8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCYGR8 Gene

Genomics for SCYGR8 Gene

GeneHancer (GH) Regulatory Elements for SCYGR8 Gene

Promoters and enhancers for SCYGR8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J227759 Enhancer 1 Ensembl ENCODE 0.4 +15.4 15383 4.4 TCF12 NCOR1 TCF7 ZNF623 TEAD1 U2AF2 CREB1 FOXA2 CEBPB FOS RNA5SP121 SCYGR8
GH02J227757 Enhancer 0.6 Ensembl ENCODE 0.4 +11.4 11393 0.5 RAD21 CHD7 EP300 CTCF KDM1A RNA5SP121 SCYGR8
GH02J227758 Enhancer 0.4 Ensembl 0.4 +12.0 11956 0.4 CHD7 EP300 KDM1A RNA5SP121 SCYGR8
GH02J227738 Enhancer 0.3 ENCODE 0.4 -6.4 -6400 1 NR2F6 piR-55809-021 CCL20 SCYGR8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCYGR8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SCYGR8 Gene

Genomic Locations for SCYGR8 Gene
chr2:227,745,845-227,746,681
(GRCh38/hg38)
Size:
837 bases
Orientation:
Plus strand

Genomic View for SCYGR8 Gene

Genes around SCYGR8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCYGR8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCYGR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for SCYGR8 Gene

Proteins for SCYGR8 Gene

  • Protein details for SCYGR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A286YFG1-SCGR8_HUMAN
    Recommended name:
    Small cysteine and glycine repeat-containing protein 8
    Protein Accession:
    A0A286YFG1

    Protein attributes for SCYGR8 Gene

    Size:
    108 amino acids
    Molecular mass:
    10123 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Human have a similar number of genes as other primates despite the relative hairlessness of humans.

neXtProt entry for SCYGR8 Gene

Post-translational modifications for SCYGR8 Gene

No Post-translational modifications

Other Protein References for SCYGR8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for SCYGR8 Gene

Domains & Families for SCYGR8 Gene

Protein Domains for SCYGR8 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A0A286YFG1

UniProtKB/Swiss-Prot:

SCGR8_HUMAN :
  • Belongs to the KRTAP type 28 family.
Family:
  • Belongs to the KRTAP type 28 family.
genes like me logo Genes that share domains with SCYGR8: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SCYGR8 Gene

Function for SCYGR8 Gene

Molecular function for SCYGR8 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCYGR8 Gene

Localization for SCYGR8 Gene

Gene Ontology (GO) - Cellular Components for SCYGR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with SCYGR8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SCYGR8 Gene

Pathways & Interactions for SCYGR8 Gene

PathCards logo

SuperPathways for SCYGR8 Gene

No Data Available

Interacting Proteins for SCYGR8 Gene

;

Gene Ontology (GO) - Biological Process for SCYGR8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCYGR8 Gene

Drugs & Compounds for SCYGR8 Gene

No Compound Related Data Available

Transcripts for SCYGR8 Gene

mRNA/cDNA for SCYGR8 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SCYGR8 Gene

No ASD Table

Relevant External Links for SCYGR8 Gene

GeneLoc Exon Structure for
SCYGR8

Expression for SCYGR8 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCYGR8 Gene

Orthologs for SCYGR8 Gene

Evolution for SCYGR8 Gene

ENSEMBL:
Gene Tree for SCYGR8 (if available)
TreeFam:
Gene Tree for SCYGR8 (if available)

No data available for Orthologs for SCYGR8 Gene

Paralogs for SCYGR8 Gene

No data available for Paralogs for SCYGR8 Gene

Variants for SCYGR8 Gene

Additional Variant Information for SCYGR8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCYGR8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SCYGR8 Gene

Disorders for SCYGR8 Gene

No disorders were found for SCYGR8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SCYGR8 Gene

Publications for SCYGR8 Gene

  1. Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. (PMID: 18721477) Wu DD … Zhang YP (BMC evolutionary biology 2008) 2 3 4 54
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 54

No data available for Mastermind for SCYGR8 Gene

Products for SCYGR8 Gene

Sources for SCYGR8 Gene