This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] See more...

Aliases for SCOC Gene

Aliases for SCOC Gene

  • Short Coiled-Coil Protein 2 3 4 5
  • SCOCO 3 4
  • Short Coiled Coil Protein 2
  • HRIHFB2072 3
  • UNC-69 3

External Ids for SCOC Gene

Previous GeneCards Identifiers for SCOC Gene

  • GC04P141490
  • GC04P141644
  • GC04P141756
  • GC04P141536
  • GC04P141178
  • GC04P136908

Summaries for SCOC Gene

Entrez Gene Summary for SCOC Gene

  • This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for SCOC Gene

SCOC (Short Coiled-Coil Protein) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Retrograde transport at the Trans-Golgi-Network.

UniProtKB/Swiss-Prot Summary for SCOC Gene

Additional gene information for SCOC Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCOC Gene

Genomics for SCOC Gene

GeneHancer (GH) Regulatory Elements for SCOC Gene

Promoters and enhancers for SCOC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J140372 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.1 +116.4 116415 3 SP1 ZBTB6 RBPJ POLR2A ATF1 FOS CREB1 CC2D1A NFYC HLF SCOC-AS1 SCOC CLGN UCP1
GH04J139733 Promoter/Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas 11.3 -522.4 -522440 3.6 ZBTB40 CTCF HLF RAD21 SP7 PRDM1 IKZF1 ZBTB8A PRDM10 ZEB2 SCOC MAML3 lnc-RAB33B-9 lnc-MGST2-3 MGST2
GH04J140295 Enhancer 1 FANTOM5 ENCODE 13.3 +39.2 39223 2 USF2 BCL6B SP7 ZSCAN21 PRDM1 EGR1 DPF2 RXRA PRDM10 ZNF639 SCOC UCP1 MAML3 lnc-CLGN-4 NDUFB4P9 HSALNG0037482 SCOC-AS1
GH04J140130 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -122.7 -122700 8.8 NFIB MAFK SP7 POLR2A CEBPB ZNF692 JUN ZNF561 JUND ZNF37A SCOC ENSG00000250698 LOC101927516 lnc-CLGN-5 MAML3
GH04J139738 Enhancer 1.1 ENCODE CraniofacialAtlas 11.3 -517.0 -516967 3.5 FOXA1 MLX RBPJ ATF1 NR2F6 MIXL1 NFYC HLF L3MBTL2 RAD21 SCOC lnc-RAB33B-9 lnc-MGST2-3 MGST2 MAML3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCOC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCOC gene promoter:
  • AP-4
  • AREB6
  • Bach2
  • C/EBPalpha
  • Cdc5
  • CREB
  • NF-1
  • POU2F1
  • POU2F1a
  • SEF-1 (1)

Genomic Locations for SCOC Gene

Genomic Locations for SCOC Gene
chr4:140,257,286-140,385,726
(GRCh38/hg38)
Size:
128,441 bases
Orientation:
Plus strand
chr4:141,178,440-141,306,880
(GRCh37/hg19)
Size:
128,441 bases
Orientation:
Plus strand

Genomic View for SCOC Gene

Genes around SCOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCOC Gene

Proteins for SCOC Gene

  • Protein details for SCOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIL1-SCOC_HUMAN
    Recommended name:
    Short coiled-coil protein
    Protein Accession:
    Q9UIL1
    Secondary Accessions:
    • B7WPH7
    • D3DNY7
    • E9PB65
    • Q6P5T9
    • Q7L2Y0
    • Q7Z4P2
    • Q96JY9
    • Q9BZB2

    Protein attributes for SCOC Gene

    Size:
    159 amino acids
    Molecular mass:
    18045 Da
    Quaternary structure:
    • Homodimer (PubMed:24098481). Interacts with ARL1, ARL2 and ARL3 (PubMed:11303027). Directly interacts with FEZ1 and UVRAG (PubMed:22354037, PubMed:24098481). The interaction with UVRAG is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with NRBF2 (PubMed:22354037).
    SequenceCaution:
    • Sequence=AAK01707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP97732.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCOC Gene

    Alternative splice isoforms for SCOC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCOC Gene

Post-translational modifications for SCOC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCOC Gene

Domains & Families for SCOC Gene

Gene Families for SCOC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SCOC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCOC Gene

GenScript: Design optimal peptide antigens:
  • Short coiled-coil protein (SCOC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UIL1

UniProtKB/Swiss-Prot:

SCOC_HUMAN :
  • Belongs to the SCOC family.
Family:
  • Belongs to the SCOC family.
genes like me logo Genes that share domains with SCOC: view

Function for SCOC Gene

Molecular function for SCOC Gene

UniProtKB/Swiss-Prot Function:
Positive regulator of amino acid starvation-induced autophagy.

