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Aliases for SCGB3A2 Gene

Aliases for SCGB3A2 Gene

  • Secretoglobin Family 3A Member 2 2 3 3 5
  • Uteroglobin-Related Protein 1 2 3 4
  • Pneumo Secretory Protein 1 2 3 4
  • PnSP-1 3 4
  • PNSP1 3 4
  • UGRP1 3 4
  • Uteroglobin Related Protein 1 2
  • LU103 3

External Ids for SCGB3A2 Gene

Previous GeneCards Identifiers for SCGB3A2 Gene

  • GC05P147290
  • GC05P147840
  • GC05P147286
  • GC05P147238
  • GC05P142405
  • GC05P147250

Summaries for SCGB3A2 Gene

Entrez Gene Summary for SCGB3A2 Gene

  • The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010]

GeneCards Summary for SCGB3A2 Gene

SCGB3A2 (Secretoglobin Family 3A Member 2) is a Protein Coding gene. Diseases associated with SCGB3A2 include Asthma. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport. An important paralog of this gene is SCGB3A1.

UniProtKB/Swiss-Prot for SCGB3A2 Gene

  • Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity).

Gene Wiki entry for SCGB3A2 Gene

Additional gene information for SCGB3A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB3A2 Gene

Genomics for SCGB3A2 Gene

GeneHancer (GH) Regulatory Elements for SCGB3A2 Gene

Promoters and enhancers for SCGB3A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J147868 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 660.9 -0.9 -925 1.7 SP1 POLR2A POU5F1 SIN3A SCGB3A2 GC05P147856
GH05J147878 Promoter 0.5 EPDnew 650.4 +8.0 8010 0.1 SCGB3A2 ENSG00000248362
GH05J147873 Enhancer 0.4 dbSUPER 660.9 +1.7 1657 0.4 POLR2A EZH2 SCGB3A2 ENSG00000251320 ENSG00000248362 GC05P147856
GH05J147905 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 8.7 +35.7 35680 1.7 SMARCC1 JUN HLF CEBPB EP300 ATF2 ZNF335 GATA3 JUND CEBPA C5orf46 ENSG00000251320 SCGB3A2
GH05J147872 Enhancer 0.9 Ensembl ENCODE dbSUPER 9.9 +3.7 3739 3.2 SP1 NANOG POLR2A POU5F1 SIN3A EZH2 SCGB3A2 ENSG00000251320 ENSG00000248362 GC05P147856
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCGB3A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCGB3A2 gene promoter:
  • Pax-3
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • Nkx2-2

Genomic Locations for SCGB3A2 Gene

Genomic Locations for SCGB3A2 Gene
chr5:147,870,682-147,882,193
(GRCh38/hg38)
Size:
11,512 bases
Orientation:
Plus strand
chr5:147,250,245-147,261,756
(GRCh37/hg19)
Size:
11,512 bases
Orientation:
Plus strand

Genomic View for SCGB3A2 Gene

Genes around SCGB3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB3A2 Gene

Proteins for SCGB3A2 Gene

  • Protein details for SCGB3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PL1-SG3A2_HUMAN
    Recommended name:
    Secretoglobin family 3A member 2
    Protein Accession:
    Q96PL1

    Protein attributes for SCGB3A2 Gene

    Size:
    93 amino acids
    Molecular mass:
    10161 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (PubMed:24213919). Monomer (PubMed:24213919). Interacts with APOA1 (PubMed:12847263).

neXtProt entry for SCGB3A2 Gene

Post-translational modifications for SCGB3A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB3A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SCGB3A2 (UGRP1/SCGB3A2)
  • Abcam antibodies for SCGB3A2
  • Santa Cruz Biotechnology (SCBT) Antibodies for SCGB3A2

No data available for DME Specific Peptides for SCGB3A2 Gene

Domains & Families for SCGB3A2 Gene

Gene Families for SCGB3A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SCGB3A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB3A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PL1

UniProtKB/Swiss-Prot:

SG3A2_HUMAN :
  • Belongs to the secretoglobin family. UGRP subfamily.
Family:
  • Belongs to the secretoglobin family. UGRP subfamily.
genes like me logo Genes that share domains with SCGB3A2: view

Function for SCGB3A2 Gene

Molecular function for SCGB3A2 Gene

UniProtKB/Swiss-Prot Function:
Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity).
genes like me logo Genes that share phenotypes with SCGB3A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCGB3A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB3A2 Gene

Localization for SCGB3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB3A2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB3A2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0071682 endocytic vesicle lumen TAS --
genes like me logo Genes that share ontologies with SCGB3A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB3A2 Gene

