Aliases for SCN2B Gene
- Sodium Voltage-Gated Channel Beta Subunit 2 2 3 5
- Sodium Channel, Voltage-Gated, Type II, Beta Polypeptide 2 3
- Sodium Channel, Voltage Gated, Type II Beta Subunit 2 3
- Sodium Channel Subunit Beta-2 3 4
- Neuronal Voltage-Gated Sodium Channel Beta 2 Subunit 3
- Sodium Channel, Voltage-Gated, Type II, Beta Subunit 2
- Sodium Channel, Voltage-Gated, Type II, Beta 2
- ATFB14 3
External Ids for SCN2B Gene
Previous GeneCards Identifiers for SCN2B Gene
The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]
GeneCards Summary for SCN2B Gene
SCN2B (Sodium Voltage-Gated Channel Beta Subunit 2) is a Protein Coding gene. Diseases associated with SCN2B include Atrial Fibrillation, Familial, 14 and Familial Atrial Fibrillation. Among its related pathways are Activation of cAMP-Dependent PKA and Developmental Biology. Gene Ontology (GO) annotations related to this gene include sodium channel regulator activity and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. An important paralog of this gene is JAML.
UniProtKB/Swiss-Prot Summary for SCN2B Gene
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.