Aliases for SCP2 Gene
External Ids for SCP2 Gene
Previous GeneCards Identifiers for SCP2 Gene
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]
GeneCards Summary for SCP2 Gene
SCP2 (Sterol Carrier Protein 2) is a Protein Coding gene. Diseases associated with SCP2 include Leukoencephalopathy With Dystonia And Motor Neuropathy and Wheat Allergy. Among its related pathways are DNA Damage Response (only ATM dependent) and Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF). Gene Ontology (GO) annotations related to this gene include receptor binding and cholesterol binding. An important paralog of this gene is HSD17B4.
UniProtKB/Swiss-Prot for SCP2 Gene
Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.