Aliases for SCUBE2 Gene
External Ids for SCUBE2 Gene
Previous GeneCards Identifiers for SCUBE2 Gene
GeneCards Summary for SCUBE2 Gene
SCUBE2 (Signal Peptide, CUB Domain And EGF Like Domain Containing 2) is a Protein Coding gene. Diseases associated with SCUBE2 include Central Nervous System Tuberculosis and Tumoral Calcinosis, Hyperphosphatemic, Familial, 1. Among its related pathways are Signaling by GPCR and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is SCUBE1.
UniProtKB/Swiss-Prot Summary for SCUBE2 Gene
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).