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The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]
SCGN (Secretagogin, EF-Hand Calcium Binding Protein) is a Protein Coding gene. Diseases associated with SCGN include Insulinoma and Neuroendocrine Tumor. Among its related pathways are Neuroscience and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CALB2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IBA,NAS | 10811645 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | NAS | 10811645 |
GO:0005829 | cytosol | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ca, cAMP and Lipid Signaling | ||
2 | Neuroscience |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008150 | biological_process | ND | -- |
GO:0051480 | regulation of cytosolic calcium ion concentration | IBA | 21873635 |
GO:0099509 | regulation of presynaptic cytosolic calcium ion concentration | IBA | 21873635 |
GO:1900271 | regulation of long-term synaptic potentiation | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SCGN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SCGN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SCGN 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Scgn 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Scgn 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SCGN 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SCGN 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SCGN 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SCGN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | scgn 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | scgn 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4518 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012179 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Cbp53E 30 31 32 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.13086 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3608389 | CNV | gain | 21293372 |
Disorder | Aliases | PubMed IDs |
---|---|---|
insulinoma |
|
|
neuroendocrine tumor |
|