Aliases for SCMH1 Gene

Aliases for SCMH1 Gene

  • Scm Polycomb Group Protein Homolog 1 2 3 5
  • Sex Comb On Midleg Homolog 1 3 4
  • Polycomb Protein SCMH1 3 4
  • Sex Comb On Midleg Homolog 1 (Drosophila) 2
  • Scml3 3

External Ids for SCMH1 Gene

Previous GeneCards Identifiers for SCMH1 Gene

  • GC01M041527
  • GC01M040496
  • GC01M040956
  • GC01M040906
  • GC01M041161
  • GC01M041265
  • GC01M039609

Summaries for SCMH1 Gene

GeneCards Summary for SCMH1 Gene

SCMH1 (Scm Polycomb Group Protein Homolog 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and SUMOylation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is SCML2.

UniProtKB/Swiss-Prot Summary for SCMH1 Gene

  • Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.

Gene Wiki entry for SCMH1 Gene

Additional gene information for SCMH1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCMH1 Gene

Genomics for SCMH1 Gene

GeneHancer (GH) Regulatory Elements for SCMH1 Gene

Promoters and enhancers for SCMH1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCMH1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCMH1 gene promoter:
  • aMEF-2
  • Bach1
  • c-Rel
  • CUTL1
  • MEF-2A
  • MRF-2
  • POU2F1
  • POU2F1a
  • POU3F1
  • S8

Genomic Locations for SCMH1 Gene

Genomic Locations for SCMH1 Gene
214,961 bases
Minus strand
214,956 bases
Minus strand

Genomic View for SCMH1 Gene

Genes around SCMH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCMH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCMH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCMH1 Gene

Proteins for SCMH1 Gene

  • Protein details for SCMH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Polycomb protein SCMH1
    Protein Accession:
    Secondary Accessions:
    • B4DRQ8
    • Q5VT76
    • Q6IAJ4
    • Q8WU48
    • Q9UKM5
    • Q9UKM6

    Protein attributes for SCMH1 Gene

    660 amino acids
    Molecular mass:
    73354 Da
    Quaternary structure:
    • Interacts with the SAM domain of PHC1 via its SAM domain in vitro (By similarity). Associates with a PRC1-like complex.

    Three dimensional structures from OCA and Proteopedia for SCMH1 Gene

    Alternative splice isoforms for SCMH1 Gene

neXtProt entry for SCMH1 Gene

Post-translational modifications for SCMH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCMH1 Gene

Domains & Families for SCMH1 Gene

Gene Families for SCMH1 Gene

Protein Domains for SCMH1 Gene

Suggested Antigen Peptide Sequences for SCMH1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57178, highly similar to Polycomb protein SCMH1 (B4DRQ8_HUMAN)
  • Sex comb on midleg homolog 1 (SCMH1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SCM family.
  • Belongs to the SCM family.
genes like me logo Genes that share domains with SCMH1: view

Function for SCMH1 Gene

Molecular function for SCMH1 Gene

UniProtKB/Swiss-Prot Function:
Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.
GENATLAS Biochemistry:
Drosophila sex comb on midley homolog,widely expressed,with isoforms

Phenotypes From GWAS Catalog for SCMH1 Gene

Gene Ontology (GO) - Molecular Function for SCMH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCMH1: view
genes like me logo Genes that share phenotypes with SCMH1: view

Animal Models for SCMH1 Gene

MGI Knock Outs for SCMH1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCMH1 Gene

Localization for SCMH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCMH1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCMH1 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCMH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0010369 chromocenter IEA --
genes like me logo Genes that share ontologies with SCMH1: view

Pathways & Interactions for SCMH1 Gene

genes like me logo Genes that share pathways with SCMH1: view

Gene Ontology (GO) - Biological Process for SCMH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with SCMH1: view

No data available for SIGNOR curated interactions for SCMH1 Gene

Drugs & Compounds for SCMH1 Gene

(1) Drugs for SCMH1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mercaptoethanol Experimental Pharma Target 0
genes like me logo Genes that share compounds with SCMH1: view

Transcripts for SCMH1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCMH1 Gene

No ASD Table

Relevant External Links for SCMH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCMH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCMH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCMH1 Gene

Protein tissue co-expression partners for SCMH1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCMH1 Gene:


SOURCE GeneReport for Unigene cluster for SCMH1 Gene:


mRNA Expression by UniProt/SwissProt for SCMH1 Gene:

Tissue specificity: Strongly expressed in heart, muscle and pancreas. Weakly expressed in brain, placenta, lung, liver and kidney.

