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SCRT2 (Scratch Family Transcriptional Repressor 2) is a Protein Coding gene. Diseases associated with SCRT2 include Limited Scleroderma. Gene Ontology (GO) annotations related to this gene include proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is SCRT1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | ISS | -- |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | ISS | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISS | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,ISS | -- |
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | ISS | -- |
GO:2001222 | regulation of neuron migration | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | SCRT2 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Scrt2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Scrt2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SCRT2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SCRT2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SCRT2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | scrt2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17181 32 |
|
|
|
scrt 31 32 |
|
ManyToMany | |||
CG12605 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | K02D7.2 32 |
|
|
|
ces-1 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3644952 | CNV | gain | 21293372 |
nsv1067424 | CNV | gain | 25217958 |
nsv1160671 | CNV | duplication | 26073780 |
nsv952967 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
limited scleroderma |
|
|