Aliases for SCYGR5 Gene

Aliases for SCYGR5 Gene

  • Small Cysteine And Glycine Repeat Containing 5 2 3 5
  • KRTAP28-5 2 3 4
  • Keratin Associated Protein 28-5 2 3
  • Small Cysteine And Glycine Repeat-Containing Protein 5 4
  • Keratin-Associated Protein 28-5 4
  • SCYGR5 5

External Ids for SCYGR5 Gene

Summaries for SCYGR5 Gene

GeneCards Summary for SCYGR5 Gene

SCYGR5 (Small Cysteine And Glycine Repeat Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for SCYGR5 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCYGR5 Gene

Genomics for SCYGR5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SCYGR5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J227715 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.2 +51.1 51056 4.7 ATF3 YY1 HOMEZ KLF9 FOXA2 RXRA SAP130 DMAP1 GABPB1 ZBTB33 SLC19A3 lnc-C2orf83-3 lnc-C2orf83-2 SCYGR5
GH02J227658 Enhancer 0.9 Ensembl dbSUPER 0.4 -8.4 -8375 0.6 ZNF654 SSRP1 CTCF REST ZNF592 TRIM22 THAP11 ZNF511 RAD21 SMC3 HSALNG0022759-002 C2orf83 MG828603 SCYGR5 HSALNG0022759-001
GH02J227654 Enhancer 1 Ensembl dbSUPER 0.4 -11.5 -11503 1.8 JUND CEBPA ATF3 YY1 CEBPB HOMEZ EP300 FOXA2 CTBP1 SMAD4 C2orf83 HSALNG0022759-002 MG828603 SCYGR5 HSALNG0022759-001
GH02J227653 Enhancer 1 Ensembl dbSUPER 0.4 -13.3 -13304 1 CEBPA ATF3 YY1 CEBPB ZFP64 HOMEZ FOXA2 MAFF RXRA SAP130 C2orf83 MG828603 HSALNG0022759-002 SCYGR5 HSALNG0022759-001
GH02J227700 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +36.0 36012 4 CEBPA ATF3 JUND YY1 ZNF217 CEBPB FEZF1 ZFP64 EP300 MBD2 HSALNG0022764 CCL20 SLC19A3 lnc-C2orf83-1 lnc-C2orf83-3 SCYGR5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCYGR5 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for SCYGR5 Gene

Latest Assembly
chr2:227,666,804-227,667,061
(GRCh38/hg38)
Size:
258 bases
Orientation:
Plus strand

Genomic View for SCYGR5 Gene

Genes around SCYGR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCYGR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCYGR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for SCYGR5 Gene

Proteins for SCYGR5 Gene

  • Protein details for SCYGR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A286YF46-SCGR5_HUMAN
    Recommended name:
    Small cysteine and glycine repeat-containing protein 5
    Protein Accession:
    A0A286YF46

    Protein attributes for SCYGR5 Gene

    Size:
    85 amino acids
    Molecular mass:
    8201 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Human have a similar number of genes as other primates despite the relative hairlessness of humans.

neXtProt entry for SCYGR5 Gene

Post-translational modifications for SCYGR5 Gene

No Post-translational modifications

Other Protein References for SCYGR5 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for SCYGR5 Gene

Domains & Families for SCYGR5 Gene

Graphical View of Domain Structure for InterPro Entry

A0A286YF46

UniProtKB/Swiss-Prot:

SCGR5_HUMAN :
  • Belongs to the KRTAP type 28 family.
Family:
  • Belongs to the KRTAP type 28 family.
genes like me logo Genes that share domains with SCYGR5: view

No data available for Gene Families , Protein Domains and Suggested Antigen Peptide Sequences for SCYGR5 Gene

Function for SCYGR5 Gene

Molecular function for SCYGR5 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes From GWAS Catalog for SCYGR5 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCYGR5 Gene

Localization for SCYGR5 Gene

Gene Ontology (GO) - Cellular Components for SCYGR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with SCYGR5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SCYGR5 Gene

Pathways & Interactions for SCYGR5 Gene

PathCards logo

SuperPathways for SCYGR5 Gene

No Data Available

Interacting Proteins for SCYGR5 Gene

Gene Ontology (GO) - Biological Process for SCYGR5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCYGR5 Gene

Drugs & Compounds for SCYGR5 Gene

No Compound Related Data Available

Transcripts for SCYGR5 Gene

mRNA/cDNA for SCYGR5 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SCYGR5 Gene

No ASD Table

Relevant External Links for SCYGR5 Gene

GeneLoc Exon Structure for
SCYGR5

Expression for SCYGR5 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCYGR5 Gene

Orthologs for SCYGR5 Gene

Evolution for SCYGR5 Gene

ENSEMBL:
Gene Tree for SCYGR5 (if available)
TreeFam:
Gene Tree for SCYGR5 (if available)
Alliance of Genome Resources:
Additional Orthologs for SCYGR5

No data available for Orthologs for SCYGR5 Gene

Paralogs for SCYGR5 Gene

No data available for Paralogs for SCYGR5 Gene

Variants for SCYGR5 Gene

Additional Variant Information for SCYGR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCYGR5
Leiden Open Variation Database (LOVD)
SCYGR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SCYGR5 Gene

Disorders for SCYGR5 Gene

Additional Disease Information for SCYGR5

Open Targets Platform
Open Targets Platform

No disorders were found for SCYGR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCYGR5 Gene

Publications for SCYGR5 Gene

  1. Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. (PMID: 18721477) Wu DD … Zhang YP (BMC evolutionary biology 2008) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4

No data available for Mastermind for SCYGR5 Gene

Products for SCYGR5 Gene

Sources for SCYGR5 Gene