Evidence on tissue expression from TISSUES for SCMH1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with SCMH1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCMH1 Gene

Orthologs for SCMH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCMH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCMH1 33 32
  • 99.85 (n)
(Canis familiaris)
Mammalia SCMH1 33 32
  • 94.2 (n)
(Bos Taurus)
Mammalia SCMH1 33 32
  • 92.94 (n)
(Rattus norvegicus)
Mammalia Scmh1 32
  • 91.35 (n)
(Mus musculus)
Mammalia Scmh1 17 33 32
  • 91.3 (n)
(Monodelphis domestica)
Mammalia SCMH1 33
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SCMH1 33
  • 70 (a)
(Gallus gallus)
Aves SCMH1 33 32
  • 79.39 (n)
(Anolis carolinensis)
Reptilia SCMH1 33
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scmh1 32
  • 68.82 (n)
Str.17540 32
(Danio rerio)
Actinopterygii scmh1 33
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Scm 33 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6357 33
  • 30 (a)
Species where no ortholog for SCMH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCMH1 Gene

Gene Tree for SCMH1 (if available)
Gene Tree for SCMH1 (if available)
Evolutionary constrained regions (ECRs) for SCMH1: view image

Paralogs for SCMH1 Gene

(5) SIMAP similar genes for SCMH1 Gene using alignment to 2 proteins:

  • J3KPV8_HUMAN Pseudogenes for SCMH1 Gene

genes like me logo Genes that share paralogs with SCMH1: view

Variants for SCMH1 Gene

Sequence variations from dbSNP and Humsavar for SCMH1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000005548 -- 41,129,368(-) C/T intron_variant
rs1000017210 -- 41,123,215(-) C/G intron_variant
rs1000037567 -- 41,085,136(-) AAATAAAATAAAATAAAA/AAATAAAATAAAA intron_variant
rs1000044786 -- 41,130,808(-) G/T intron_variant
rs1000048207 -- 41,039,760(-) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SCMH1 Gene

Variant ID Type Subtype PubMed ID
esv24588 CNV loss 19812545
esv2571087 CNV deletion 19546169
esv2669275 CNV deletion 23128226
esv3304788 CNV mobile element insertion 20981092
esv3332583 CNV insertion 20981092
esv3427723 CNV insertion 20981092
esv3585819 CNV loss 21293372
esv3585820 CNV loss 21293372
nsv1013869 CNV gain 25217958
nsv1129129 CNV insertion 24896259
nsv1136081 CNV deletion 24896259
nsv1145338 CNV deletion 24896259
nsv519146 CNV gain 19592680
nsv546103 CNV loss 21841781
nsv945901 CNV duplication 23825009
nsv950698 CNV duplication 24416366

Variation tolerance for SCMH1 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCMH1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCMH1 Gene

Disorders for SCMH1 Gene

Additional Disease Information for SCMH1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SCMH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCMH1 Gene

Publications for SCMH1 Gene

  1. The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34. (PMID: 10524249) Berger J … Randazzo F (Gene 1999) 2 3 4 56
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 43 56
  3. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PMID: 19266077) Sovio U … Jarvelin MR (PLoS genetics 2009) 3 43 56
  4. Genome-wide association analysis identifies 20 loci that influence adult height. (PMID: 18391952) Weedon MN … Frayling TM (Nature genetics 2008) 3 43 56
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56

Products for SCMH1 Gene

Sources for SCMH1 Gene