Aliases for SCN11A Gene
- Sodium Voltage-Gated Channel Alpha Subunit 11 2 3 5
- Sodium Channel, Voltage-Gated, Type XI, Alpha Polypeptide 2 3
- Sodium Channel, Voltage-Gated, Type XI, Alpha Subunit 2 3
- Voltage-Gated Sodium Channel Subunit Alpha Nav1.9 3 4
- Sodium Channel Protein Type 11 Subunit Alpha 3 4
- Sodium Channel Protein Type XI Subunit Alpha 3 4
- Peripheral Nerve Sodium Channel 5 3 4
- Sensory Neuron Sodium Channel 2 3 4
- SCN12A 3 4
- SNS-2 2 3
- NaN 2 3
External Ids for SCN11A Gene
Previous HGNC Symbols for SCN11A Gene
Previous GeneCards Identifiers for SCN11A Gene
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
GeneCards Summary for SCN11A Gene
SCN11A (Sodium Voltage-Gated Channel Alpha Subunit 11) is a Protein Coding gene. Diseases associated with SCN11A include Episodic Pain Syndrome, Familial, 3 and Neuropathy, Hereditary Sensory And Autonomic, Type Vii. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include ion channel activity and voltage-gated sodium channel activity. An important paralog of this gene is SCN5A.
UniProtKB/Swiss-Prot Summary for SCN11A Gene
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.