SCN2B Gene (Protein Coding)

Sodium Voltage-Gated Channel Beta Subunit 2

GC11M118163
GIFtS:
44
The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015] See more...

Aliases for SCN2B Gene

Aliases for SCN2B Gene

  • Sodium Voltage-Gated Channel Beta Subunit 2 2 3 5
  • Sodium Channel, Voltage-Gated, Type II, Beta Polypeptide 2 3
  • Sodium Channel, Voltage Gated, Type II Beta Subunit 2 3
  • Sodium Channel Subunit Beta-2 3 4
  • Sodium Channel, Voltage-Gated, Type II, Beta Subunit 2
  • Neuronal Voltage-Gated Sodium Channel Beta 2 Subunit 3
  • Sodium Channel, Voltage-Gated, Type II, Beta 2
  • ATFB14 3
  • SCN2B 5

External Ids for SCN2B Gene

Previous GeneCards Identifiers for SCN2B Gene

  • GC11M120392
  • GC11M119545
  • GC11M118070
  • GC11M117573
  • GC11M117542
  • GC11M118033
  • GC11M113967

Summaries for SCN2B Gene

Entrez Gene Summary for SCN2B Gene

  • The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]

GeneCards Summary for SCN2B Gene

SCN2B (Sodium Voltage-Gated Channel Beta Subunit 2) is a Protein Coding gene. Diseases associated with SCN2B include Atrial Fibrillation, Familial, 14 and Brugada Syndrome. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include sodium channel regulator activity and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. An important paralog of this gene is SCN4B.

UniProtKB/Swiss-Prot Summary for SCN2B Gene

  • Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).

Tocris Summary for SCN2B Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.

Gene Wiki entry for SCN2B Gene

Additional gene information for SCN2B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCN2B Gene

Genomics for SCN2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SCN2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCN2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCN2B

Top Transcription factor binding sites by QIAGEN in the SCN2B gene promoter:
  • AML1a
  • c-Myb
  • HEN1
  • Pax-2
  • Pax-2a
  • S8

Genomic Locations for SCN2B Gene

Latest Assembly
chr11:118,162,806-118,176,639
(GRCh38/hg38)
Size:
13,834 bases
Orientation:
Minus strand

Previous Assembly
chr11:118,033,521-118,047,354
(GRCh37/hg19 by Entrez Gene)
Size:
13,834 bases
Orientation:
Minus strand

chr11:118,032,666-118,047,388
(GRCh37/hg19 by Ensembl)
Size:
14,723 bases
Orientation:
Minus strand

Genomic View for SCN2B Gene

Genes around SCN2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCN2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCN2B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SCN2B Gene

Proteins for SCN2B Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for SCN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60939-SCN2B_HUMAN
    Recommended name:
    Sodium channel subunit beta-2
    Protein Accession:
    O60939
    Secondary Accessions:
    • O75302
    • Q9UNN3

    Protein attributes for SCN2B Gene

    Size:
    215 amino acids
    Molecular mass:
    24326 Da
    Quaternary structure:
    • The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit (SCN2A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B). SCN1B and SCN3B are non-covalently associated with SCN2A. SCN2B and SCN4B are disulfide-linked to SCN2A.

    Three dimensional structures from OCA and Proteopedia for SCN2B Gene

neXtProt entry for SCN2B Gene

Protein Expression for SCN2B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SCN2B Gene

  • Glycosylation at Asn42, Asn66, and Asn74
  • Modification sites at PhosphoSitePlus

Other Protein References for SCN2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCN2B Gene

Domains & Families for SCN2B Gene

Gene Families for SCN2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SCN2B Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
  • Immunoglobulin subtype

Suggested Antigen Peptide Sequences for SCN2B Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94526, Homo sapiens sodium channel, voltage-gated, type II, beta (SCN2B),mRNA (Q5U0K8_HUMAN)
  • Sodium channel subunit beta-2 (SCN2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60939

UniProtKB/Swiss-Prot:

SCN2B_HUMAN :
  • Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.
Family:
  • Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.
genes like me logo Genes that share domains with SCN2B: view

Function for SCN2B Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for SCN2B Gene

