Aliases for SCYGR4 Gene

Aliases for SCYGR4 Gene

  • Small Cysteine And Glycine Repeat Containing 4 2 3 5
  • KRTAP28-4 2 3 4
  • Keratin Associated Protein 28-4 2 3
  • Small Cysteine And Glycine Repeat-Containing Protein 4 4
  • Keratin-Associated Protein 28-4 4
  • SCYGR4 5

External Ids for SCYGR4 Gene

Summaries for SCYGR4 Gene

GeneCards Summary for SCYGR4 Gene

SCYGR4 (Small Cysteine And Glycine Repeat Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for SCYGR4 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for SCYGR4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCYGR4 Gene

Genomics for SCYGR4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SCYGR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J227616 Enhancer 0.2 Ensembl 250.7 -0.2 -198 1.2 ENSG00000236116 LOC729968 SCYGR3 SCYGR4 HSALNG0022759-001 C2orf83
GH02J227644 Enhancer 0.9 Ensembl 0.3 +27.2 27203 0.4 CEBPA CHD4 FOXA1 ZFP64 HOMEZ THAP11 FOXA2 KDM6A MAFF SMAD4 C2orf83 SCYGR4 LOC729968 HSALNG0022759-001
GH02J227626 Enhancer 0.4 FANTOM5 0.4 +9.8 9764 0.2 ATF2 CREB1 ATF7 CCL20 DAW1 LOC729968 SCYGR4 HSALNG0022759-001 C2orf83
GH02J227623 Enhancer 0.3 Ensembl 0.4 +6.4 6403 1.2 JUND FOS CCL20 LOC729968 SCYGR4 HSALNG0022759-001 C2orf83
GH02J227633 Promoter 0.3 EPDnew 0.4 +16.1 16134 0.1 LOC729968 C2orf83 SCYGR4 HSALNG0022759-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCYGR4 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for SCYGR4 Gene

Latest Assembly
chr2:227,616,998-227,618,655
(GRCh38/hg38)
Size:
1,658 bases
Orientation:
Plus strand

Genomic View for SCYGR4 Gene

Genes around SCYGR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCYGR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCYGR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for SCYGR4 Gene

Proteins for SCYGR4 Gene

  • Protein details for SCYGR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A286YEV6-SCGR4_HUMAN
    Recommended name:
    Small cysteine and glycine repeat-containing protein 4
    Protein Accession:
    A0A286YEV6

    Protein attributes for SCYGR4 Gene

    Size:
    105 amino acids
    Molecular mass:
    9792 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Human have a similar number of genes as other primates despite the relative hairlessness of humans.

neXtProt entry for SCYGR4 Gene

Post-translational modifications for SCYGR4 Gene

No Post-translational modifications

Other Protein References for SCYGR4 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for SCYGR4 Gene

Domains & Families for SCYGR4 Gene

Graphical View of Domain Structure for InterPro Entry

A0A286YEV6

UniProtKB/Swiss-Prot:

SCGR4_HUMAN :
  • Belongs to the KRTAP type 28 family.
Family:
  • Belongs to the KRTAP type 28 family.
genes like me logo Genes that share domains with SCYGR4: view

No data available for Gene Families , Protein Domains and Suggested Antigen Peptide Sequences for SCYGR4 Gene

Function for SCYGR4 Gene

Molecular function for SCYGR4 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes From GWAS Catalog for SCYGR4 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCYGR4 Gene

Localization for SCYGR4 Gene

Gene Ontology (GO) - Cellular Components for SCYGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with SCYGR4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SCYGR4 Gene

Pathways & Interactions for SCYGR4 Gene

PathCards logo

SuperPathways for SCYGR4 Gene

No Data Available

Interacting Proteins for SCYGR4 Gene

Gene Ontology (GO) - Biological Process for SCYGR4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCYGR4 Gene

Drugs & Compounds for SCYGR4 Gene

No Compound Related Data Available

Transcripts for SCYGR4 Gene

mRNA/cDNA for SCYGR4 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SCYGR4 Gene

No ASD Table

Relevant External Links for SCYGR4 Gene

GeneLoc Exon Structure for
SCYGR4

Expression for SCYGR4 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCYGR4 Gene

Orthologs for SCYGR4 Gene

Evolution for SCYGR4 Gene

ENSEMBL:
Gene Tree for SCYGR4 (if available)
TreeFam:
Gene Tree for SCYGR4 (if available)
Alliance of Genome Resources:
Additional Orthologs for SCYGR4

No data available for Orthologs for SCYGR4 Gene

Paralogs for SCYGR4 Gene

No data available for Paralogs for SCYGR4 Gene

Variants for SCYGR4 Gene

Additional Variant Information for SCYGR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCYGR4
Leiden Open Variation Database (LOVD)
SCYGR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SCYGR4 Gene

Disorders for SCYGR4 Gene

No disorders were found for SCYGR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SCYGR4 Gene

Publications for SCYGR4 Gene

  1. Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. (PMID: 18721477) Wu DD … Zhang YP (BMC evolutionary biology 2008) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4

No data available for Mastermind for SCYGR4 Gene

Products for SCYGR4 Gene

Sources for SCYGR4 Gene