Phenotypes From GWAS Catalog for SCOC Gene

Gene Ontology (GO) - Molecular Function for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with SCOC: view
genes like me logo Genes that share phenotypes with SCOC: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCOC Gene

Localization for SCOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCOC Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCOC gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005768 colocalizes_with endosome IDA 22354037
GO:0005794 Golgi apparatus IDA,IEA --
genes like me logo Genes that share ontologies with SCOC: view

Pathways & Interactions for SCOC Gene

genes like me logo Genes that share pathways with SCOC: view

Gene Ontology (GO) - Biological Process for SCOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016239 positive regulation of macroautophagy IDA 22354037
GO:0061635 regulation of protein complex stability IMP 22354037
genes like me logo Genes that share ontologies with SCOC: view

No data available for SIGNOR curated interactions for SCOC Gene

Drugs & Compounds for SCOC Gene

No Compound Related Data Available

Transcripts for SCOC Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCOC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - - - - - -
SP8: - -
SP9:

Relevant External Links for SCOC Gene

GeneLoc Exon Structure for
SCOC
ECgene alternative splicing isoforms for
SCOC

Expression for SCOC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCOC Gene

This gene is overexpressed in Salivary gland (12.9), Heart (10.9), Amniocyte (8.9), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCOC Gene



NURSA nuclear receptor signaling pathways regulating expression of SCOC Gene:

SCOC

SOURCE GeneReport for Unigene cluster for SCOC Gene:

Hs.480815

mRNA Expression by UniProt/SwissProt for SCOC Gene:

Q9UIL1-SCOC_HUMAN
Tissue specificity: Widely expressed with highest levels in brain, heart and skeletal muscle.

Evidence on tissue expression from TISSUES for SCOC Gene

  • Nervous system(5)
  • Lung(4.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with SCOC: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCOC Gene

Orthologs for SCOC Gene

This gene was present in the common ancestor of animals.

Orthologs for SCOC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100296832 32
  • 94.95 (n)
SCOC 33
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCOC 33 32
  • 94.26 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Scoc 17 33 32
  • 88.8 (n)
rat
(Rattus norvegicus)
Mammalia Scoc 32
  • 87.98 (n)
chimpanzee
(Pan troglodytes)
Mammalia SCOC 33
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCOC 33
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCOC 33
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves BERT 33
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCOC 33
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scoc 32
  • 67.54 (n)
Str.7270 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.8663 32
zebrafish
(Danio rerio)
Actinopterygii scocb 33
  • 95 (a)
OneToMany
scoca 33 32
  • 69.32 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10458 32
fruit fly
(Drosophila melanogaster)
Insecta CG5934 33
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-69 33
  • 29 (a)
OneToOne
Species where no ortholog for SCOC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCOC Gene

ENSEMBL:
Gene Tree for SCOC (if available)
TreeFam:
Gene Tree for SCOC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCOC: view image

Paralogs for SCOC Gene

Pseudogenes.org Pseudogenes for SCOC Gene

genes like me logo Genes that share paralogs with SCOC: view

No data available for Paralogs for SCOC Gene

Variants for SCOC Gene

Sequence variations from dbSNP and Humsavar for SCOC Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000005162 -- 140,294,676(+) TAT/T genic_upstream_transcript_variant, intron_variant
rs1000012045 -- 140,340,602(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000045911 -- 140,296,018(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000064272 -- 140,287,944(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000078209 -- 140,341,822(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SCOC Gene

Variant ID Type Subtype PubMed ID
dgv2912n106 CNV duplication 24896259
dgv3087e59 CNV duplication 20981092
esv1182482 CNV insertion 17803354
esv2668516 CNV deletion 23128226
esv2728435 CNV deletion 23290073
esv2728436 CNV deletion 23290073
esv3564722 CNV deletion 23714750
esv3602451 CNV loss 21293372
nsv1074757 CNV deletion 25765185
nsv1077973 CNV duplication 25765185
nsv1123850 CNV deletion 24896259
nsv1146992 CNV deletion 26484159
nsv1154121 CNV duplication 26484159

Variation tolerance for SCOC Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCOC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCOC Gene

Disorders for SCOC Gene

Additional Disease Information for SCOC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SCOC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCOC Gene

Publications for SCOC Gene

  1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H … Kahn RA (The Journal of biological chemistry 2001) 2 3 4 56
  2. Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation. (PMID: 24098481) Behrens C … Kühnel K (PloS one 2013) 3 4 56
  3. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight NC … Tooze SA (The EMBO journal 2012) 3 4 56
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for SCOC Gene

Sources for SCOC Gene