UniProtKB/Swiss-Prot Function:
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
GENATLAS Biochemistry:
sodium voltage-gated channel,type II,auxilliary subunit beta homolog to rat contactin,involved in the initiation and conduction of electrical impulses in nerves,highly similar to myelin protein zero may be involved in demyelinating diseases,CMT2B excluded

Phenotypes From GWAS Catalog for SCN2B Gene

Gene Ontology (GO) - Molecular Function for SCN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005248 voltage-gated sodium channel activity IEA --
GO:0005272 sodium channel activity IEA --
GO:0017080 sodium channel regulator activity IDA 19808477
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP 19808477
genes like me logo Genes that share ontologies with SCN2B: view
genes like me logo Genes that share phenotypes with SCN2B: view

Human Phenotype Ontology for SCN2B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SCN2B Gene

MGI Knock Outs for SCN2B:

Animal Models for research

miRNA for SCN2B Gene

miRTarBase miRNAs that target SCN2B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCN2B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SCN2B Gene

Localization for SCN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCN2B Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCN2B gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for SCN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001518 voltage-gated sodium channel complex IDA,TAS 9295116
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with SCN2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCN2B Gene

Pathways & Interactions for SCN2B Gene

PathCards logo

SuperPathways for SCN2B Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
PKA Signaling
.56
2 Neuropathic Pain-Signaling in Dorsal Horn Neurons
Aldosterone Signaling in Epithelial Cells
.47
Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
Cholera Infection
.40
3 Developmental Biology
Axon guidance
.51
Developmental Biology
.51
4 Cardiac conduction
Cardiac conduction
.70
Muscle contraction
.70
5 Neuroscience
Neuroscience
-
genes like me logo Genes that share pathways with SCN2B: view

Pathways by source for SCN2B Gene

1 PharmGKB pathway for SCN2B Gene
7 Qiagen pathways for SCN2B Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • cAMP Pathway
  • Cholera Infection
  • GHRH Signaling
1 Cell Signaling Technology pathway for SCN2B Gene

Gene Ontology (GO) - Biological Process for SCN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0007268 chemical synaptic transmission TAS 9295116
GO:0007399 nervous system development IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SCN2B: view

No data available for SIGNOR curated interactions for SCN2B Gene

Drugs & Compounds for SCN2B Gene

Products:

  1. Drug products for research

(10) Drugs for SCN2B Gene - From: DrugBank, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor, blocker Antiepileptic with anticonvulsant and mechanistic effect 78
Brivaracetam Approved, Investigational Pharma Target, inhibitor 42
Cocaine Approved, Illicit Pharma Target, inhibitor 616
Dichlorobenzyl alcohol Approved Pharma Target, antagonist 0
Oxcarbazepine Approved Pharma Target, inhibitor BTX inhibitor 64

(2) Additional Compounds for SCN2B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
  • Sodium(1+)
 7440-23-5
Amiloride hydrochloride
2016-88-8

(3) Tocris Compounds for SCN2B Gene

Compound Action Cas Number
Amiloride hydrochloride Na+ channel blocker; also I2 imidazoline ligand 2016-88-8
Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant 298-46-4
Vinpocetine Na+ channel blocker 42971-09-5
genes like me logo Genes that share compounds with SCN2B: view

Transcripts for SCN2B Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for SCN2B Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCN2B

Alternative Splicing Database (ASD) splice patterns (SP) for SCN2B Gene

No ASD Table

Relevant External Links for SCN2B Gene

GeneLoc Exon Structure for
SCN2B

Expression for SCN2B Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCN2B Gene

mRNA expression in normal human tissues for SCN2B Gene
mRNA expression by GTEx for SCN2B GenemRNA expression by BioGPS for SCN2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCN2B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6), Brain - Cortex (x5.6), Brain - Cerebellar Hemisphere (x5.5), Brain - Cerebellum (x5.3), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.7).

Protein differential expression in normal tissues from HIPED for SCN2B Gene

This gene is overexpressed in Frontal cortex (60.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCN2B Gene



Protein tissue co-expression partners for SCN2B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCN2B

SOURCE GeneReport for Unigene cluster for SCN2B Gene:

Hs.129783

mRNA Expression by UniProt/SwissProt for SCN2B Gene:

O60939-SCN2B_HUMAN
Tissue specificity: Brain specific.

