The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008] See more...

Aliases for SCTR Gene

Aliases for SCTR Gene

  • Secretin Receptor 2 3 4 5
  • Pancreatic Secretin Receptor 3
  • SCT-R 4
  • SR 3

External Ids for SCTR Gene

Previous GeneCards Identifiers for SCTR Gene

  • GC02M117402
  • GC02M118118
  • GC02M120104
  • GC02M120292
  • GC02M119913
  • GC02M112522

Summaries for SCTR Gene

Entrez Gene Summary for SCTR Gene

  • The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCTR Gene

SCTR (Secretin Receptor) is a Protein Coding gene. Diseases associated with SCTR include Gastrinoma and Scott Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and secretin receptor activity. An important paralog of this gene is VIPR1.

UniProtKB/Swiss-Prot Summary for SCTR Gene

  • Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:7612008, PubMed:25332973). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).

Tocris Summary for SCTR Gene

  • Secretin receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2, GHRH and GIP receptors. Secretin receptors are classically localized to the epithelial cells within the pancreatic and biliary ducts, where they bind to the hormone secretin.

Gene Wiki entry for SCTR Gene

Additional gene information for SCTR Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCTR Gene

Genomics for SCTR Gene

GeneHancer (GH) Regulatory Elements for SCTR Gene

Promoters and enhancers for SCTR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J119520 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 515.6 +0.9 877 8.8 ZNF316 ZNF195 NFIC MAFF MAFK GTF2F1 SUZ12 EZH2 MAFG NFIB SCTR ENSG00000231013
GH02J119419 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 35.3 +97.2 97204 16.7 EP300 FOXK2 HNRNPK ZNF217 POLR2G NCOR1 TEAD4 ZNF639 KDM6A ZBTB10 TMEM37 SCTR ENSG00000231013 CFAP221 DBI STEAP3 piR-46847-125
GH02J119485 Enhancer 1.8 VISTA Ensembl ENCODE CraniofacialAtlas dbSUPER 35.7 +37.8 37801 11.8 EP300 FOXK2 ZNF217 NCOR1 JUND KDM6A ZNF623 TGIF2 SMARCC2 SKI ENSG00000231013 SCTR CFAP221 C1QL2
GH02J119541 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 15.2 -21.5 -21489 10.8 FOXK2 ZNF217 BCLAF1 JUND SIX5 PHB2 ZBTB26 TARDBP REST RFX1 CFAP221 SCTR TMEM185B TMEM177 EPB41L5 piR-32325-075
GH02J119365 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 17.1 +158.3 158300 4.4 EP300 ZBTB40 ZNF217 SIN3A NRF1 MYC USF1 POLR2G SP1 NCOR1 DBI C2orf76 FM213132 NONHSAG029091.2 lnc-SCTR-1 piR-52530 SCTR ENSG00000231013
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCTR on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCTR

Genomic Locations for SCTR Gene

Genomic Locations for SCTR Gene
chr2:119,439,843-119,525,301
(GRCh38/hg38)
Size:
85,459 bases
Orientation:
Minus strand
chr2:120,197,419-120,282,070
(GRCh37/hg19)
Size:
84,652 bases
Orientation:
Minus strand

Genomic View for SCTR Gene

Genes around SCTR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCTR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCTR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCTR Gene

Proteins for SCTR Gene

  • Protein details for SCTR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47872-SCTR_HUMAN
    Recommended name:
    Secretin receptor
    Protein Accession:
    P47872
    Secondary Accessions:
    • Q12961
    • Q13213
    • Q53T00

    Protein attributes for SCTR Gene

    Size:
    440 amino acids
    Molecular mass:
    50207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCTR Gene

Post-translational modifications for SCTR Gene

  • Phosphorylated on Ser and Thr residues at the cytoplasmic C-terminus by G protein-coupled receptor kinases (GRKs).
  • Glycosylation at Asn72, Asn100, Asn106, Asn128, and Asn291
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCTR Gene

Domains & Families for SCTR Gene

Gene Families for SCTR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for SCTR Gene

Blocks:
  • G-protein coupled receptors family 2 (secretin-like)
  • Secretin receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCTR Gene

GenScript: Design optimal peptide antigens:
  • Secretin receptor (Q8IV17_HUMAN)
  • Secretin receptor (SCTR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47872

UniProtKB/Swiss-Prot:

SCTR_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with SCTR: view

Function for SCTR Gene

Molecular function for SCTR Gene

UniProtKB/Swiss-Prot Function:
Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:7612008, PubMed:25332973). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).
GENATLAS Biochemistry:
secretin receptor,G protein coupled receptor superfamily,potent regulator of pancreatic secretion

Phenotypes From GWAS Catalog for SCTR Gene

Gene Ontology (GO) - Molecular Function for SCTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
GO:0015055 secretin receptor activity IDA 7612008
GO:0017046 peptide hormone binding IPI 7612008
genes like me logo Genes that share ontologies with SCTR: view
genes like me logo Genes that share phenotypes with SCTR: view

Animal Models for SCTR Gene

MGI Knock Outs for SCTR:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCTR

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCTR

Clone Products

  • Addgene plasmids for SCTR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCTR Gene

Localization for SCTR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCTR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCTR gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
extracellular 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SCTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCTR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCTR Gene

