Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bon... See more...

Aliases for SCRG1 Gene

Aliases for SCRG1 Gene

  • Stimulator Of Chondrogenesis 1 2 3 5
  • Scrapie-Responsive Gene 1 Protein 3 4
  • Scrapie-Responsive Protein 1 3 4
  • Scrapie Responsive Gene 1 2 3
  • SCRG-1 3
  • ScRG-1 4

External Ids for SCRG1 Gene

Previous GeneCards Identifiers for SCRG1 Gene

  • GC04M175229
  • GC04M174847
  • GC04M175005
  • GC04M174684
  • GC04M174545
  • GC04M174309
  • GC04M170057

Summaries for SCRG1 Gene

Entrez Gene Summary for SCRG1 Gene

  • Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]

GeneCards Summary for SCRG1 Gene

SCRG1 (Stimulator Of Chondrogenesis 1) is a Protein Coding gene. Diseases associated with SCRG1 include Scrapie and Deafness, Autosomal Dominant 24.

Additional gene information for SCRG1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCRG1 Gene

Genomics for SCRG1 Gene

GeneHancer (GH) Regulatory Elements for SCRG1 Gene

Promoters and enhancers for SCRG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J173520 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.2 -50.5 -50496 12.5 NRF1 REST ZBTB26 CTBP1 MXI1 EZH2 CTCF TCF7L2 POLR2A GABPA HAND2-AS1 HAND2 SCRG1 lnc-HAND2-2
GH04J173414 Promoter/Enhancer 1.4 EPDnew FANTOM5 ENCODE 500.2 +60.2 60152 0.7 ZNF217 EP300 ZNF639 KLF4 TOE1 NFRKB TRIM25 GATAD2B CTBP1 MIER1 SCRG1 HMGB2 SAP30 RPL5P11 lnc-SAP30-11 LOC101928383
GH04J173516 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 500.3 -41.4 -41427 4.1 TEAD4 EZH2 MXI1 NR2F2 POLR2A USF1 CBX8 RCOR1 CTCF SMARCA4 lnc-SAP30-21 lnc-SAP30-22 SCRG1 RNU6-1096P HAND2-AS1 lnc-HAND2-2
GH04J173399 Promoter 0.9 EPDnew Ensembl 500.2 +77.9 77890 0.8 ATF4 ATF3 CEBPB ENSG00000288025 SCRG1 lnc-HMGB2-7 MK732524 LOC101928383
GH04J173466 Promoter/Enhancer 0.6 EPDnew Ensembl 500.4 +10.5 10490 0.4 NR3C1 SCRG1 ENSG00000261646 RF00026-839 RNU6-1096P lnc-HAND2-2 LOC101928383
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCRG1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCRG1

Top Transcription factor binding sites by QIAGEN in the SCRG1 gene promoter:
  • AML1a
  • FOXD3
  • GATA-2
  • HEN1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • STAT5A
  • TBP
  • TFIID

Genomic Locations for SCRG1 Gene

Genomic Locations for SCRG1 Gene
chr4:173,384,701-173,476,691
(GRCh38/hg38)
Size:
91,991 bases
Orientation:
Minus strand
chr4:174,305,852-174,327,531
(GRCh37/hg19)
Size:
21,680 bases
Orientation:
Minus strand

Genomic View for SCRG1 Gene

Genes around SCRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCRG1 Gene

Proteins for SCRG1 Gene

  • Protein details for SCRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75711-SCRG1_HUMAN
    Recommended name:
    Scrapie-responsive protein 1
    Protein Accession:
    O75711

    Protein attributes for SCRG1 Gene

    Size:
    98 amino acids
    Molecular mass:
    11081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCRG1 Gene

Post-translational modifications for SCRG1 Gene

  • Glycosylation at Asn72
  • Modification sites at PhosphoSitePlus

Other Protein References for SCRG1 Gene

No data available for DME Specific Peptides for SCRG1 Gene

Domains & Families for SCRG1 Gene

Gene Families for SCRG1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SCRG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCRG1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92430, Homo sapiens scrapie responsive protein 1 (SCRG1), mRNA (Q6FGG5_HUMAN)
  • Scrapie-responsive gene 1 protein (SCRG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75711