Pathways & Interactions for SCGB3A2 Gene

genes like me logo Genes that share pathways with SCGB3A2: view

Pathways by source for SCGB3A2 Gene

Interacting Proteins for SCGB3A2 Gene

Gene Ontology (GO) - Biological Process for SCGB3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with SCGB3A2: view

No data available for SIGNOR curated interactions for SCGB3A2 Gene

Drugs & Compounds for SCGB3A2 Gene

No Compound Related Data Available

Transcripts for SCGB3A2 Gene

mRNA/cDNA for SCGB3A2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(69) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB3A2 Gene

Secretoglobin, family 3A, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB3A2 Gene

No ASD Table

Relevant External Links for SCGB3A2 Gene

GeneLoc Exon Structure for
SCGB3A2
ECgene alternative splicing isoforms for
SCGB3A2

Expression for SCGB3A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCGB3A2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB3A2 Gene

This gene is overexpressed in Lung (x50.2).

Protein differential expression in normal tissues from HIPED for SCGB3A2 Gene

This gene is overexpressed in Fetal gut (35.0) and Pancreatic juice (30.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB3A2 Gene



Protein tissue co-expression partners for SCGB3A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCGB3A2 Gene:

SCGB3A2

SOURCE GeneReport for Unigene cluster for SCGB3A2 Gene:

Hs.483765

mRNA Expression by UniProt/SwissProt for SCGB3A2 Gene:

Q96PL1-SG3A2_HUMAN
Tissue specificity: Highly expressed in lung and trachea (PubMed:12406855, PubMed:12175512, PubMed:12847263). Detected throughout the airway epithelium in lung, with slightly higher expression in large airways (PubMed:12406855). Found in lung submucosal gland acinus where it localizes to serous-like cells (PubMed:12406855). Probably expressed in club/Clara cells of the bronchioles (PubMed:12847263). Not detected in other tissues tested (PubMed:12847263).

Evidence on tissue expression from TISSUES for SCGB3A2 Gene

  • Lung(4.8)
genes like me logo Genes that share expression patterns with SCGB3A2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB3A2 Gene

Orthologs for SCGB3A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB3A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB3A2 34 33
  • 99.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SCGB3A2 34 33
  • 84.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB3A2 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scgb3a2 33
  • 82.08 (n)
mouse
(Mus musculus)
Mammalia Scgb3a2 16 34 33
  • 79.76 (n)
oppossum
(Monodelphis domestica)
Mammalia SCGB3A2 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
Species where no ortholog for SCGB3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB3A2 Gene

ENSEMBL:
Gene Tree for SCGB3A2 (if available)
TreeFam:
Gene Tree for SCGB3A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCGB3A2: view image

Paralogs for SCGB3A2 Gene

Paralogs for SCGB3A2 Gene

(2) SIMAP similar genes for SCGB3A2 Gene using alignment to 2 proteins:

  • SG3A2_HUMAN
  • D6RBX5_HUMAN
genes like me logo Genes that share paralogs with SCGB3A2: view

Variants for SCGB3A2 Gene

Sequence variations from dbSNP and Humsavar for SCGB3A2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
VAR_036185 A breast cancer sample p.Lys33Asn
rs1001384711 -- 147,880,779(+) C/T intron_variant
rs1001958380 -- 147,879,125(+) C/A intron_variant
rs1002072924 -- 147,879,402(+) C/G intron_variant
rs1002458498 -- 147,881,409(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SCGB3A2 Gene

Variant ID Type Subtype PubMed ID
esv3570488 CNV loss 25503493
nsv1021356 CNV gain 25217958
nsv1028477 CNV loss 25217958

Variation tolerance for SCGB3A2 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCGB3A2 Gene

Human Gene Mutation Database (HGMD)
SCGB3A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB3A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB3A2 Gene

Disorders for SCGB3A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCGB3A2 Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SCGB3A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SCGB3A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB3A2 Gene

Publications for SCGB3A2 Gene

  1. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. (PMID: 11682631) Niimi T … Kimura S (Molecular endocrinology (Baltimore, Md.) 2001) 2 3 4 22 58
  2. Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma. (PMID: 18089940) Inoue K … Munakata M (Allergology international : official journal of the Japanese Society of Allergology 2008) 3 22 44 58
  3. Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population. (PMID: 15591807) Batra J … Ghosh B (International archives of allergy and immunology 2005) 3 22 44 58
  4. A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. (PMID: 11813133) Niimi T … Kimura S (American journal of human genetics 2002) 3 22 44 58
  5. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3 58

Products for SCGB3A2 Gene

Sources for SCGB3A2 Gene

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