Aliases for SCYGR3 Gene

Aliases for SCYGR3 Gene

  • Small Cysteine And Glycine Repeat Containing 3 2 3 5
  • KRTAP28-3 2 3 4
  • Keratin Associated Protein 28-3 2 3
  • Small Cysteine And Glycine Repeat-Containing Protein 3 4
  • Keratin-Associated Protein 28-3 4
  • SCYGR3 5

External Ids for SCYGR3 Gene

Summaries for SCYGR3 Gene

GeneCards Summary for SCYGR3 Gene

SCYGR3 (Small Cysteine And Glycine Repeat Containing 3) is a Protein Coding gene. An important paralog of this gene is SCYGR7.

UniProtKB/Swiss-Prot Summary for SCYGR3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for SCYGR3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCYGR3 Gene

Genomics for SCYGR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SCYGR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J227614 Enhancer 0.3 Ensembl 600.7 +1.1 1139 0.2 USF2 SCYGR3 SCYGR10 C2orf83
GH02J227608 Promoter 0.8 Ensembl 0.4 +6.0 6039 0.4 BACH1 LARP7 TCF12 IKZF2 EED ARID3A DPF2 RUNX3 GATAD2B CBFB SCYGR10 SCYGR3
GH02J227616 Enhancer 0.2 Ensembl 0.7 -2.1 -2061 0.6 ENSG00000236116 LOC729968 SCYGR4 SCYGR3 C2orf83
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCYGR3 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for SCYGR3 Gene

Genomic Locations for SCYGR3 Gene
chr2:227,614,538-227,614,840
(GRCh38/hg38)
Size:
303 bases
Orientation:
Minus strand

Genomic View for SCYGR3 Gene

Genes around SCYGR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCYGR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCYGR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for SCYGR3 Gene

Proteins for SCYGR3 Gene

  • Protein details for SCYGR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A286YF60-SCGR3_HUMAN
    Recommended name:
    Small cysteine and glycine repeat-containing protein 3
    Protein Accession:
    A0A286YF60

    Protein attributes for SCYGR3 Gene

    Size:
    100 amino acids
    Molecular mass:
    9511 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Human have a similar number of genes as other primates despite the relative hairlessness of humans.

neXtProt entry for SCYGR3 Gene

Post-translational modifications for SCYGR3 Gene

No Post-translational modifications

Other Protein References for SCYGR3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for SCYGR3 Gene

Domains & Families for SCYGR3 Gene

Protein Domains for SCYGR3 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A0A286YF60

UniProtKB/Swiss-Prot:

SCGR3_HUMAN :
  • Belongs to the KRTAP type 28 family.
Family:
  • Belongs to the KRTAP type 28 family.
genes like me logo Genes that share domains with SCYGR3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SCYGR3 Gene

Function for SCYGR3 Gene

Molecular function for SCYGR3 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes From GWAS Catalog for SCYGR3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCYGR3 Gene

Localization for SCYGR3 Gene

Gene Ontology (GO) - Cellular Components for SCYGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with SCYGR3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SCYGR3 Gene

Pathways & Interactions for SCYGR3 Gene

PathCards logo

SuperPathways for SCYGR3 Gene

No Data Available

Interacting Proteins for SCYGR3 Gene

Gene Ontology (GO) - Biological Process for SCYGR3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCYGR3 Gene

Drugs & Compounds for SCYGR3 Gene

No Compound Related Data Available

Transcripts for SCYGR3 Gene

mRNA/cDNA for SCYGR3 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SCYGR3 Gene

No ASD Table

Relevant External Links for SCYGR3 Gene

GeneLoc Exon Structure for
SCYGR3

Expression for SCYGR3 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCYGR3 Gene

Orthologs for SCYGR3 Gene

Evolution for SCYGR3 Gene

ENSEMBL:
Gene Tree for SCYGR3 (if available)
TreeFam:
Gene Tree for SCYGR3 (if available)

No data available for Orthologs for SCYGR3 Gene

Paralogs for SCYGR3 Gene

Paralogs for SCYGR3 Gene

genes like me logo Genes that share paralogs with SCYGR3: view

Variants for SCYGR3 Gene

Additional Variant Information for SCYGR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCYGR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SCYGR3 Gene

Disorders for SCYGR3 Gene

No disorders were found for SCYGR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SCYGR3 Gene

Publications for SCYGR3 Gene

  1. Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. (PMID: 18721477) Wu DD … Zhang YP (BMC evolutionary biology 2008) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4

No data available for Mastermind for SCYGR3 Gene

Products for SCYGR3 Gene

Sources for SCYGR3 Gene