Evidence on tissue expression from TISSUES for SCN2B Gene

  • Nervous system(4.7)
  • Heart(4.4)
  • Muscle(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SCN2B Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • nervous
Regions:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • heart
  • heart valve
General:
  • blood
  • blood vessel
  • coagulation system
genes like me logo Genes that share expression patterns with SCN2B: view

Primer products for research

Orthologs for SCN2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCN2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SCN2B 29 30
  • 99.38 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SCN2B 29 30
  • 92.4 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SCN2B 29 30
  • 91.16 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Scn2b 29
  • 88.53 (n)
Mouse
(Mus musculus)
 Mammalia Scn2b 29 16 30
  • 87.75 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SCN2B 30
  • 82 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SCN2B 29 30
  • 77.05 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SCN2B 30
  • 66 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia scn2b 29
  • 65.7 (n)
Zebrafish
(Danio rerio)
 Actinopterygii scn2b 29 30
  • 60.33 (n)
 OneToOne
Species where no ortholog for SCN2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SCN2B Gene

ENSEMBL:
Gene Tree for SCN2B (if available)
TreeFam:
Gene Tree for SCN2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCN2B: view image
Alliance of Genome Resources:
Additional Orthologs for SCN2B

Paralogs for SCN2B Gene

Paralogs for SCN2B Gene

(1) SIMAP similar genes for SCN2B Gene using alignment to 2 proteins:

  • SCN2B_HUMAN
  • Q5U0K8_HUMAN
genes like me logo Genes that share paralogs with SCN2B: view

Variants for SCN2B Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCN2B Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
1006173 Uncertain Significance: Atrial fibrillation, familial, 14 118,176,427(-) T/C
NM_004588.5(SCN2B):c.5A>G (p.His2Arg) 		MISSENSE
1022738 Uncertain Significance: Atrial fibrillation, familial, 14 118,168,585(-) C/G
NM_004588.5(SCN2B):c.237G>C (p.Met79Ile) 		MISSENSE
1023340 Uncertain Significance: Atrial fibrillation, familial, 14 118,168,121(-) C/T
NM_004588.5(SCN2B):c.412G>A (p.Gly138Ser) 		MISSENSE
839407 Uncertain Significance: Atrial fibrillation, familial, 14 118,166,972(-) T/C
NM_004588.5(SCN2B):c.563A>G (p.Glu188Gly) 		MISSENSE
935689 Uncertain Significance: Atrial fibrillation, familial, 14 118,168,252(-) C/T
NM_004588.5(SCN2B):c.281G>A (p.Arg94Gln) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SCN2B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SCN2B Gene

Variant ID Type Subtype PubMed ID
nsv519116 CNV loss 19592680

Variation tolerance for SCN2B Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCN2B Gene

Human Gene Mutation Database (HGMD)
SCN2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCN2B
Leiden Open Variation Database (LOVD)
SCN2B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCN2B Gene

Disorders for SCN2B Gene

MalaCards: The human disease database

(16) MalaCards diseases for SCN2B Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search SCN2B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SCN2B_HUMAN
  • Atrial fibrillation, familial, 14 (ATFB14) [MIM:615378]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:19808477}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Note=Genetic variations in SCN2B may be involved in Brugada syndrome (PubMed:23559163). This tachyarrhythmia is characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO:0000269 PubMed:23559163}.

Additional Disease Information for SCN2B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SCN2B: view

No data available for Genatlas for SCN2B Gene

Publications for SCN2B Gene

  1. Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation. (PMID: 19808477) Watanabe H … Roden DM (Circulation. Arrhythmia and electrophysiology 2009) 3 4 40 72
  2. A missense mutation in the sodium channel β2 subunit reveals SCN2B as a new candidate gene for Brugada syndrome. (PMID: 23559163) Riuró H … Brugada R (Human mutation 2013) 3 4 72
  3. Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins. (PMID: 30765606) Shen H … Yan N (Science (New York, N.Y.) 2019) 3 4
  4. Binary architecture of the Nav1.2-β2 signaling complex. (PMID: 26894959) Das S … Van Petegem F (eLife 2016) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40

ExternalLinks

View latest publications for SCN2B gene in Mastermind

Products for SCN2B Gene

Sources for SCN2B Gene