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Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]
SCRG1 (Stimulator Of Chondrogenesis 1) is a Protein Coding gene. Diseases associated with SCRG1 include Scrapie.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | TAS | 9660755 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005794 | Golgi apparatus | IEA,IBA | 21873635 |
GO:0044306 | neuron projection terminus | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007399 | nervous system development | TAS | 9660755 |
GO:0097168 | mesenchymal stem cell proliferation | IDA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SCRG1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SCRG1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SCRG1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Scrg1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Scrg1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SCRG1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SCRG1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SCRG1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SCRG1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | scrg1 30 |
|
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2306465 | - |
p.Pro42Leu |
Disorder | Aliases | PubMed IDs |
---|---|---|
scrapie |
|
|