UniProtKB/Swiss-Prot:

SCRG1_HUMAN :
  • Belongs to the SCRG1 family.
Family:
  • Belongs to the SCRG1 family.
genes like me logo Genes that share domains with SCRG1: view

Function for SCRG1 Gene

Phenotypes From GWAS Catalog for SCRG1 Gene

Gene Ontology (GO) - Molecular Function for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCRG1: view
genes like me logo Genes that share phenotypes with SCRG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCRG1

CRISPR Products

miRNA for SCRG1 Gene

miRTarBase miRNAs that target SCRG1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCRG1 Gene

Localization for SCRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCRG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCRG1 gene
Compartment Confidence
extracellular 5
golgi apparatus 3
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 9660755
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IBA,IEA 21873635
GO:0044306 neuron projection terminus IBA 21873635
genes like me logo Genes that share ontologies with SCRG1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCRG1 Gene

Pathways & Interactions for SCRG1 Gene

PathCards logo

SuperPathways for SCRG1 Gene

No Data Available

Interacting Proteins for SCRG1 Gene

;

Gene Ontology (GO) - Biological Process for SCRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9660755
GO:0097168 mesenchymal stem cell proliferation IDA --
genes like me logo Genes that share ontologies with SCRG1: view

No data available for Pathways by source and SIGNOR curated interactions for SCRG1 Gene

Drugs & Compounds for SCRG1 Gene

No Compound Related Data Available

Transcripts for SCRG1 Gene

mRNA/cDNA for SCRG1 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCRG1 Gene

No ASD Table

Relevant External Links for SCRG1 Gene

GeneLoc Exon Structure for
SCRG1

Expression for SCRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCRG1 Gene

mRNA differential expression in normal tissues according to GTEx for SCRG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2).

Protein differential expression in normal tissues from HIPED for SCRG1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCRG1 Gene



Protein tissue co-expression partners for SCRG1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCRG1

SOURCE GeneReport for Unigene cluster for SCRG1 Gene:

Hs.7122

mRNA Expression by UniProt/SwissProt for SCRG1 Gene:

O75711-SCRG1_HUMAN
Tissue specificity: Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High levels of SCRG1 transcripts are also observed in testis and aorta.

Evidence on tissue expression from TISSUES for SCRG1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with SCRG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCRG1 Gene

Orthologs for SCRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCRG1 31 30
  • 99.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SCRG1 31 30
  • 92.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SCRG1 31
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scrg1 17 31 30
  • 85.22 (n)
rat
(Rattus norvegicus)
Mammalia Scrg1 30
  • 83.85 (n)
oppossum
(Monodelphis domestica)
Mammalia SCRG1 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRG1 31
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRG1 31 30
  • 67.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCRG1 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scrg1 30
  • 69.23 (n)
Species where no ortholog for SCRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCRG1 Gene

ENSEMBL:
Gene Tree for SCRG1 (if available)
TreeFam:
Gene Tree for SCRG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCRG1: view image

Paralogs for SCRG1 Gene

No data available for Paralogs for SCRG1 Gene

Variants for SCRG1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCRG1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs2306465 - p.Pro42Leu

Additional dbSNP identifiers (rs#s) for SCRG1 Gene

Variation tolerance for SCRG1 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCRG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCRG1 Gene

Disorders for SCRG1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SCRG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
scrapie
deafness, autosomal dominant 24
  • dfna24
prion disease
  • prion disease pathway
- elite association - COSMIC cancer census association via MalaCards
Search SCRG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCRG1

genes like me logo Genes that share disorders with SCRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCRG1 Gene

Publications for SCRG1 Gene

  1. Characterization of the human analogue of a Scrapie-responsive gene. (PMID: 9660755) Dron M … Tovey MG (The Journal of biological chemistry 1998) 2 3 4 23 54
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 54
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  4. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. (PMID: 9516475) Dandoy-Dron F … Dron M (The Journal of biological chemistry 1998) 2 3 54
  5. linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin. (PMID: 30226813) Wu JC … Xu MY (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3 54

Products for SCRG1 Gene

Sources for SCRG1 Gene