Aliases for SCRT2 Gene

Aliases for SCRT2 Gene

  • Scratch Family Transcriptional Repressor 2 2 3 5
  • Transcriptional Repressor Scratch 2 3 4
  • Scratch (Drosophila Homolog) 2, Zinc Finger Protein 2
  • Scratch Homolog 2, Zinc Finger Protein (Drosophila) 2
  • Scratch Homolog 2, Zinc Finger Protein 3
  • Scratch Homolog 2 Zinc Finger Protein 4
  • Scratch Family Zinc Finger 2 3
  • Scratch 2 Protein 3
  • ZNF898B 3

External Ids for SCRT2 Gene

Previous GeneCards Identifiers for SCRT2 Gene

  • GC20M000632
  • GC20M000592
  • GC20M000639
  • GC20M000576
  • GC20M000591
  • GC20M000642
  • GC20M000593

Summaries for SCRT2 Gene

GeneCards Summary for SCRT2 Gene

SCRT2 (Scratch Family Transcriptional Repressor 2) is a Protein Coding gene. Diseases associated with SCRT2 include Limited Scleroderma. Gene Ontology (GO) annotations related to this gene include proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is SCRT1.

UniProtKB/Swiss-Prot Summary for SCRT2 Gene

Additional gene information for SCRT2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCRT2 Gene

Genomics for SCRT2 Gene

GeneHancer (GH) Regulatory Elements for SCRT2 Gene

Promoters and enhancers for SCRT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J000672 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 750.6 +1.2 1178 3.6 CTCF RBPJ TCF7L2 TRIM22 HLF MAX MNT IKZF1 RERE NKRF ENSG00000270299 SCRT2 ACTG1P3 LOC105372491 KR021991
GH20J000677 Enhancer 0.2 Ensembl 750.6 -1.8 -1821 0.8 SCRT2 KR021991 LOC105372491 piR-36140
GH20J000645 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 11.7 +30.0 29957 2.3 SIN3A CTCF MLX RBPJ NR2F1 NR2F6 MIXL1 CC2D1A ELF1 HLF SRXN1 ACTG1P3 TCF15 CSNK2A1 SCRT2 SLC52A3 HSALNG0128051 ENSG00000270299
GH20J000728 Promoter/Enhancer 1.2 CraniofacialAtlas dbSUPER 12.6 -52.1 -52078 0.2 CTCF ZNF148 ZFX SP7 ZSCAN21 PPARG EGR1 GMEB1 GLIS2 ZBTB8A SCRT2 SRXN1 SLC52A3 CSNK2A1 ANGPT4 RF00017-3485 piR-38580-176 KR021991
GH20J000727 Enhancer 1.1 ENCODE dbSUPER 12.6 -52.4 -52373 0.2 CTCF CC2D1A RAD21 ZNF148 GTF2F1 ZFX AHR CEBPG TFE3 SP7 NRSN2 SCRT2 SRXN1 SLC52A3 CSNK2A1 SOX12 ANGPT4 RF00017-3485 piR-38580-176 KR021991
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCRT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCRT2 gene promoter:
  • Arnt
  • ITF-2
  • Nkx2-5
  • RSRFC4
  • Tal-1beta
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2
  • YY1

Genomic Locations for SCRT2 Gene

Genomic Locations for SCRT2 Gene
chr20:661,596-676,179
(GRCh38/hg38)
Size:
14,584 bases
Orientation:
Minus strand
chr20:642,240-656,823
(GRCh37/hg19)
Size:
14,584 bases
Orientation:
Minus strand

Genomic View for SCRT2 Gene

Genes around SCRT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRT2 Gene

Proteins for SCRT2 Gene

  • Protein details for SCRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ03-SCRT2_HUMAN
    Recommended name:
    Transcriptional repressor scratch 2
    Protein Accession:
    Q9NQ03

    Protein attributes for SCRT2 Gene

    Size:
    307 amino acids
    Molecular mass:
    32584 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRT2 Gene

Post-translational modifications for SCRT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCRT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCRT2 Gene

Domains & Families for SCRT2 Gene

Gene Families for SCRT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SCRT2 Gene

Suggested Antigen Peptide Sequences for SCRT2 Gene

GenScript: Design optimal peptide antigens:
  • Scratch homolog 2 zinc finger protein (SCRT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NQ03

UniProtKB/Swiss-Prot:

