SCX Gene (Protein Coding)

Scleraxis BHLH Transcription Factor

GC08P144265
GIFtS:
28

Aliases for SCX Gene

Aliases for SCX Gene

  • Scleraxis BHLH Transcription Factor 2 3 5
  • Basic Helix-Loop-Helix Transcription Factor Scleraxis 3 4
  • Scleraxis Basic Helix-Loop-Helix Transcription Factor 2 3
  • Class A Basic Helix-Loop-Helix Protein 41 3 4
  • Class A Basic Helix-Loop-Helix Protein 48 3 4
  • BHLHa48 3 4
  • SCXA 3 4
  • SCXB 3 4
  • Class II BHLH Protein Scleraxis 3
  • Scleraxis Homolog A (Mouse) 2
  • Scleraxis Homolog B (Mouse) 2
  • Scleraxis Homolog (Mouse) 2
  • Scleraxis Homolog A 3
  • Scleraxis Homolog B 3
  • BHLHA41 4
  • BHLHA48 4
  • BHLHa41 4

External Ids for SCX Gene

Previous HGNC Symbols for SCX Gene

  • SCXA
  • SCXB

Previous GeneCards Identifiers for SCX Gene

  • GC08U900014

Summaries for SCX Gene

GeneCards Summary for SCX Gene

SCX (Scleraxis BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with SCX include Lacrimoauriculodentodigital Syndrome and Anomalous Left Coronary Artery From The Pulmonary Artery. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is TCF15.

UniProtKB/Swiss-Prot Summary for SCX Gene

  • Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.

Gene Wiki entry for SCX Gene

Additional gene information for SCX Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCX Gene

Genomics for SCX Gene

GeneHancer (GH) Regulatory Elements for SCX Gene

Promoters and enhancers for SCX Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08J144266 Promoter/Enhancer 0.8 EPDnew Ensembl dbSUPER 500.7 +1.8 1841 1.8 SCX lnc-DGAT1-2 BOP1
GH08J144265 Promoter/Enhancer 0.5 Ensembl dbSUPER 500.7 +0.2 241 0.2 SCX lnc-DGAT1-2 BOP1
GH08J144264 Promoter/Enhancer 0.5 Ensembl dbSUPER 500.7 +0.6 641 0.2 SCX lnc-DGAT1-2 BOP1
GH08J144263 Enhancer 0.2 dbSUPER 500.7 -1.5 -1480 0.9 MIR7112 SCX BOP1
GH08J144290 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +27.8 27829 7 ZNF217 SIN3A NRF1 USF1 POLR2G GTF2E2 PHF8 ZFX ZIC2 POLR2A BOP1 HSF1 DGAT1 ENSG00000254690 TONSL-AS1 SCX PARP10 SPATC1 piR-57815-003
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCX on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCX

Genomic Locations for SCX Gene

Genomic Locations for SCX Gene
chr8:144,265,060-144,268,483
(GRCh38/hg38)
Size:
3,424 bases
Orientation:
Plus strand
chr8:145,321,517-145,323,045
(GRCh37/hg19)
Size:
1,529 bases
Orientation:
Plus strand

Genomic View for SCX Gene

Genes around SCX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCX Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SCX Gene

Proteins for SCX Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SCX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU7-SCX_HUMAN
    Recommended name:
    Basic helix-loop-helix transcription factor scleraxis
    Protein Accession:
    Q7RTU7

    Protein attributes for SCX Gene

    Size:
    201 amino acids
    Molecular mass:
    21596 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Dimerizes and binds the E-box consensus sequence with E12 (By similarity).

neXtProt entry for SCX Gene

Protein Expression for SCX Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SCX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCX Gene

Domains & Families for SCX Gene

Gene Families for SCX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SCX Gene

Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCX Gene

GenScript: Design optimal peptide antigens:
  • Class A basic helix-loop-helix protein 48 (SCX_HUMAN)
genes like me logo Genes that share domains with SCX: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SCX Gene

Function for SCX Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SCX Gene

UniProtKB/Swiss-Prot Function:
Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.

