Aliases for SCN9A Gene
- Sodium Voltage-Gated Channel Alpha Subunit 9 2 3 5
- NENA 2 3 4
- PN1 2 3 4
- Sodium Channel, Voltage-Gated, Type IX, Alpha Polypeptide 2 3
- Sodium Channel, Voltage-Gated, Type IX, Alpha Subunit 2 3
- Voltage-Gated Sodium Channel Subunit Alpha Nav1.7 3 4
- Sodium Channel Protein Type IX Subunit Alpha 3 4
- Sodium Channel Protein Type 9 Subunit Alpha 3 4
- Neuroendocrine Sodium Channel 3 4
- Peripheral Sodium Channel 1 3 4
External Ids for SCN9A Gene
Previous GeneCards Identifiers for SCN9A Gene
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
GeneCards Summary for SCN9A Gene
SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9) is a Protein Coding gene. Diseases associated with SCN9A include Paroxysmal Extreme Pain Disorder and Indifference To Pain, Congenital, Autosomal Recessive. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include ion channel activity and sodium ion binding. An important paralog of this gene is SCN2A.
UniProtKB/Swiss-Prot Summary for SCN9A Gene
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.