Aliases for SCYGR6 Gene

Aliases for SCYGR6 Gene

  • Small Cysteine And Glycine Repeat Containing 6 2 3 5
  • KRTAP28-6 2 3 4
  • Keratin Associated Protein 28-6 2 3
  • Small Cysteine And Glycine Repeat-Containing Protein 6 4
  • Keratin-Associated Protein 28-6 4
  • SCYGR6 5

External Ids for SCYGR6 Gene

Summaries for SCYGR6 Gene

GeneCards Summary for SCYGR6 Gene

SCYGR6 (Small Cysteine And Glycine Repeat Containing 6) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for SCYGR6 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for SCYGR6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCYGR6 Gene

Genomics for SCYGR6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SCYGR6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J227723 Enhancer 0.4 Ensembl 250.7 +1.7 1656 0.2 FOXA2 SAP130 DMAP1 SCYGR6 SLC19A3
GH02J227724 Enhancer 0.3 Ensembl 250.7 -0.3 -344 0.2 SPI1 SCYGR6 CCL20 SLC19A3 SCYGR7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCYGR6 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for SCYGR6 Gene

Latest Assembly
chr2:227,724,440-227,724,757
(GRCh38/hg38)
Size:
318 bases
Orientation:
Minus strand

Genomic View for SCYGR6 Gene

Genes around SCYGR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCYGR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCYGR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for SCYGR6 Gene

Proteins for SCYGR6 Gene

  • Protein details for SCYGR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A286YF77-SCGR6_HUMAN
    Recommended name:
    Small cysteine and glycine repeat-containing protein 6
    Protein Accession:
    A0A286YF77

    Protein attributes for SCYGR6 Gene

    Size:
    105 amino acids
    Molecular mass:
    9896 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Human have a similar number of genes as other primates despite the relative hairlessness of humans.

neXtProt entry for SCYGR6 Gene

Post-translational modifications for SCYGR6 Gene

No Post-translational modifications

Other Protein References for SCYGR6 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for SCYGR6 Gene

Domains & Families for SCYGR6 Gene

Graphical View of Domain Structure for InterPro Entry

A0A286YF77

UniProtKB/Swiss-Prot:

SCGR6_HUMAN :
  • Belongs to the KRTAP type 28 family.
Family:
  • Belongs to the KRTAP type 28 family.
genes like me logo Genes that share domains with SCYGR6: view

No data available for Gene Families , Protein Domains and Suggested Antigen Peptide Sequences for SCYGR6 Gene

Function for SCYGR6 Gene

Molecular function for SCYGR6 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes From GWAS Catalog for SCYGR6 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCYGR6 Gene

Localization for SCYGR6 Gene

Gene Ontology (GO) - Cellular Components for SCYGR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with SCYGR6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SCYGR6 Gene

Pathways & Interactions for SCYGR6 Gene

PathCards logo

SuperPathways for SCYGR6 Gene

No Data Available

Interacting Proteins for SCYGR6 Gene

Gene Ontology (GO) - Biological Process for SCYGR6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCYGR6 Gene

Drugs & Compounds for SCYGR6 Gene

No Compound Related Data Available

Transcripts for SCYGR6 Gene

mRNA/cDNA for SCYGR6 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SCYGR6 Gene

No ASD Table

Relevant External Links for SCYGR6 Gene

GeneLoc Exon Structure for
SCYGR6

Expression for SCYGR6 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCYGR6 Gene

Orthologs for SCYGR6 Gene

Evolution for SCYGR6 Gene

ENSEMBL:
Gene Tree for SCYGR6 (if available)
TreeFam:
Gene Tree for SCYGR6 (if available)
Alliance of Genome Resources:
Additional Orthologs for SCYGR6

No data available for Orthologs for SCYGR6 Gene

Paralogs for SCYGR6 Gene

No data available for Paralogs for SCYGR6 Gene

Variants for SCYGR6 Gene

Additional Variant Information for SCYGR6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCYGR6
Leiden Open Variation Database (LOVD)
SCYGR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SCYGR6 Gene

Disorders for SCYGR6 Gene

No disorders were found for SCYGR6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SCYGR6 Gene

Publications for SCYGR6 Gene

  1. Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. (PMID: 18721477) Wu DD … Zhang YP (BMC evolutionary biology 2008) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4

No data available for Mastermind for SCYGR6 Gene

Products for SCYGR6 Gene

Sources for SCYGR6 Gene