Aliases for SCRN2 Gene

Aliases for SCRN2 Gene

  • Secernin 2 2 3 5
  • Secernin-2 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Ses2 3

External Ids for SCRN2 Gene

Previous GeneCards Identifiers for SCRN2 Gene

  • GC17M046390
  • GC17M043270
  • GC17M045915
  • GC17M041283

Summaries for SCRN2 Gene

GeneCards Summary for SCRN2 Gene

SCRN2 (Secernin 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include dipeptidase activity. An important paralog of this gene is SCRN3.

Additional gene information for SCRN2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCRN2 Gene

Genomics for SCRN2 Gene

GeneHancer (GH) Regulatory Elements for SCRN2 Gene

Promoters and enhancers for SCRN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCRN2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCRN2

Top Transcription factor binding sites by QIAGEN in the SCRN2 gene promoter:
  • HOXA5
  • NF-kappaB
  • NF-kappaB1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2 (Oct-2.1)
  • Zic3

Genomic Locations for SCRN2 Gene

Genomic Locations for SCRN2 Gene
chr17:47,837,681-47,841,333
(GRCh38/hg38)
Size:
3,653 bases
Orientation:
Minus strand
chr17:45,915,047-45,918,699
(GRCh37/hg19)
Size:
3,653 bases
Orientation:
Minus strand

Genomic View for SCRN2 Gene

Genes around SCRN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRN2 Gene

Proteins for SCRN2 Gene

  • Protein details for SCRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FV2-SCRN2_HUMAN
    Recommended name:
    Secernin-2
    Protein Accession:
    Q96FV2
    Secondary Accessions:
    • A8K3N1
    • B7Z8S7
    • E9PBV5
    • Q96AC3
    • Q9BU04

    Protein attributes for SCRN2 Gene

    Size:
    425 amino acids
    Molecular mass:
    46597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10408.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SCRN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCRN2 Gene

Post-translational modifications for SCRN2 Gene

  • Ubiquitination at Lys215 and Lys272
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCRN2 Gene

Domains & Families for SCRN2 Gene

Gene Families for SCRN2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SCRN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRN2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56558, highly similar to Homo sapiens secernin 2 (SCRN2), mRNA (B7Z8S7_HUMAN)
  • Secernin-2 (SCRN2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96FV2

UniProtKB/Swiss-Prot:

SCRN2_HUMAN :
  • Belongs to the peptidase C69 family. Secernin subfamily.
Family:
  • Belongs to the peptidase C69 family. Secernin subfamily.
genes like me logo Genes that share domains with SCRN2: view

Function for SCRN2 Gene

Phenotypes From GWAS Catalog for SCRN2 Gene

Gene Ontology (GO) - Molecular Function for SCRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21044950
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with SCRN2: view
genes like me logo Genes that share phenotypes with SCRN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCRN2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCRN2 Gene

Localization for SCRN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCRN2 gene
Compartment Confidence
nucleus 3
extracellular 2
golgi apparatus 2
cytoskeleton 1
cytosol 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with SCRN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SCRN2 Gene

Pathways & Interactions for SCRN2 Gene

PathCards logo

SuperPathways for SCRN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SCRN2: view

No data available for Pathways by source and SIGNOR curated interactions for SCRN2 Gene

Drugs & Compounds for SCRN2 Gene

No Compound Related Data Available

Transcripts for SCRN2 Gene

mRNA/cDNA for SCRN2 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCRN2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - -
SP10: - - - - - -
SP11: - - - -
SP12:
SP13: -

ExUns: 9a · 9b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SCRN2 Gene

GeneLoc Exon Structure for
SCRN2

Expression for SCRN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCRN2 Gene

Protein differential expression in normal tissues from HIPED for SCRN2 Gene

This gene is overexpressed in Nasopharynx (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCRN2 Gene



Protein tissue co-expression partners for SCRN2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCRN2

SOURCE GeneReport for Unigene cluster for SCRN2 Gene:

Hs.239718

Evidence on tissue expression from TISSUES for SCRN2 Gene

  • Liver(4.2)
  • Lung(4.2)
  • Skin(4.2)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SCRN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCRN2 Gene

Orthologs for SCRN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCRN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCRN2 31 30
  • 99.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SCRN2 31 30
  • 88.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SCRN2 31 30
  • 87.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Scrn2 17 31 30
  • 84.1 (n)
rat
(Rattus norvegicus)
Mammalia Scrn2 30
  • 83.86 (n)
oppossum
(Monodelphis domestica)
Mammalia SCRN2 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRN2 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRN2 31 30
  • 71.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCRN2 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scrn2 30
  • 66.86 (n)
zebrafish
(Danio rerio)
Actinopterygii scrn2 31 30
  • 63.45 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10098 31
  • 25 (a)
OneToMany
Species where no ortholog for SCRN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCRN2 Gene

ENSEMBL:
Gene Tree for SCRN2 (if available)
TreeFam:
Gene Tree for SCRN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCRN2: view image

Paralogs for SCRN2 Gene

Paralogs for SCRN2 Gene

(2) SIMAP similar genes for SCRN2 Gene using alignment to 7 proteins:

  • SCRN2_HUMAN
  • J3KS57_HUMAN
  • J3KT79_HUMAN
  • J3QL71_HUMAN
  • J3QQM9_HUMAN
  • J3QR84_HUMAN
  • J3QRJ1_HUMAN
genes like me logo Genes that share paralogs with SCRN2: view

Variants for SCRN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCRN2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs17856535 - p.Ser411Gly
rs17856536 - p.Lys103Arg
rs34480825 - p.Gln330Arg
rs35901087 - p.Glu273Gln
rs7350974 - p.Met323Val

Additional dbSNP identifiers (rs#s) for SCRN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SCRN2 Gene

Variant ID Type Subtype PubMed ID
dgv947e212 CNV loss 25503493
nsv517880 CNV loss 19592680
nsv518892 CNV loss 19592680

Variation tolerance for SCRN2 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCRN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCRN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCRN2 Gene

Disorders for SCRN2 Gene

Additional Disease Information for SCRN2

No disorders were found for SCRN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCRN2 Gene

Publications for SCRN2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. (PMID: 12221138) Way G … O'Sullivan AJ (Molecular biology of the cell 2002) 2 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 54

Products for SCRN2 Gene

Sources for SCRN2 Gene