Gene Ontology (GO) - Molecular Function for SCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding ISS --
GO:0043425 bHLH transcription factor binding IEA,IPI 10775504
genes like me logo Genes that share ontologies with SCX: view
genes like me logo Genes that share phenotypes with SCX: view

Animal Models for SCX Gene

MGI Knock Outs for SCX:
  • Scx Scx<tm2Eno>
  • Scx Scx<tm1Eno>
  • Scx Scx<tm1.1Stzr>
  • Scx Scx<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCX

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCX Gene

Localization for SCX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCX gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IDA,IEA 10775504
GO:0005667 transcription factor complex IEA,IDA 10775504
genes like me logo Genes that share ontologies with SCX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCX Gene

Pathways & Interactions for SCX Gene

PathCards logo

SuperPathways for SCX Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation IEA,ISS --
GO:0001894 tissue homeostasis IEA,ISS --
GO:0001958 endochondral ossification IEA,ISS --
GO:0002062 chondrocyte differentiation ISS,IEA --
GO:0003179 heart valve morphogenesis ISS,IEA --
genes like me logo Genes that share ontologies with SCX: view

No data available for Pathways by source and SIGNOR curated interactions for SCX Gene

Drugs & Compounds for SCX Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SCX Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SCX Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCX

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCX Gene

No ASD Table

Relevant External Links for SCX Gene

GeneLoc Exon Structure for
SCX

Expression for SCX Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCX Gene

This gene is overexpressed in Urine (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCX Gene



Protein tissue co-expression partners for SCX Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCX

Evidence on tissue expression from TISSUES for SCX Gene

  • Urine(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with SCX: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCX Gene

Orthologs for SCX Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCX Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia SCXA 30
  • 90.17 (n)
cow
(Bos Taurus)
 Mammalia LOC615157 30
  • 89.22 (n)
mouse
(Mus musculus)
 Mammalia Scx 17 30
  • 87.56 (n)
rat
(Rattus norvegicus)
 Mammalia Scx 30
  • 87.4 (n)
chicken
(Gallus gallus)
 Aves SCXB 30
  • 78.97 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100490170 30
  • 72.68 (n)
zebrafish
(Danio rerio)
 Actinopterygii scxa 30
  • 67.03 (n)
Species where no ortholog for SCX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCX Gene

ENSEMBL:
Gene Tree for SCX (if available)
TreeFam:
Gene Tree for SCX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCX: view image

Paralogs for SCX Gene

Paralogs for SCX Gene

genes like me logo Genes that share paralogs with SCX: view

Variants for SCX Gene

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  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for SCX Gene

Structural Variations from Database of Genomic Variants (DGV) for SCX Gene

Variant ID Type Subtype PubMed ID
nsv1025071 CNV gain 25217958
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680

Additional Variant Information for SCX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SCX Gene

Disorders for SCX Gene

MalaCards: The human disease database

(2) MalaCards diseases for SCX Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search SCX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCX

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SCX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCX Gene

Publications for SCX Gene

  1. The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis. (PMID: 19362560) Espira L … Czubryt MP (Journal of molecular and cellular cardiology 2009) 2 3 54
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4 54
  3. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PMID: 12617822) McLellan AS … Kealey T (Gene expression patterns : GEP 2002) 3 4 54
  4. Regulation of cardiac fibroblast MMP2 gene expression by scleraxis. (PMID: 29750994) Nagalingam RS … Czubryt MP (Journal of molecular and cellular cardiology 2018) 3 54
  5. Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment. (PMID: 26851078) Hu JJ … Ouyang HW (Stem cells (Dayton, Ohio) 2016) 3 54

ExternalLinks

View latest publications for SCX gene in Mastermind

Products for SCX Gene

Sources for SCX Gene