SCRT2_HUMAN :
  • Belongs to the snail C2H2-type zinc-finger protein family.
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SCRT2: view

Function for SCRT2 Gene

Molecular function for SCRT2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for SCRT2 Gene

Gene Ontology (GO) - Molecular Function for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific ISS --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
genes like me logo Genes that share ontologies with SCRT2: view
genes like me logo Genes that share phenotypes with SCRT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCRT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRT2 Gene

Localization for SCRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCRT2 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISS --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with SCRT2: view

Pathways & Interactions for SCRT2 Gene

PathCards logo

SuperPathways for SCRT2 Gene

No Data Available

Interacting Proteins for SCRT2 Gene

Gene Ontology (GO) - Biological Process for SCRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS --
GO:2001222 regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with SCRT2: view

No data available for Pathways by source and SIGNOR curated interactions for SCRT2 Gene

Drugs & Compounds for SCRT2 Gene

No Compound Related Data Available

Transcripts for SCRT2 Gene

mRNA/cDNA for SCRT2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(234) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCRT2

Alternative Splicing Database (ASD) splice patterns (SP) for SCRT2 Gene

No ASD Table

Relevant External Links for SCRT2 Gene

GeneLoc Exon Structure for
SCRT2
ECgene alternative splicing isoforms for
SCRT2

Expression for SCRT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCRT2 Gene

This gene is overexpressed in Brain - Cerebellum (x13.1), Brain - Cerebellar Hemisphere (x10.6), Brain - Frontal Cortex (BA9) (x7.0), and Brain - Cortex (x6.5).

Protein differential expression in normal tissues from HIPED for SCRT2 Gene

This gene is overexpressed in Bone (55.7) and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCRT2 Gene



Protein tissue co-expression partners for SCRT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCRT2 Gene:

SCRT2

SOURCE GeneReport for Unigene cluster for SCRT2 Gene:

Hs.355284
genes like me logo Genes that share expression patterns with SCRT2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCRT2 Gene

Orthologs for SCRT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCRT2 32
  • 92.66 (n)
rat
(Rattus norvegicus)
Mammalia Scrt2 32
  • 90.74 (n)
mouse
(Mus musculus)
Mammalia Scrt2 17 33 32
  • 90.05 (n)
oppossum
(Monodelphis domestica)
Mammalia SCRT2 33
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRT2 33 32
  • 77.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCRT2 33
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii scrt2 33 32
  • 65.48 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17181 34
  • 65 (a)
scrt 33 34
  • 24 (a)
ManyToMany
CG12605 33 34
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K02D7.2 34
  • 56 (a)
ces-1 33
  • 39 (a)
ManyToMany
Species where no ortholog for SCRT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCRT2 Gene

ENSEMBL:
Gene Tree for SCRT2 (if available)
TreeFam:
Gene Tree for SCRT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCRT2: view image

Paralogs for SCRT2 Gene

Variants for SCRT2 Gene

Sequence variations from dbSNP and Humsavar for SCRT2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000191534 -- 663,299(-) G/A 3_prime_UTR_variant
rs1000290892 -- 674,161(-) TGATGA/TGA intron_variant
rs1000349505 -- 670,341(-) C/T intron_variant
rs1000407895 -- 663,015(-) G/C 3_prime_UTR_variant
rs1000713232 -- 669,900(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SCRT2 Gene

Variant ID Type Subtype PubMed ID
esv3644952 CNV gain 21293372
nsv1067424 CNV gain 25217958
nsv1160671 CNV duplication 26073780
nsv952967 CNV deletion 24416366

Variation tolerance for SCRT2 Gene

Gene Damage Index Score: 1.44; 28.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCRT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCRT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRT2 Gene

Disorders for SCRT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCRT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
limited scleroderma
  • crest syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SCRT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCRT2

genes like me logo Genes that share disorders with SCRT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRT2 Gene

Publications for SCRT2 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 56
  2. Mammalian Scratch: a neural-specific Snail family transcriptional repressor. (PMID: 11274425) Nakakura EK … Ball DW (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 56
  3. Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism. (PMID: 23434913) Itoh Y … Gotoh Y (Nature neuroscience 2013) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. (PMID: 21252910) Rodríguez-Aznar E … Nieto MA (Cell death and differentiation 2011) 3 56

Products for SCRT2 Gene

Sources for SCRT2 Gene