Aliases for SCN3A Gene
- Sodium Voltage-Gated Channel Alpha Subunit 3 2 3 5
- Sodium Channel, Voltage-Gated, Type III, Alpha Polypeptide 2 3
- Sodium Channel, Voltage Gated, Type III Alpha Subunit 2 3
- Voltage-Gated Sodium Channel Subunit Alpha Nav1.3 3 4
- Sodium Channel Protein Brain III Subunit Alpha 3 4
- Sodium Channel Protein Type III Subunit Alpha 3 4
- Sodium Channel Protein Type 3 Subunit Alpha 3 4
External Ids for SCN3A Gene
Previous GeneCards Identifiers for SCN3A Gene
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SCN3A Gene
SCN3A (Sodium Voltage-Gated Channel Alpha Subunit 3) is a Protein Coding gene. Diseases associated with SCN3A include Epilepsy, Familial Focal, With Variable Foci 4 and Epileptic Encephalopathy, Early Infantile, 62. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Interaction between L1 and Ankyrins. Gene Ontology (GO) annotations related to this gene include ion channel activity and voltage-gated sodium channel activity. An important paralog of this gene is SCN2A.
UniProtKB/Swiss-Prot Summary for SCN3A Gene
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:24157691, PubMed:28235671, PubMed:29466837). May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity).
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.