Pathways & Interactions for SCTR Gene

genes like me logo Genes that share pathways with SCTR: view

Gene Ontology (GO) - Biological Process for SCTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002024 diet induced thermogenesis ISS --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
GO:0007420 brain development IBA 21873635
genes like me logo Genes that share ontologies with SCTR: view

No data available for SIGNOR curated interactions for SCTR Gene

Drugs & Compounds for SCTR Gene

(9) Drugs for SCTR Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Secretin Approved Pharma Full agonist, Agonist, Target, ligand, binder 37
Secretin (rat) Pharma Gastrointestinal peptide 0
[(CH<sub>2</sub>NH)<sup>4,5</sup>]secretin Pharma Antagonist 0
VIP Pharma Agonist, Partial agonist 0
RG1068 Pharma 0

(5) Additional Compounds for SCTR Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I](Tyr<sup>10</sup>)secretin
Secretin (human)
108153-74-8

(2) Tocris Compounds for SCTR Gene

Compound Action Cas Number
Secretin (human) Gastrointestinal peptide 108153-74-8
Secretin (rat) Gastrointestinal peptide 121028-49-7

(1) ApexBio Compounds for SCTR Gene

Compound Action Cas Number
Secretin (rat) 121028-49-7
genes like me logo Genes that share compounds with SCTR: view

Drug Products

Transcripts for SCTR Gene

mRNA/cDNA for SCTR Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCTR

Clone Products

  • Addgene plasmids for SCTR

Alternative Splicing Database (ASD) splice patterns (SP) for SCTR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -

Relevant External Links for SCTR Gene

GeneLoc Exon Structure for
SCTR

Expression for SCTR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCTR Gene

mRNA differential expression in normal tissues according to GTEx for SCTR Gene

This gene is overexpressed in Pancreas (x39.7) and Kidney - Cortex (x4.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCTR

SOURCE GeneReport for Unigene cluster for SCTR Gene:

Hs.42091

Evidence on tissue expression from TISSUES for SCTR Gene

  • Pancreas(4.4)
  • Kidney(4.3)
  • Lung(4.1)
  • Liver(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with SCTR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCTR Gene

Orthologs for SCTR Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCTR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCTR 31 30
  • 99.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SCTR 31 30
  • 87.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SCTR 31 30
  • 87.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sctr 30
  • 84.69 (n)
mouse
(Mus musculus)
Mammalia Sctr 17 31 30
  • 84.09 (n)
oppossum
(Monodelphis domestica)
Mammalia SCTR 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCTR 31 30
  • 64.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCTR 31
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sctr 30
  • 57.32 (n)
ghrhra 31
  • 40 (a)
OneToMany
Species where no ortholog for SCTR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCTR Gene

ENSEMBL:
Gene Tree for SCTR (if available)
TreeFam:
Gene Tree for SCTR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCTR: view image

Paralogs for SCTR Gene

(15) SIMAP similar genes for SCTR Gene using alignment to 2 proteins:

  • SCTR_HUMAN
  • Q8IV17_HUMAN
genes like me logo Genes that share paralogs with SCTR: view

Variants for SCTR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCTR Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
708526 Benign: not provided 119,473,530(-) C/T MISSENSE_VARIANT
710544 Likely Benign: not provided 119,452,057(-) C/T MISSENSE_VARIANT
710545 Benign: not provided 119,464,135(-) G/A SYNONYMOUS_VARIANT
717175 Benign: not provided 119,461,998(-) C/T SYNONYMOUS_VARIANT
775755 Benign: not provided 119,464,191(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SCTR Gene

Structural Variations from Database of Genomic Variants (DGV) for SCTR Gene

Variant ID Type Subtype PubMed ID
esv2720634 CNV deletion 23290073
esv2762278 CNV loss 21179565
esv3592167 CNV gain 21293372
nsv1123375 CNV deletion 24896259
nsv459119 CNV gain 19166990
nsv582784 CNV gain 21841781
nsv955032 CNV deletion 24416366
nsv955077 CNV insertion 24416366

Variation tolerance for SCTR Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCTR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCTR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCTR Gene

Disorders for SCTR Gene

MalaCards: The human disease database

(6) MalaCards diseases for SCTR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastrinoma
  • gastrin cell tumour
scott syndrome
  • scts
jejunal somatostatinoma
  • jejunal delta cell somatostatin producing tumor
autism
  • autistic disorder
polycystic liver disease
  • congenital cystic liver disease
- elite association - COSMIC cancer census association via MalaCards
Search SCTR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCTR

genes like me logo Genes that share disorders with SCTR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCTR Gene

Publications for SCTR Gene

  1. Molecular cloning and functional expression of a human pancreatic secretin receptor. (PMID: 7864894) Jiang S … Ulrich C (Biochemical and biophysical research communications 1995) 3 4 23 54
  2. Molecular cloning and expression of a human secretin receptor. (PMID: 7700244) Patel DR … Sreedharan SP (Molecular pharmacology 1995) 3 4 23 54
  3. Molecular cloning and functional characterization of a human secretin receptor. (PMID: 7612008) Chow BK (Biochemical and biophysical research communications 1995) 3 4 23 54
  4. Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor. (PMID: 19904746) Onori P … Glaser SS (International journal of cancer 2010) 3 23 54
  5. Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. (PMID: 19886671) Harikumar KG … Miller LJ (Biochemistry 2009) 3 23 54

Products for SCTR Gene

Sources for SCTR Gene